Anti-allergic, anti-asthmatic and anti-inflammatory effects of an oxazolidinone hydroxamic acid derivative (PH-251) – A novel dual inhibitor of 5-lipoxygenase and mast cell degranulation

•PH-251 is a pharmacologically active oxazolidinone hydroxamic acid derivative.•PH-251 is a novel dual inhibitor of 5-Lipoxygenase and mast cell degranulation.•PH-251 has anti-allergic, anti-asthmatic and anti-inflammatory effects. We have recently reported the discovery of a series of oxazolidinone...

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Veröffentlicht in:	International immunopharmacology 2022-04, Vol.105, p.108558-108558, Article 108558
Hauptverfasser:	Ezeamuzie, Charles I., Rao, Muddanna S., El-Hashim, Ahmed Z., Philip, Elizabeth, Phillips, Oludotun A.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Lipoxygenase inhibitor Allergens Allergic inflammation Allergies Anaphylaxis Animal diseases Animal models Animals Anti-Allergic Agents - therapeutic use Anti-Asthmatic Agents - pharmacology Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Arachidonate 5-Lipoxygenase Asthma Asthma - drug therapy Biosynthesis Bone marrow Cell Degranulation Compound PH-251 Degranulation Guinea Pigs Hydroxamic acid Hydroxamic Acids - pharmacology Hydroxamic Acids - therapeutic use Immunoglobulin E In vivo methods and tests Inflammatory diseases Inhibitors Leukocytes (eosinophilic) Lipoxygenase Mast cell degranulation Mast Cells Methacholine Mice Mice, Inbred BALB C Oxazolidinone hydroxamate Oxazolidinones - pharmacology Oxindoles - pharmacology Peritonitis
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