ENSMUST00000147869 regulates proliferation and fibrosis of mesangial cells in diabetic nephropathy by interacting with Hspa9

Our previous study showed that ENSMUST00000147869 was abnormally low expressed in the early stage of diabetic nephropathy (DN). ENSMUST00000147869 could inhibit the fibrosis and proliferation of mouse mesangial cells (MMCs), but the mechanism is still unclear. This study aims to explore the specific...

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Veröffentlicht in:	IUBMB life 2022-05, Vol.74 (5), p.419-432
Hauptverfasser:	Wang, Min, Chen, Xin, Zhang, Henglu, Li, Lanlan, Xu, Yang, Lu, Weiping, Lu, Yibing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell proliferation Cell Proliferation - genetics Diabetes Diabetes mellitus Diabetes Mellitus - pathology Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism diabetic nephropathy Female Fibrosis HMGB1 HMGB1 protein HMGB1 Protein - metabolism HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Hspa9 Humans Immunoprecipitation lncRNA Male Mass spectroscopy Mesangial cells Mesangial Cells - metabolism Mesangial Cells - pathology Mice Mitochondrial Proteins - metabolism Nephropathy proliferation and fibrosis Proteasomes Proteins RNA, Small Interfering - metabolism siRNA Therapeutic targets Ubiquitin Ubiquitination
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