In Vivo 13C Magnetic Resonance Spectroscopy for Assessing Brain Biochemistry in Health and Disease
Magnetic resonance spectroscopy (MRS) is a non-invasive technique that contributes to the elucidation of brain biochemistry. 13 C MRS enables the detection of specific neurochemicals and their neuroenergetic correlation with neuronal function. The synergistic outcome of 13 C MRS and the infusion of...
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| Veröffentlicht in: | Neurochemical research 2022-05, Vol.47 (5), p.1183-1201 |
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| creator | Mandal, Pravat K. Guha Roy, Rimil Samkaria, Avantika Maroon, Joseph C. Arora, Yashika |
| description | Magnetic resonance spectroscopy (MRS) is a non-invasive technique that contributes to the elucidation of brain biochemistry.
13
C MRS enables the detection of specific neurochemicals and their neuroenergetic correlation with neuronal function. The synergistic outcome of
13
C MRS and the infusion of
13
C-labeled substrates provide an understanding of neurometabolism and the role of glutamate/gamma-aminobutyric acid (GABA) neurotransmission in diseases, such as Alzheimer’s disease, schizophrenia, and bipolar disorder. Moreover,
13
C MRS provides a window into the altered flux rate of different pathways, including the tricarboxylic acid cycle (TCA) and the glutamate/glutamine/GABA cycle, in health and in various diseases. Notably, the metabolic flux rate of the TCA cycle often decreases in neurodegenerative diseases. Additionally,
13
C MRS can be used to investigate several psychiatric and neurological disorders as it directly reflects the real-time production and alterations of key brain metabolites. This review aims to highlight the chronology, the technological advancements, and the applications of
13
C MRS in various brain diseases. |
| doi_str_mv | 10.1007/s11064-022-03538-8 |
| format | Article |
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13
C MRS enables the detection of specific neurochemicals and their neuroenergetic correlation with neuronal function. The synergistic outcome of
13
C MRS and the infusion of
13
C-labeled substrates provide an understanding of neurometabolism and the role of glutamate/gamma-aminobutyric acid (GABA) neurotransmission in diseases, such as Alzheimer’s disease, schizophrenia, and bipolar disorder. Moreover,
13
C MRS provides a window into the altered flux rate of different pathways, including the tricarboxylic acid cycle (TCA) and the glutamate/glutamine/GABA cycle, in health and in various diseases. Notably, the metabolic flux rate of the TCA cycle often decreases in neurodegenerative diseases. Additionally,
13
C MRS can be used to investigate several psychiatric and neurological disorders as it directly reflects the real-time production and alterations of key brain metabolites. This review aims to highlight the chronology, the technological advancements, and the applications of
13
C MRS in various brain diseases.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-022-03538-8</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alzheimer's disease ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bipolar disorder ; Brain ; Cell Biology ; Glutamine ; Magnetic resonance spectroscopy ; Mental disorders ; Metabolic flux ; Metabolites ; Neurochemistry ; Neurodegenerative diseases ; Neurological diseases ; Neurology ; Neurosciences ; Neurotransmission ; Resonance ; Review ; Schizophrenia ; Spectroscopy ; Spectrum analysis ; Substrates ; Tricarboxylic acid cycle ; γ-Aminobutyric acid</subject><ispartof>Neurochemical research, 2022-05, Vol.47 (5), p.1183-1201</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-1694c5cbbad0356708e4a262bc6e787f672a8c95666dd9f5573ee91ed0fc23cc3</citedby><cites>FETCH-LOGICAL-c282t-1694c5cbbad0356708e4a262bc6e787f672a8c95666dd9f5573ee91ed0fc23cc3</cites><orcidid>0000-0003-4999-2808</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-022-03538-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-022-03538-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Mandal, Pravat K.</creatorcontrib><creatorcontrib>Guha Roy, Rimil</creatorcontrib><creatorcontrib>Samkaria, Avantika</creatorcontrib><creatorcontrib>Maroon, Joseph C.</creatorcontrib><creatorcontrib>Arora, Yashika</creatorcontrib><title>In Vivo 13C Magnetic Resonance Spectroscopy for Assessing Brain Biochemistry in Health and Disease</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><description>Magnetic resonance spectroscopy (MRS) is a non-invasive technique that contributes to the elucidation of brain biochemistry.
13
C MRS enables the detection of specific neurochemicals and their neuroenergetic correlation with neuronal function. The synergistic outcome of
13
C MRS and the infusion of
13
C-labeled substrates provide an understanding of neurometabolism and the role of glutamate/gamma-aminobutyric acid (GABA) neurotransmission in diseases, such as Alzheimer’s disease, schizophrenia, and bipolar disorder. Moreover,
13
C MRS provides a window into the altered flux rate of different pathways, including the tricarboxylic acid cycle (TCA) and the glutamate/glutamine/GABA cycle, in health and in various diseases. Notably, the metabolic flux rate of the TCA cycle often decreases in neurodegenerative diseases. Additionally,
13
C MRS can be used to investigate several psychiatric and neurological disorders as it directly reflects the real-time production and alterations of key brain metabolites. This review aims to highlight the chronology, the technological advancements, and the applications of
13
C MRS in various brain diseases.</description><subject>Alzheimer's disease</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bipolar disorder</subject><subject>Brain</subject><subject>Cell Biology</subject><subject>Glutamine</subject><subject>Magnetic resonance spectroscopy</subject><subject>Mental disorders</subject><subject>Metabolic flux</subject><subject>Metabolites</subject><subject>Neurochemistry</subject><subject>Neurodegenerative diseases</subject><subject>Neurological diseases</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Neurotransmission</subject><subject>Resonance</subject><subject>Review</subject><subject>Schizophrenia</subject><subject>Spectroscopy</subject><subject>Spectrum analysis</subject><subject>Substrates</subject><subject>Tricarboxylic acid cycle</subject><subject>γ-Aminobutyric acid</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LAzEQhoMoWD_-gKeAFy-rk2Q3mz1q_aigCH5dQ5qdrSs1qZmt0H9vtILgwVMY8rwvMw9jBwKOBUB9QkKALguQsgBVKVOYDTYSVa0K3YDaZCNQ-VuJBrbZDtErQI5JMWLT68Cf-4_IhRrzWzcLOPSe3yPF4IJH_rBAP6RIPi5WvIuJnxIhUR9m_Cy5PvCzPvoXfOtpSCue5wm6-fDCXWj5eU_oCPfYVufmhPs_7y57urx4HE-Km7ur6_HpTeGlkUMhdFP6yk-nrs0n6BoMlk5qOfUaa1N3upbO-KbSWrdt01X5OMRGYAudl8p7tcuO1r2LFN-XSIPNW3mcz13AuCSbu5RpQBqV0cM_6GtcppC3y1RZagCoykzJNeWzAErY2UXq31xaWQH2S7tda7dZu_3Wbk0OqXWIMhxmmH6r_0l9AvdehEo</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Mandal, Pravat K.</creator><creator>Guha Roy, Rimil</creator><creator>Samkaria, Avantika</creator><creator>Maroon, Joseph C.</creator><creator>Arora, Yashika</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4999-2808</orcidid></search><sort><creationdate>20220501</creationdate><title>In Vivo 13C Magnetic Resonance Spectroscopy for Assessing Brain Biochemistry in Health and Disease</title><author>Mandal, Pravat K. ; Guha Roy, Rimil ; Samkaria, Avantika ; Maroon, Joseph C. ; Arora, Yashika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-1694c5cbbad0356708e4a262bc6e787f672a8c95666dd9f5573ee91ed0fc23cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alzheimer's disease</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bipolar disorder</topic><topic>Brain</topic><topic>Cell Biology</topic><topic>Glutamine</topic><topic>Magnetic resonance spectroscopy</topic><topic>Mental disorders</topic><topic>Metabolic flux</topic><topic>Metabolites</topic><topic>Neurochemistry</topic><topic>Neurodegenerative diseases</topic><topic>Neurological diseases</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Neurotransmission</topic><topic>Resonance</topic><topic>Review</topic><topic>Schizophrenia</topic><topic>Spectroscopy</topic><topic>Spectrum analysis</topic><topic>Substrates</topic><topic>Tricarboxylic acid cycle</topic><topic>γ-Aminobutyric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mandal, Pravat K.</creatorcontrib><creatorcontrib>Guha Roy, Rimil</creatorcontrib><creatorcontrib>Samkaria, Avantika</creatorcontrib><creatorcontrib>Maroon, Joseph C.</creatorcontrib><creatorcontrib>Arora, Yashika</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mandal, Pravat K.</au><au>Guha Roy, Rimil</au><au>Samkaria, Avantika</au><au>Maroon, Joseph C.</au><au>Arora, Yashika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vivo 13C Magnetic Resonance Spectroscopy for Assessing Brain Biochemistry in Health and Disease</atitle><jtitle>Neurochemical research</jtitle><stitle>Neurochem Res</stitle><date>2022-05-01</date><risdate>2022</risdate><volume>47</volume><issue>5</issue><spage>1183</spage><epage>1201</epage><pages>1183-1201</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>Magnetic resonance spectroscopy (MRS) is a non-invasive technique that contributes to the elucidation of brain biochemistry.
13
C MRS enables the detection of specific neurochemicals and their neuroenergetic correlation with neuronal function. The synergistic outcome of
13
C MRS and the infusion of
13
C-labeled substrates provide an understanding of neurometabolism and the role of glutamate/gamma-aminobutyric acid (GABA) neurotransmission in diseases, such as Alzheimer’s disease, schizophrenia, and bipolar disorder. Moreover,
13
C MRS provides a window into the altered flux rate of different pathways, including the tricarboxylic acid cycle (TCA) and the glutamate/glutamine/GABA cycle, in health and in various diseases. Notably, the metabolic flux rate of the TCA cycle often decreases in neurodegenerative diseases. Additionally,
13
C MRS can be used to investigate several psychiatric and neurological disorders as it directly reflects the real-time production and alterations of key brain metabolites. This review aims to highlight the chronology, the technological advancements, and the applications of
13
C MRS in various brain diseases.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11064-022-03538-8</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0003-4999-2808</orcidid></addata></record> |
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| ispartof | Neurochemical research, 2022-05, Vol.47 (5), p.1183-1201 |
| issn | 0364-3190 1573-6903 |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Alzheimer's disease Biochemistry Biomedical and Life Sciences Biomedicine Bipolar disorder Brain Cell Biology Glutamine Magnetic resonance spectroscopy Mental disorders Metabolic flux Metabolites Neurochemistry Neurodegenerative diseases Neurological diseases Neurology Neurosciences Neurotransmission Resonance Review Schizophrenia Spectroscopy Spectrum analysis Substrates Tricarboxylic acid cycle γ-Aminobutyric acid |
| title | In Vivo 13C Magnetic Resonance Spectroscopy for Assessing Brain Biochemistry in Health and Disease |
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