Hypoxia pretreatment improves the therapeutic potential of bone marrow mesenchymal stem cells in hindlimb ischemia via upregulation of NRG-1

Mesenchymal stem cells (MSCs) are considered a promising treatment for ischemic diseases, but their use is limited due to poor survival after injection. Hypoxia can significantly enhance the survival of MSCs. This study aimed to investigate hypoxia pretreatment of bone marrow mesenchymal stem cells...

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Veröffentlicht in:	Cell and tissue research 2022-04, Vol.388 (1), p.105-116
Hauptverfasser:	Peng, Xitao, Liang, Bing, Wang, Haisheng, Hou, Jingyuan, Yuan, Qidong
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Angiogenesis Animals Biomedical and Life Sciences Biomedicine Blood flow Bone marrow Bone Marrow Cells - metabolism Cell Hypoxia Cell proliferation Cells, Cultured Endothelial cells Health aspects Hindlimb Human Genetics Human Umbilical Vein Endothelial Cells - metabolism Humans Hypoxia Injection Ischemia Ischemia - therapy Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mice Molecular Medicine Muscles Neovascularization, Physiologic Neuregulin-1 - genetics Phosphatidylinositol 3-Kinases - metabolism Proteomics Regular Article Reperfusion Skeletal muscle Stem cell transplantation Stem cells Umbilical vein Up-Regulation
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