Targeting lipophagy as a potential therapeutic strategy for nonalcoholic fatty liver disease

[Display omitted] Nonalcoholic fatty liver disease (NAFLD) is becoming an increasingly serious disease worldwide. Unfortunately, no specific drug has been approved to treat NAFLD. Accumulating evidence suggests that lipotoxicity, which is induced by an excess of intracellular triacylglycerols (TAGs)...

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Veröffentlicht in:	Biochemical pharmacology 2022-03, Vol.197, p.114933-114933, Article 114933
Hauptverfasser:	Li, Hong-Ying, Peng, Zong-Gen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagosomes - drug effects Autophagosomes - metabolism Autophagy - drug effects Autophagy - physiology Berberine - administration & dosage Drug Delivery Systems - methods Fatty Acids, Nonesterified - antagonists & inhibitors Fatty Acids, Nonesterified - metabolism Fibroblast Growth Factors - administration & dosage Humans Lipid Metabolism - drug effects Lipid Metabolism - physiology Lipolysis - drug effects Lipolysis - physiology Lipophagy Lipotoxicity Liver - drug effects Liver - metabolism Mechanistic Target of Rapamycin Complex 1 - administration & dosage Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - metabolism Nonalcoholic fatty liver disease Signalling molecular Therapeutic target Transient Receptor Potential Channels - administration & dosage Triglycerides - antagonists & inhibitors Triglycerides - metabolism
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