Peptide hormone ELABELA promotes rat bone marrow-derived mesenchymal stem cell proliferation and migration by manipulating the cell cycle through the PI3K/AKT pathway under the hypoxia and ischemia microenvironment

Mesenchymal stem cells (MSCs) are emerging as a potential candidate for stem cell transplantation to repair myocardial tissue in myocardial infarctions (MI). However, there are some pivotal limitations such as poor survival and low migration capacity of MSCs in hypoxic and ischemic microenvironments...

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Veröffentlicht in:	Stem cell research & therapy 2022-01, Vol.13 (1), p.32-32, Article 32
Hauptverfasser:	Chen, Xuxiang, Zhou, Changqing, Xu, Daishi, Liu, Xin, Li, Shuangmei, Hou, Jingyu, Zhang, Kanglong, Zeng, Chaotao, Zheng, Guanghui, Wu, Haidong, Wu, Hao, Wang, Wuming, Fu, Jiaying, Wang, Tong
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Bone marrow Bone Marrow - metabolism Bone Marrow Cells Cell activation Cell adhesion & migration Cell Cycle Cell Division Cell growth Cell Hypoxia Cell migration Cell Proliferation Cell viability Cholecystokinin Flow cytometry G1 phase Glucose Heart attack Hypoxia Hypoxia - metabolism Ischemia Ischemia - metabolism Medical research Membranes Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Microenvironments Peptide Hormones - metabolism Peptide Hormones - pharmacology Peptides Phase transitions Phosphatidylinositol 3-Kinases - metabolism Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Signal Transduction Stem cell transplantation Stem cells Transplantation Variance analysis Western blotting
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