Bone erosions by MRI in first-degree relatives of patients with RA: an exploratory study
Introduction/objectives First-degree relatives (FDR) of patients with rheumatoid arthritis (RA) are at increased risk of RA diagnosis. Magnetic resonance imaging (MRI) has been proposed as a useful tool to detect subclinical synovitis and bone abnormalities as predictors of progression to RA. The pr...
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| Veröffentlicht in: | Clinical rheumatology 2022-05, Vol.41 (5), p.1343-1348 |
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| creator | Vega-Morales, David del Carmen Larios-Forte, María Pérez-Barbosa, Lorena Esquivel-Valerio, Jorge Antonio Garza-Elizondo, Mario Alberto Skinner-Taylor, Cassandra Michelle Vázquez-Fuentes, Brenda Roxana Flores-Alvarado, Diana Elsa Villarreal-Alarcón, Miguel Ángel de Jesús Hernández-Galarza, Iván Lozano-Plata, Luis Iván Castañeda-Martínez, Martha Mariana Castañeda-Martínez, Diana Daniela Herrera-Sandate, Pablo Cardenas-de la Garza, Jesus Alberto Galarza-Delgado, Dionicio Ángel |
| description | Introduction/objectives
First-degree relatives (FDR) of patients with rheumatoid arthritis (RA) are at increased risk of RA diagnosis. Magnetic resonance imaging (MRI) has been proposed as a useful tool to detect subclinical synovitis and bone abnormalities as predictors of progression to RA. The presence of grade ≥ 2 bone erosions in RA MRI scoring system (RAMRIS) was reported to be RA-specific. We aim to describe the prevalence and characteristics of MRI findings in RA patients and FDR.
Methods
A cross-sectional and exploratory study of 60 individuals was performed in 38 RA patients and 22 FDR with hand arthralgia without clinical arthritis and positive rheumatoid factor or anticitrullinated protein antibodies. All patients underwent an MRI and were evaluated for synovitis, bone erosion, and bone marrow edema. We evaluated second to fifth metacarpophalangeal joints of the dominant hand according to RAMRIS.
Results
Among the total population, eighteen (30%) subjects had grade ≥ 2 bone erosions, and 42 (70%) had at least one erosion of any grade. In patients with grade ≥ 2 bone erosions, 12 (31.6%) were from RA patients and 6 (27.2%) from FDR (
p
= 0.72). In patients with erosions of any grade, 26 (68.4%) were from RA patients and 15 (68.2%) were from FDR (
p
= 0.98).
Conclusion
A high prevalence of bone erosions was found in RA patients’ FDR who had symptoms without clinical arthritis and positive serology. MRI might be helpful in this population for an early detection of RA-specific erosions. The prognosis and the treatment decisions in these subjects should be elucidated.
Key points:
• First-degree relatives (FDR) of rheumatoid arthritis (RA) patients with positive serology and joint symptoms constitute a select subpopulation of individuals with an increased risk of developing RA.
• Magnetic resonance imaging (MRI) of FDR shows a high prevalence of bone erosions of any grade, grade
≥
2 erosions, and synovitis.
• MRI might be helpful in FDR of RA patients to screen for the presence of RA-specific erosions or clinically undetectable synovitis. |
| doi_str_mv | 10.1007/s10067-021-06028-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2623890801</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2657511011</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-cf4cdbcf0c911d87ca378086cae0cf217d3bf0f44abf74ee3a05b1639bd2c1e03</originalsourceid><addsrcrecordid>eNp9kE1LHTEUhoO06PXjD7iQQDfdpJ583EnGnZX6ARZBFNyFTOZER-ZOrslM7f33Rq-t0EU3SSDP-57DQ8g-h28cQB_mclaageAMKhCGqQ0y40oqVteq_kRmoDUwyWuzRbZzfgQoUM03yZacgzEC9IzcfY8DUkwxd3HItFnRn9cXtBto6FIeWYv3CZEm7N3Y_cJMY6DL8sRhzPS5Gx_o9fERdQPF38s-JjfGtKJ5nNrVLvkcXJ9x7_3eIbenP25Oztnl1dnFyfEl81JUI_NB-bbxAXzNeWu0d1IbMJV3CD4IrlvZBAhKuSZohSgdzBteybpphecIcod8XfcuU3yaMI920WWPfe8GjFO2ohLS1GCAF_TLP-hjnNJQtivUXM85B_5KiTXli5ScMNhl6hYurSwH--rdrr3b4t2-ebeqhA7eq6dmge3fyB_RBZBrIJev4R7Tx-z_1L4AhPKNqA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2657511011</pqid></control><display><type>article</type><title>Bone erosions by MRI in first-degree relatives of patients with RA: an exploratory study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Vega-Morales, David ; del Carmen Larios-Forte, María ; Pérez-Barbosa, Lorena ; Esquivel-Valerio, Jorge Antonio ; Garza-Elizondo, Mario Alberto ; Skinner-Taylor, Cassandra Michelle ; Vázquez-Fuentes, Brenda Roxana ; Flores-Alvarado, Diana Elsa ; Villarreal-Alarcón, Miguel Ángel ; de Jesús Hernández-Galarza, Iván ; Lozano-Plata, Luis Iván ; Castañeda-Martínez, Martha Mariana ; Castañeda-Martínez, Diana Daniela ; Herrera-Sandate, Pablo ; Cardenas-de la Garza, Jesus Alberto ; Galarza-Delgado, Dionicio Ángel</creator><creatorcontrib>Vega-Morales, David ; del Carmen Larios-Forte, María ; Pérez-Barbosa, Lorena ; Esquivel-Valerio, Jorge Antonio ; Garza-Elizondo, Mario Alberto ; Skinner-Taylor, Cassandra Michelle ; Vázquez-Fuentes, Brenda Roxana ; Flores-Alvarado, Diana Elsa ; Villarreal-Alarcón, Miguel Ángel ; de Jesús Hernández-Galarza, Iván ; Lozano-Plata, Luis Iván ; Castañeda-Martínez, Martha Mariana ; Castañeda-Martínez, Diana Daniela ; Herrera-Sandate, Pablo ; Cardenas-de la Garza, Jesus Alberto ; Galarza-Delgado, Dionicio Ángel</creatorcontrib><description>Introduction/objectives
First-degree relatives (FDR) of patients with rheumatoid arthritis (RA) are at increased risk of RA diagnosis. Magnetic resonance imaging (MRI) has been proposed as a useful tool to detect subclinical synovitis and bone abnormalities as predictors of progression to RA. The presence of grade ≥ 2 bone erosions in RA MRI scoring system (RAMRIS) was reported to be RA-specific. We aim to describe the prevalence and characteristics of MRI findings in RA patients and FDR.
Methods
A cross-sectional and exploratory study of 60 individuals was performed in 38 RA patients and 22 FDR with hand arthralgia without clinical arthritis and positive rheumatoid factor or anticitrullinated protein antibodies. All patients underwent an MRI and were evaluated for synovitis, bone erosion, and bone marrow edema. We evaluated second to fifth metacarpophalangeal joints of the dominant hand according to RAMRIS.
Results
Among the total population, eighteen (30%) subjects had grade ≥ 2 bone erosions, and 42 (70%) had at least one erosion of any grade. In patients with grade ≥ 2 bone erosions, 12 (31.6%) were from RA patients and 6 (27.2%) from FDR (
p
= 0.72). In patients with erosions of any grade, 26 (68.4%) were from RA patients and 15 (68.2%) were from FDR (
p
= 0.98).
Conclusion
A high prevalence of bone erosions was found in RA patients’ FDR who had symptoms without clinical arthritis and positive serology. MRI might be helpful in this population for an early detection of RA-specific erosions. The prognosis and the treatment decisions in these subjects should be elucidated.
Key points:
• First-degree relatives (FDR) of rheumatoid arthritis (RA) patients with positive serology and joint symptoms constitute a select subpopulation of individuals with an increased risk of developing RA.
• Magnetic resonance imaging (MRI) of FDR shows a high prevalence of bone erosions of any grade, grade
≥
2 erosions, and synovitis.
• MRI might be helpful in FDR of RA patients to screen for the presence of RA-specific erosions or clinically undetectable synovitis.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-021-06028-4</identifier><identifier>PMID: 35088207</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Arthralgia ; Arthritis, Rheumatoid - diagnosis ; Bone imaging ; Bone marrow ; Cross-Sectional Studies ; Edema ; Humans ; Joint diseases ; Magnetic Resonance Imaging ; Medicine ; Medicine & Public Health ; Metacarpophalangeal Joint - diagnostic imaging ; Metacarpophalangeal Joint - pathology ; Original Article ; Patients ; Rheumatoid arthritis ; Rheumatoid factor ; Rheumatology ; Serology ; Severity of Illness Index ; Synovitis ; Synovitis - diagnosis ; Wrist Joint - pathology</subject><ispartof>Clinical rheumatology, 2022-05, Vol.41 (5), p.1343-1348</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2021</rights><rights>2021. International League of Associations for Rheumatology (ILAR).</rights><rights>International League of Associations for Rheumatology (ILAR) 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-cf4cdbcf0c911d87ca378086cae0cf217d3bf0f44abf74ee3a05b1639bd2c1e03</cites><orcidid>0000-0001-6986-5377 ; 0000-0002-3124-0395 ; 0000-0001-5033-9588 ; 0000-0001-9714-2109 ; 0000-0003-1181-4977 ; 0000-0003-4822-0777 ; 0000-0001-9999-0179 ; 0000-0003-0651-2202 ; 0000-0001-5480-3050 ; 0000-0001-9597-8789 ; 0000-0001-8158-7170 ; 0000-0002-3711-4883 ; 0000-0002-5099-0079 ; 0000-0002-1800-0020 ; 0000-0002-3258-881X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-021-06028-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-021-06028-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35088207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vega-Morales, David</creatorcontrib><creatorcontrib>del Carmen Larios-Forte, María</creatorcontrib><creatorcontrib>Pérez-Barbosa, Lorena</creatorcontrib><creatorcontrib>Esquivel-Valerio, Jorge Antonio</creatorcontrib><creatorcontrib>Garza-Elizondo, Mario Alberto</creatorcontrib><creatorcontrib>Skinner-Taylor, Cassandra Michelle</creatorcontrib><creatorcontrib>Vázquez-Fuentes, Brenda Roxana</creatorcontrib><creatorcontrib>Flores-Alvarado, Diana Elsa</creatorcontrib><creatorcontrib>Villarreal-Alarcón, Miguel Ángel</creatorcontrib><creatorcontrib>de Jesús Hernández-Galarza, Iván</creatorcontrib><creatorcontrib>Lozano-Plata, Luis Iván</creatorcontrib><creatorcontrib>Castañeda-Martínez, Martha Mariana</creatorcontrib><creatorcontrib>Castañeda-Martínez, Diana Daniela</creatorcontrib><creatorcontrib>Herrera-Sandate, Pablo</creatorcontrib><creatorcontrib>Cardenas-de la Garza, Jesus Alberto</creatorcontrib><creatorcontrib>Galarza-Delgado, Dionicio Ángel</creatorcontrib><title>Bone erosions by MRI in first-degree relatives of patients with RA: an exploratory study</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Introduction/objectives
First-degree relatives (FDR) of patients with rheumatoid arthritis (RA) are at increased risk of RA diagnosis. Magnetic resonance imaging (MRI) has been proposed as a useful tool to detect subclinical synovitis and bone abnormalities as predictors of progression to RA. The presence of grade ≥ 2 bone erosions in RA MRI scoring system (RAMRIS) was reported to be RA-specific. We aim to describe the prevalence and characteristics of MRI findings in RA patients and FDR.
Methods
A cross-sectional and exploratory study of 60 individuals was performed in 38 RA patients and 22 FDR with hand arthralgia without clinical arthritis and positive rheumatoid factor or anticitrullinated protein antibodies. All patients underwent an MRI and were evaluated for synovitis, bone erosion, and bone marrow edema. We evaluated second to fifth metacarpophalangeal joints of the dominant hand according to RAMRIS.
Results
Among the total population, eighteen (30%) subjects had grade ≥ 2 bone erosions, and 42 (70%) had at least one erosion of any grade. In patients with grade ≥ 2 bone erosions, 12 (31.6%) were from RA patients and 6 (27.2%) from FDR (
p
= 0.72). In patients with erosions of any grade, 26 (68.4%) were from RA patients and 15 (68.2%) were from FDR (
p
= 0.98).
Conclusion
A high prevalence of bone erosions was found in RA patients’ FDR who had symptoms without clinical arthritis and positive serology. MRI might be helpful in this population for an early detection of RA-specific erosions. The prognosis and the treatment decisions in these subjects should be elucidated.
Key points:
• First-degree relatives (FDR) of rheumatoid arthritis (RA) patients with positive serology and joint symptoms constitute a select subpopulation of individuals with an increased risk of developing RA.
• Magnetic resonance imaging (MRI) of FDR shows a high prevalence of bone erosions of any grade, grade
≥
2 erosions, and synovitis.
• MRI might be helpful in FDR of RA patients to screen for the presence of RA-specific erosions or clinically undetectable synovitis.</description><subject>Arthralgia</subject><subject>Arthritis, Rheumatoid - diagnosis</subject><subject>Bone imaging</subject><subject>Bone marrow</subject><subject>Cross-Sectional Studies</subject><subject>Edema</subject><subject>Humans</subject><subject>Joint diseases</subject><subject>Magnetic Resonance Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metacarpophalangeal Joint - diagnostic imaging</subject><subject>Metacarpophalangeal Joint - pathology</subject><subject>Original Article</subject><subject>Patients</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid factor</subject><subject>Rheumatology</subject><subject>Serology</subject><subject>Severity of Illness Index</subject><subject>Synovitis</subject><subject>Synovitis - diagnosis</subject><subject>Wrist Joint - 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Alberto</creator><creator>Skinner-Taylor, Cassandra Michelle</creator><creator>Vázquez-Fuentes, Brenda Roxana</creator><creator>Flores-Alvarado, Diana Elsa</creator><creator>Villarreal-Alarcón, Miguel Ángel</creator><creator>de Jesús Hernández-Galarza, Iván</creator><creator>Lozano-Plata, Luis Iván</creator><creator>Castañeda-Martínez, Martha Mariana</creator><creator>Castañeda-Martínez, Diana Daniela</creator><creator>Herrera-Sandate, Pablo</creator><creator>Cardenas-de la Garza, Jesus Alberto</creator><creator>Galarza-Delgado, Dionicio Ángel</creator><general>Springer International Publishing</general><general>Springer Nature 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erosions by MRI in first-degree relatives of patients with RA: an exploratory study</title><author>Vega-Morales, David ; del Carmen Larios-Forte, María ; Pérez-Barbosa, Lorena ; Esquivel-Valerio, Jorge Antonio ; Garza-Elizondo, Mario Alberto ; Skinner-Taylor, Cassandra Michelle ; Vázquez-Fuentes, Brenda Roxana ; Flores-Alvarado, Diana Elsa ; Villarreal-Alarcón, Miguel Ángel ; de Jesús Hernández-Galarza, Iván ; Lozano-Plata, Luis Iván ; Castañeda-Martínez, Martha Mariana ; Castañeda-Martínez, Diana Daniela ; Herrera-Sandate, Pablo ; Cardenas-de la Garza, Jesus Alberto ; Galarza-Delgado, Dionicio Ángel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-cf4cdbcf0c911d87ca378086cae0cf217d3bf0f44abf74ee3a05b1639bd2c1e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Arthralgia</topic><topic>Arthritis, Rheumatoid - diagnosis</topic><topic>Bone imaging</topic><topic>Bone marrow</topic><topic>Cross-Sectional Studies</topic><topic>Edema</topic><topic>Humans</topic><topic>Joint diseases</topic><topic>Magnetic Resonance Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metacarpophalangeal Joint - diagnostic imaging</topic><topic>Metacarpophalangeal Joint - pathology</topic><topic>Original Article</topic><topic>Patients</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid factor</topic><topic>Rheumatology</topic><topic>Serology</topic><topic>Severity of Illness Index</topic><topic>Synovitis</topic><topic>Synovitis - diagnosis</topic><topic>Wrist Joint - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vega-Morales, David</creatorcontrib><creatorcontrib>del Carmen Larios-Forte, María</creatorcontrib><creatorcontrib>Pérez-Barbosa, Lorena</creatorcontrib><creatorcontrib>Esquivel-Valerio, Jorge Antonio</creatorcontrib><creatorcontrib>Garza-Elizondo, Mario Alberto</creatorcontrib><creatorcontrib>Skinner-Taylor, Cassandra Michelle</creatorcontrib><creatorcontrib>Vázquez-Fuentes, Brenda Roxana</creatorcontrib><creatorcontrib>Flores-Alvarado, Diana Elsa</creatorcontrib><creatorcontrib>Villarreal-Alarcón, Miguel Ángel</creatorcontrib><creatorcontrib>de Jesús Hernández-Galarza, Iván</creatorcontrib><creatorcontrib>Lozano-Plata, Luis Iván</creatorcontrib><creatorcontrib>Castañeda-Martínez, Martha Mariana</creatorcontrib><creatorcontrib>Castañeda-Martínez, Diana Daniela</creatorcontrib><creatorcontrib>Herrera-Sandate, Pablo</creatorcontrib><creatorcontrib>Cardenas-de la Garza, Jesus Alberto</creatorcontrib><creatorcontrib>Galarza-Delgado, Dionicio Ángel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vega-Morales, David</au><au>del Carmen Larios-Forte, María</au><au>Pérez-Barbosa, Lorena</au><au>Esquivel-Valerio, Jorge Antonio</au><au>Garza-Elizondo, Mario Alberto</au><au>Skinner-Taylor, Cassandra Michelle</au><au>Vázquez-Fuentes, Brenda Roxana</au><au>Flores-Alvarado, Diana Elsa</au><au>Villarreal-Alarcón, Miguel Ángel</au><au>de Jesús Hernández-Galarza, Iván</au><au>Lozano-Plata, Luis Iván</au><au>Castañeda-Martínez, Martha Mariana</au><au>Castañeda-Martínez, Diana Daniela</au><au>Herrera-Sandate, Pablo</au><au>Cardenas-de la Garza, Jesus Alberto</au><au>Galarza-Delgado, Dionicio Ángel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone erosions by MRI in first-degree relatives of patients with RA: an exploratory study</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2022-05</date><risdate>2022</risdate><volume>41</volume><issue>5</issue><spage>1343</spage><epage>1348</epage><pages>1343-1348</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>Introduction/objectives
First-degree relatives (FDR) of patients with rheumatoid arthritis (RA) are at increased risk of RA diagnosis. Magnetic resonance imaging (MRI) has been proposed as a useful tool to detect subclinical synovitis and bone abnormalities as predictors of progression to RA. The presence of grade ≥ 2 bone erosions in RA MRI scoring system (RAMRIS) was reported to be RA-specific. We aim to describe the prevalence and characteristics of MRI findings in RA patients and FDR.
Methods
A cross-sectional and exploratory study of 60 individuals was performed in 38 RA patients and 22 FDR with hand arthralgia without clinical arthritis and positive rheumatoid factor or anticitrullinated protein antibodies. All patients underwent an MRI and were evaluated for synovitis, bone erosion, and bone marrow edema. We evaluated second to fifth metacarpophalangeal joints of the dominant hand according to RAMRIS.
Results
Among the total population, eighteen (30%) subjects had grade ≥ 2 bone erosions, and 42 (70%) had at least one erosion of any grade. In patients with grade ≥ 2 bone erosions, 12 (31.6%) were from RA patients and 6 (27.2%) from FDR (
p
= 0.72). In patients with erosions of any grade, 26 (68.4%) were from RA patients and 15 (68.2%) were from FDR (
p
= 0.98).
Conclusion
A high prevalence of bone erosions was found in RA patients’ FDR who had symptoms without clinical arthritis and positive serology. MRI might be helpful in this population for an early detection of RA-specific erosions. The prognosis and the treatment decisions in these subjects should be elucidated.
Key points:
• First-degree relatives (FDR) of rheumatoid arthritis (RA) patients with positive serology and joint symptoms constitute a select subpopulation of individuals with an increased risk of developing RA.
• Magnetic resonance imaging (MRI) of FDR shows a high prevalence of bone erosions of any grade, grade
≥
2 erosions, and synovitis.
• MRI might be helpful in FDR of RA patients to screen for the presence of RA-specific erosions or clinically undetectable synovitis.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>35088207</pmid><doi>10.1007/s10067-021-06028-4</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-6986-5377</orcidid><orcidid>https://orcid.org/0000-0002-3124-0395</orcidid><orcidid>https://orcid.org/0000-0001-5033-9588</orcidid><orcidid>https://orcid.org/0000-0001-9714-2109</orcidid><orcidid>https://orcid.org/0000-0003-1181-4977</orcidid><orcidid>https://orcid.org/0000-0003-4822-0777</orcidid><orcidid>https://orcid.org/0000-0001-9999-0179</orcidid><orcidid>https://orcid.org/0000-0003-0651-2202</orcidid><orcidid>https://orcid.org/0000-0001-5480-3050</orcidid><orcidid>https://orcid.org/0000-0001-9597-8789</orcidid><orcidid>https://orcid.org/0000-0001-8158-7170</orcidid><orcidid>https://orcid.org/0000-0002-3711-4883</orcidid><orcidid>https://orcid.org/0000-0002-5099-0079</orcidid><orcidid>https://orcid.org/0000-0002-1800-0020</orcidid><orcidid>https://orcid.org/0000-0002-3258-881X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0770-3198 |
| ispartof | Clinical rheumatology, 2022-05, Vol.41 (5), p.1343-1348 |
| issn | 0770-3198 1434-9949 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2623890801 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Arthralgia Arthritis, Rheumatoid - diagnosis Bone imaging Bone marrow Cross-Sectional Studies Edema Humans Joint diseases Magnetic Resonance Imaging Medicine Medicine & Public Health Metacarpophalangeal Joint - diagnostic imaging Metacarpophalangeal Joint - pathology Original Article Patients Rheumatoid arthritis Rheumatoid factor Rheumatology Serology Severity of Illness Index Synovitis Synovitis - diagnosis Wrist Joint - pathology |
| title | Bone erosions by MRI in first-degree relatives of patients with RA: an exploratory study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T08%3A03%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bone%20erosions%20by%20MRI%20in%20first-degree%20relatives%20of%20patients%20with%20RA:%20an%20exploratory%20study&rft.jtitle=Clinical%20rheumatology&rft.au=Vega-Morales,%20David&rft.date=2022-05&rft.volume=41&rft.issue=5&rft.spage=1343&rft.epage=1348&rft.pages=1343-1348&rft.issn=0770-3198&rft.eissn=1434-9949&rft_id=info:doi/10.1007/s10067-021-06028-4&rft_dat=%3Cproquest_cross%3E2657511011%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2657511011&rft_id=info:pmid/35088207&rfr_iscdi=true |