Biomarkers for predicting nucleos(t)ide analogs discontinuation and hepatitis B virus recurrence after drug withdrawal in chronic hepatitis B patients
Aim To summarize HBV‐related biomarkers predicting nucleos(t)ide analogs (NAs) discontinuation and hepatitis B virus (HBV) recurrence after drug withdrawal in chronic hepatitis B (CHB) patients, providing references for clinical medication, so as to manage CHB patients more scientifically. Methods R...
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Veröffentlicht in: | Hepatology research 2022-04, Vol.52 (4), p.337-351 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Aim
To summarize HBV‐related biomarkers predicting nucleos(t)ide analogs (NAs) discontinuation and hepatitis B virus (HBV) recurrence after drug withdrawal in chronic hepatitis B (CHB) patients, providing references for clinical medication, so as to manage CHB patients more scientifically.
Methods
Related pieces of literature were retrieved in PubMed and the results were sorted out. We then analyzed and summarized these articles.
Results
We found that HBV related biomarkers maybe could predict NAs withdrawal safely and the possibility of relapse after treatment cessation, including hepatitis B e antigen (HBeAg), hepatitis B surface antigen (HBsAg), HBV DNA, HBV RNA, pregenomic‐RNA (pgRNA), hepatitis B core‐related antigen (HBcrAg), hepatitis B core antibody (anti‐HBc), and models containing several indicators for predicting the effectiveness of treatment.
Conclusions
HBV DNA, HBV RNA, pgRNA, HBcrAg, anti‐HBc, as well as the prediction models formed by several biomarkers could predict the safe discontinuation of NAs before HBsAg loss and recurrence. |
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ISSN: | 1386-6346 1872-034X |
DOI: | 10.1111/hepr.13749 |