Linc00852 from cisplatin-resistant gastric cancer cell-derived exosomes regulates COMMD7 to promote cisplatin resistance of recipient cells through microRNA-514a-5p

Objective Cisplatin (DDP)-based chemotherapy is commonly referred to as advanced gastric cancer (GC). The purpose of this study was to unravel whether Linc00852 from DDP-resistant tumor cell-derived exosomes (Exos) promotes DDP resistance of GC cells. Methods Reverse transcription quantitative polym...

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Veröffentlicht in:	Cell biology and toxicology 2023-04, Vol.39 (2), p.483-496
Hauptverfasser:	Cao, Shuguang, Fu, Beilei, Cai, Jing, Zhang, Dingli, Wang, Chenxing, Wu, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Apoptosis Assaying BAX protein Bcl-2 protein Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Chemotherapy Cisplatin Cisplatin - pharmacology Drug resistance Drug Resistance, Neoplasm - genetics Exosomes Exosomes - genetics Exosomes - metabolism Flow cytometry Gastric cancer Humans In vivo methods and tests Life Sciences MicroRNAs - genetics MicroRNAs - metabolism miRNA Original Article Pharmacology/Toxicology Polymerase chain reaction Proteins Reporter gene Reverse transcription Ribonucleic acid RNA RNA, Messenger - metabolism Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - pathology Tumors Xenotransplantation
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