Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting

Adoptive cell therapies require the recovery and expansion of highly potent tumour-infiltrating lymphocytes (TILs). However, TILs in tumours are rare and difficult to isolate efficiently, which hinders the optimization of therapeutic potency and dose. Here we show that a configurable microfluidic de...

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Veröffentlicht in:Nature biomedical engineering 2022-02, Vol.6 (2), p.108-117
Hauptverfasser: Wang, Zongjie, Ahmed, Sharif, Labib, Mahmoud, Wang, Hansen, Hu, Xiyue, Wei, Jiarun, Yao, Yuxi, Moffat, Jason, Sargent, Edward H., Kelley, Shana O.
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