Total Syntheses of Strasseriolide A and B, Antimalarial Macrolide Natural Products

We report the first total syntheses of strasseriolide A and B. Strasseriolide B shows potent activity against the wild-type malaria parasite Plasmodium falciparum and good activity against a chloroquine-resistant strain. A convergent strategy was envisioned with an aldehyde-acid fragment and a vinyl...

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Veröffentlicht in:	Organic letters 2022-02, Vol.24 (5), p.1190-1194
Hauptverfasser:	Salituro, Leah J., Pazienza, Jessica E., Rychnovsky, Scott D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Biological Products - chemical synthesis Biological Products - chemistry Biological Products - pharmacology Macrolides - chemical synthesis Macrolides - chemistry Macrolides - pharmacology Molecular Conformation Parasitic Sensitivity Tests Plasmodium falciparum - drug effects
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