Patient derived ex vivo tissue slice cultures demonstrate a profound DNA double-strand break repair defect in HPV-positive oropharyngeal head and neck cancer

•Human HPV+ OPSCC cultures show more DNA damage 24h post ex vivo irradiation than HPV-.•DNA damage levels in HPV+ OPSCC cultures are associated with patients` smoking status.•ATM inhibition enhanced damage levels in HPV- but only rarely in HPV+ OPSCC cultures. HPV-positive head and neck squamous cel...

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Veröffentlicht in:	Radiotherapy and oncology 2022-03, Vol.168, p.138-146
Hauptverfasser:	Zech, Henrike Barbara, Berger, Joanna, Mansour, Wael Yassin, Nordquist, Lena, von Bargen, Clara Marie, Bußmann, Lara, Oetting, Agnes, Christiansen, Sabrina, Möckelmann, Nikolaus, Böttcher, Arne, Busch, Chia-Jung, Petersen, Cordula, Betz, Christian, Rothkamm, Kai, Kriegs, Malte, Köcher, Sabrina, Rieckmann, Thorsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor DNA DNA double-strand break repair DNA Repair Ex vivo culture Head and Neck Neoplasms - genetics Head and Neck Neoplasms - radiotherapy HPV Humans OPSCC Oropharyngeal Neoplasms - radiotherapy Oropharynx - metabolism Papillomavirus Infections - complications Papillomavirus Infections - metabolism Radiation sensitivity
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