Fixed-dose administration and pharmacokinetically guided adjustment of busulfan dose for patients undergoing hematopoietic stem cell transplantation: a meta-analysis and cost-effectiveness analysis

This study aims to evaluate the efficacy, safety, and long-term cost-effectiveness of fixed-dose busulfan (Bu) administration and pharmacokinetically (PK) guided adjustment of Bu dose for patients who underwent hematopoietic stem cell transplantation. The efficacy and safety of both dosing strategie...

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Veröffentlicht in:	Annals of hematology 2022-03, Vol.101 (3), p.667-679
Hauptverfasser:	Chen, Tingting, Chen, Chaoxin, He, Xin, Guo, Jianming, Liu, Maobai, Zheng, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Busulfan - administration & dosage Busulfan - economics Busulfan - pharmacokinetics Busulfan - therapeutic use Chemotherapy Cost analysis Cost-Benefit Analysis Drug dosages Graft versus host disease Graft vs Host Disease - economics Graft vs Host Disease - etiology Graft vs Host Disease - prevention & control Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - economics Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - economics Immunosuppressive Agents - pharmacokinetics Immunosuppressive Agents - therapeutic use Markov chains Medicine Medicine & Public Health Meta-analysis Metabolism Mortality Oncology Original Article Pharmacokinetics Pharmacy Probability Quality of life Quality-Adjusted Life Years Safety Sensitivity analysis Software Stem cell transplantation Stem cells Systematic review
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