The neuropeptide cycloprolylglycine produces antidepressant-like effect and enhances BDNF gene expression in the mice cortex

Background: Cycloprolylglycine (CPG) is an endogenous dipeptide with a wide range of psychotropic activity and putative therapeutic potential for depression. A small but growing body of data suggests that antidepressant-like effect of CPG is associated with neuroplastic changes in the brain or 5-HT...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2022-02, Vol.36 (2), p.214-222
Hauptverfasser:	Abdullina, Aliya A, Vasileva, Ekaterina V, Kulikova, Elizabeth A, Naumenko, Vladimir S, Plyusnina, Alexandra V, Gudasheva, Tatyana A, Kovalev, Georgy I, Seredenin, Sergei B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressants Antidepressive Agents - administration & dosage Antidepressive Agents - pharmacology Behavior, Animal - drug effects Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Catalepsy Coding Cognition Cortex (frontal) Cyclic AMP response element-binding protein Depression - drug therapy Disease Models, Animal Dose-Response Relationship, Drug Fluoxetine Fluoxetine - pharmacology Frontal Lobe - drug effects Gene expression Gene Expression Regulation - drug effects Locomotor activity Male Mental depression Mice Open-field behavior Peptides, Cyclic - administration & dosage Peptides, Cyclic - pharmacology Polymerase chain reaction Reverse transcription RNA, Messenger - metabolism Serotonin S1 receptors Serotonin S2 receptors
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