The Novel KLF4/BIG1 Regulates LPS-mediated Neuro-inflammation and Migration in BV2 Cells via PI3K/Akt/NF-kB Signaling Pathway

•BIG1 promotes LPS-mediated inflammatory cytokines production.•BIG1 facilitated LPS-mediated BV2 cell migration.•Activation of PI3K/Akt pathway reversed the protective roles of BIG1 silencing in inflammation and migration.•KLF4 transcriptionally regulated BIG1 expression in BV2 cells.•Ectopic expres...

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Veröffentlicht in:	Neuroscience 2022-04, Vol.488, p.102-111
Hauptverfasser:	You, Zhijun, Yang, Zhenzhen, Cao, Shuang, Deng, Shouheng, Chen, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	BIG1 BV2 cells Cyclooxygenase 2 - metabolism Guanine Nucleotide Exchange Factors - metabolism Humans Inflammation - chemically induced Inflammation - metabolism Interleukin-10 - metabolism Interleukin-6 - metabolism Lipopolysaccharides - metabolism Lipopolysaccharides - pharmacology Microglia - metabolism migration neuro-inflammation NF-kappa B - metabolism Phosphatidylinositol 3-Kinases - metabolism PI3K/Akt/NF-kB signaling pathway Proto-Oncogene Proteins c-akt - metabolism RNA, Messenger - metabolism Signal Transduction Tumor Necrosis Factor-alpha - metabolism
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