Clinical status and mortality in older adults with type 1 diabetes: Results from a public health system
•Understanding risk factors for cardiovascular disease among older adult patients with diabetes becomes increasingly important.•Information concerning cardiovascular risk factors among older adult patients with type 1 diabetes mellitus is scarce.•We evaluate clinical status and mortality of long-sta...
Gespeichert in:
| Veröffentlicht in: | Diabetes research and clinical practice 2022-03, Vol.185, p.109221-109221, Article 109221 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 109221 |
|---|---|
| container_issue | |
| container_start_page | 109221 |
| container_title | Diabetes research and clinical practice |
| container_volume | 185 |
| creator | Moreno-Fernandez, Jesus Sastre, Julia Pinés, Pedro del Val, Florentino Calderon-Vicente, Dulce Quiroga, Ivan Herranz, Sandra Lopez Gallardo, Gema Gonzalez, Javier Muñoz-Rodriguez, Jose-Ramón |
| description | •Understanding risk factors for cardiovascular disease among older adult patients with diabetes becomes increasingly important.•Information concerning cardiovascular risk factors among older adult patients with type 1 diabetes mellitus is scarce.•We evaluate clinical status and mortality of long-standing diabetes patients along a 10-yr period.•Long-standing type 1 diabetes patients improved glycemic control although a worsening of cardiovascular risk factors was detected.•In fact, observed mortality was higher in this group of patients.
To evaluate clinical status and mortality in older adults with long-standing type 1 diabetes mellitus (T1D).
Cross-sectional analysis of all patients with T1D for 50 years or more from a cohort followed since 2010 at Castilla-La Mancha Public Health Service (Spain). Primary outcome was HbA1c change during the follow-up (2010–2020 period). Secondary outcomes included evaluation of insulin and continuous glucose monitoring (CGM) use, cardiovascular risk factors (CVRF), diabetes chronic complications and mortality.
A total of fifty-five T1D patients were analysed. Mean age was 69.5 ± 8.3 yrs. and T1D duration of 54.7 ± 4.7 yrs. We detected a HbA1c reduction of −0.5% (-6 mmol/mol) [95% CI −0.1, −0.9 (-2, −10); P = 0.016]. CGM was used by 26% of the patients. More patients suffered from hypertension and obesity in 2020 (66% vs. 78%, P = 0.016; and 26% vs. 31%, P = 0.016; respectively). An increase of diabetic polyneuropathy was detected (45% vs. 67%, P = 0.008). Rate of mortality was higher among patients with long-standing T1D (26% vs. 3.5%, P |
| doi_str_mv | 10.1016/j.diabres.2022.109221 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2624659331</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S016882272200033X</els_id><sourcerecordid>2624659331</sourcerecordid><originalsourceid>FETCH-LOGICAL-c313t-d0e1b1456542f31ba44f52933afddb0479777be96403367507dc1f631b7567d03</originalsourceid><addsrcrecordid>eNqFkM1uGyEUhVHUKHF-HiEVy27s8jOAnU1UWWlTKVKlqF0jBu4kWMyMy2Ua-e2DY7fbrkDw3XPgI-SGswVnXH_eLEJ0bQZcCCZEPVsJwU_IjC-NmC-FMB_IrHLL9_05uUDcMMa0bNQZOZeqZjRKzcjzOsUhepcoFlcmpG4ItB9zcSmWHY0DHVOATF2YUkH6GssLLbstUE73_VAAb-kT4Pttl8eeOrqd2hQ9fQGXKo07LNBfkdPOJYTr43pJfn29_7l-mD_--PZ9_eVx7iWXZR4Y8La-TKtGdJK3rmk6JVZSui6EljVmZYxpYaUbJqU2ipngeacraZQ2gclL8umQu83j7wmw2D6ih5TcAOOEVmjRaFUDeUXVAfV5RMzQ2W2Ovcs7y5ndO7Ybe3Rs947twXGd-3ismNoewr-pv1IrcHcAoH70T4Rs0UcYPISYwRcbxvifijc6ro8m</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2624659331</pqid></control><display><type>article</type><title>Clinical status and mortality in older adults with type 1 diabetes: Results from a public health system</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Moreno-Fernandez, Jesus ; Sastre, Julia ; Pinés, Pedro ; del Val, Florentino ; Calderon-Vicente, Dulce ; Quiroga, Ivan ; Herranz, Sandra ; Lopez Gallardo, Gema ; Gonzalez, Javier ; Muñoz-Rodriguez, Jose-Ramón</creator><creatorcontrib>Moreno-Fernandez, Jesus ; Sastre, Julia ; Pinés, Pedro ; del Val, Florentino ; Calderon-Vicente, Dulce ; Quiroga, Ivan ; Herranz, Sandra ; Lopez Gallardo, Gema ; Gonzalez, Javier ; Muñoz-Rodriguez, Jose-Ramón</creatorcontrib><description>•Understanding risk factors for cardiovascular disease among older adult patients with diabetes becomes increasingly important.•Information concerning cardiovascular risk factors among older adult patients with type 1 diabetes mellitus is scarce.•We evaluate clinical status and mortality of long-standing diabetes patients along a 10-yr period.•Long-standing type 1 diabetes patients improved glycemic control although a worsening of cardiovascular risk factors was detected.•In fact, observed mortality was higher in this group of patients.
To evaluate clinical status and mortality in older adults with long-standing type 1 diabetes mellitus (T1D).
Cross-sectional analysis of all patients with T1D for 50 years or more from a cohort followed since 2010 at Castilla-La Mancha Public Health Service (Spain). Primary outcome was HbA1c change during the follow-up (2010–2020 period). Secondary outcomes included evaluation of insulin and continuous glucose monitoring (CGM) use, cardiovascular risk factors (CVRF), diabetes chronic complications and mortality.
A total of fifty-five T1D patients were analysed. Mean age was 69.5 ± 8.3 yrs. and T1D duration of 54.7 ± 4.7 yrs. We detected a HbA1c reduction of −0.5% (-6 mmol/mol) [95% CI −0.1, −0.9 (-2, −10); P = 0.016]. CGM was used by 26% of the patients. More patients suffered from hypertension and obesity in 2020 (66% vs. 78%, P = 0.016; and 26% vs. 31%, P = 0.016; respectively). An increase of diabetic polyneuropathy was detected (45% vs. 67%, P = 0.008). Rate of mortality was higher among patients with long-standing T1D (26% vs. 3.5%, P < 0.001), due to cardiovascular disease (57%).
Older adults with long-standing T1D patients improved glycemic control although a worsening of CVRF and higher mortality rateweredetected.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2022.109221</identifier><identifier>PMID: 35101455</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Aged ; Blood Glucose ; Blood Glucose Self-Monitoring ; Cross-Sectional Studies ; Diabetes Complications - complications ; Diabetes Mellitus, Type 1 - complications ; Glycated Hemoglobin A - analysis ; Humans ; Hypoglycemic Agents - adverse effects ; Insulin - therapeutic use ; Middle Aged ; Public Health</subject><ispartof>Diabetes research and clinical practice, 2022-03, Vol.185, p.109221-109221, Article 109221</ispartof><rights>2022 Elsevier B.V.</rights><rights>Copyright © 2022 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c313t-d0e1b1456542f31ba44f52933afddb0479777be96403367507dc1f631b7567d03</cites><orcidid>0000-0002-6045-2039 ; 0000-0002-9703-1094</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016882272200033X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35101455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreno-Fernandez, Jesus</creatorcontrib><creatorcontrib>Sastre, Julia</creatorcontrib><creatorcontrib>Pinés, Pedro</creatorcontrib><creatorcontrib>del Val, Florentino</creatorcontrib><creatorcontrib>Calderon-Vicente, Dulce</creatorcontrib><creatorcontrib>Quiroga, Ivan</creatorcontrib><creatorcontrib>Herranz, Sandra</creatorcontrib><creatorcontrib>Lopez Gallardo, Gema</creatorcontrib><creatorcontrib>Gonzalez, Javier</creatorcontrib><creatorcontrib>Muñoz-Rodriguez, Jose-Ramón</creatorcontrib><title>Clinical status and mortality in older adults with type 1 diabetes: Results from a public health system</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>•Understanding risk factors for cardiovascular disease among older adult patients with diabetes becomes increasingly important.•Information concerning cardiovascular risk factors among older adult patients with type 1 diabetes mellitus is scarce.•We evaluate clinical status and mortality of long-standing diabetes patients along a 10-yr period.•Long-standing type 1 diabetes patients improved glycemic control although a worsening of cardiovascular risk factors was detected.•In fact, observed mortality was higher in this group of patients.
To evaluate clinical status and mortality in older adults with long-standing type 1 diabetes mellitus (T1D).
Cross-sectional analysis of all patients with T1D for 50 years or more from a cohort followed since 2010 at Castilla-La Mancha Public Health Service (Spain). Primary outcome was HbA1c change during the follow-up (2010–2020 period). Secondary outcomes included evaluation of insulin and continuous glucose monitoring (CGM) use, cardiovascular risk factors (CVRF), diabetes chronic complications and mortality.
A total of fifty-five T1D patients were analysed. Mean age was 69.5 ± 8.3 yrs. and T1D duration of 54.7 ± 4.7 yrs. We detected a HbA1c reduction of −0.5% (-6 mmol/mol) [95% CI −0.1, −0.9 (-2, −10); P = 0.016]. CGM was used by 26% of the patients. More patients suffered from hypertension and obesity in 2020 (66% vs. 78%, P = 0.016; and 26% vs. 31%, P = 0.016; respectively). An increase of diabetic polyneuropathy was detected (45% vs. 67%, P = 0.008). Rate of mortality was higher among patients with long-standing T1D (26% vs. 3.5%, P < 0.001), due to cardiovascular disease (57%).
Older adults with long-standing T1D patients improved glycemic control although a worsening of CVRF and higher mortality rateweredetected.</description><subject>Aged</subject><subject>Blood Glucose</subject><subject>Blood Glucose Self-Monitoring</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Complications - complications</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Hypoglycemic Agents - adverse effects</subject><subject>Insulin - therapeutic use</subject><subject>Middle Aged</subject><subject>Public Health</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1uGyEUhVHUKHF-HiEVy27s8jOAnU1UWWlTKVKlqF0jBu4kWMyMy2Ua-e2DY7fbrkDw3XPgI-SGswVnXH_eLEJ0bQZcCCZEPVsJwU_IjC-NmC-FMB_IrHLL9_05uUDcMMa0bNQZOZeqZjRKzcjzOsUhepcoFlcmpG4ItB9zcSmWHY0DHVOATF2YUkH6GssLLbstUE73_VAAb-kT4Pttl8eeOrqd2hQ9fQGXKo07LNBfkdPOJYTr43pJfn29_7l-mD_--PZ9_eVx7iWXZR4Y8La-TKtGdJK3rmk6JVZSui6EljVmZYxpYaUbJqU2ipngeacraZQ2gclL8umQu83j7wmw2D6ih5TcAOOEVmjRaFUDeUXVAfV5RMzQ2W2Ovcs7y5ndO7Ybe3Rs947twXGd-3ismNoewr-pv1IrcHcAoH70T4Rs0UcYPISYwRcbxvifijc6ro8m</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Moreno-Fernandez, Jesus</creator><creator>Sastre, Julia</creator><creator>Pinés, Pedro</creator><creator>del Val, Florentino</creator><creator>Calderon-Vicente, Dulce</creator><creator>Quiroga, Ivan</creator><creator>Herranz, Sandra</creator><creator>Lopez Gallardo, Gema</creator><creator>Gonzalez, Javier</creator><creator>Muñoz-Rodriguez, Jose-Ramón</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6045-2039</orcidid><orcidid>https://orcid.org/0000-0002-9703-1094</orcidid></search><sort><creationdate>202203</creationdate><title>Clinical status and mortality in older adults with type 1 diabetes: Results from a public health system</title><author>Moreno-Fernandez, Jesus ; Sastre, Julia ; Pinés, Pedro ; del Val, Florentino ; Calderon-Vicente, Dulce ; Quiroga, Ivan ; Herranz, Sandra ; Lopez Gallardo, Gema ; Gonzalez, Javier ; Muñoz-Rodriguez, Jose-Ramón</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-d0e1b1456542f31ba44f52933afddb0479777be96403367507dc1f631b7567d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Blood Glucose</topic><topic>Blood Glucose Self-Monitoring</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Complications - complications</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Hypoglycemic Agents - adverse effects</topic><topic>Insulin - therapeutic use</topic><topic>Middle Aged</topic><topic>Public Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moreno-Fernandez, Jesus</creatorcontrib><creatorcontrib>Sastre, Julia</creatorcontrib><creatorcontrib>Pinés, Pedro</creatorcontrib><creatorcontrib>del Val, Florentino</creatorcontrib><creatorcontrib>Calderon-Vicente, Dulce</creatorcontrib><creatorcontrib>Quiroga, Ivan</creatorcontrib><creatorcontrib>Herranz, Sandra</creatorcontrib><creatorcontrib>Lopez Gallardo, Gema</creatorcontrib><creatorcontrib>Gonzalez, Javier</creatorcontrib><creatorcontrib>Muñoz-Rodriguez, Jose-Ramón</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreno-Fernandez, Jesus</au><au>Sastre, Julia</au><au>Pinés, Pedro</au><au>del Val, Florentino</au><au>Calderon-Vicente, Dulce</au><au>Quiroga, Ivan</au><au>Herranz, Sandra</au><au>Lopez Gallardo, Gema</au><au>Gonzalez, Javier</au><au>Muñoz-Rodriguez, Jose-Ramón</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical status and mortality in older adults with type 1 diabetes: Results from a public health system</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2022-03</date><risdate>2022</risdate><volume>185</volume><spage>109221</spage><epage>109221</epage><pages>109221-109221</pages><artnum>109221</artnum><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>•Understanding risk factors for cardiovascular disease among older adult patients with diabetes becomes increasingly important.•Information concerning cardiovascular risk factors among older adult patients with type 1 diabetes mellitus is scarce.•We evaluate clinical status and mortality of long-standing diabetes patients along a 10-yr period.•Long-standing type 1 diabetes patients improved glycemic control although a worsening of cardiovascular risk factors was detected.•In fact, observed mortality was higher in this group of patients.
To evaluate clinical status and mortality in older adults with long-standing type 1 diabetes mellitus (T1D).
Cross-sectional analysis of all patients with T1D for 50 years or more from a cohort followed since 2010 at Castilla-La Mancha Public Health Service (Spain). Primary outcome was HbA1c change during the follow-up (2010–2020 period). Secondary outcomes included evaluation of insulin and continuous glucose monitoring (CGM) use, cardiovascular risk factors (CVRF), diabetes chronic complications and mortality.
A total of fifty-five T1D patients were analysed. Mean age was 69.5 ± 8.3 yrs. and T1D duration of 54.7 ± 4.7 yrs. We detected a HbA1c reduction of −0.5% (-6 mmol/mol) [95% CI −0.1, −0.9 (-2, −10); P = 0.016]. CGM was used by 26% of the patients. More patients suffered from hypertension and obesity in 2020 (66% vs. 78%, P = 0.016; and 26% vs. 31%, P = 0.016; respectively). An increase of diabetic polyneuropathy was detected (45% vs. 67%, P = 0.008). Rate of mortality was higher among patients with long-standing T1D (26% vs. 3.5%, P < 0.001), due to cardiovascular disease (57%).
Older adults with long-standing T1D patients improved glycemic control although a worsening of CVRF and higher mortality rateweredetected.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>35101455</pmid><doi>10.1016/j.diabres.2022.109221</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6045-2039</orcidid><orcidid>https://orcid.org/0000-0002-9703-1094</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-8227 |
| ispartof | Diabetes research and clinical practice, 2022-03, Vol.185, p.109221-109221, Article 109221 |
| issn | 0168-8227 1872-8227 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2624659331 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Blood Glucose Blood Glucose Self-Monitoring Cross-Sectional Studies Diabetes Complications - complications Diabetes Mellitus, Type 1 - complications Glycated Hemoglobin A - analysis Humans Hypoglycemic Agents - adverse effects Insulin - therapeutic use Middle Aged Public Health |
| title | Clinical status and mortality in older adults with type 1 diabetes: Results from a public health system |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T23%3A14%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20status%20and%20mortality%20in%20older%20adults%20with%20type%201%20diabetes:%20Results%20from%20a%20public%20health%20system&rft.jtitle=Diabetes%20research%20and%20clinical%20practice&rft.au=Moreno-Fernandez,%20Jesus&rft.date=2022-03&rft.volume=185&rft.spage=109221&rft.epage=109221&rft.pages=109221-109221&rft.artnum=109221&rft.issn=0168-8227&rft.eissn=1872-8227&rft_id=info:doi/10.1016/j.diabres.2022.109221&rft_dat=%3Cproquest_cross%3E2624659331%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2624659331&rft_id=info:pmid/35101455&rft_els_id=S016882272200033X&rfr_iscdi=true |