PROGNOSIS AND PREVENTION OF UTERUS BLEEDINGS IN EARLY POSTPARTUM PERIOD FOR WOMEN WITH IDIOPATHIC ARTERIAL HYPOTENSION

The aim: To establish the effectiveness of thromboelastography (TEG) and tranexamic acid (TXA) for prognosis and prevention of early postpartum period bleedings (PPB) for postpartum women with idiopathic arterial hypotension (IAH). Materials and methods: Coagulogical research was conducted (coaugolo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Wiadomości lekarskie (1960) 2022, Vol.75 (1), p.102-106
Hauptverfasser: Markin, Leonid B, Popovych, Olena I, Popovych, Alla I
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 106
container_issue 1
container_start_page 102
container_title Wiadomości lekarskie (1960)
container_volume 75
creator Markin, Leonid B
Popovych, Olena I
Popovych, Alla I
description The aim: To establish the effectiveness of thromboelastography (TEG) and tranexamic acid (TXA) for prognosis and prevention of early postpartum period bleedings (PPB) for postpartum women with idiopathic arterial hypotension (IAH). Materials and methods: Coagulogical research was conducted (coaugologram screening, dynamic function of platelets under the influence of adenosine diphosphate (ADP) (visual assessment), measurement of soluble fibrin-monomer complexes (FMC) and TEG of 36 in parturient women during the I chilbirth period with arterial hypotension. 14 parturient women with normal fibrinolysis were included into the first observation group; The second group includes 22 parturient women with TEG results which show signs of hyperfibrinolysis. Further, in cases when stronger fibrinolysis was detected during the late pushing phase of childbirth period, the TXA by amount of 1,0 g IV (bolus) was injected due to bleeding prevention. TEG was repeated during early postpartum period. Results: the inhibition of platelet aggregation activity with ADP was observed in every parturient woman with IAH in the first partum period. In 61,1% cases with TEG hyperfibrinolysis were shown, which was accompanied by significant increase in FMC levels in blood. The use of TXA as PPB prevention for parturient women with IAH and hyperfibrinolysis during TEG was fully oppressing the fibrinolytic activity and was not affecting the coagulation part of hemostasis. Conclusions: hemostasis testing during childbirth based on TEG gives the ability to prognose the hemorrhagic complications in parturient women with IAH and administer their prophylaxy using TXA.
doi_str_mv 10.36740/WLek202201119
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2623889964</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2623889964</sourcerecordid><originalsourceid>FETCH-LOGICAL-c956-3d7afb54d75e8ecf988cc29a591b84828bb68b34e22c928c162d045f6f11f043</originalsourceid><addsrcrecordid>eNpVkM9PwjAUgHvQCEGuHk2PXqZtt3btcUJhTUa7bEPCadmPLkFBcBMT_3unoInv8i7f-5L3AXCD0b3LfA89rCL7QhAhCGMsLsAQIc91KPb8ARh33TPqh1GMmLgCA5ciQQhlQ_ARJ2auTapSGOgpjBP5JHWmjIZmBpeZTJYpfIyknCo9T6HSUAZJtIaxSbM4SLLlAsYyUWYKZyaBK7OQGq5UFkI1VSYOslBNYI_1SBDBcB2bTOq0t1-Dy6bYdnZ83iOQzmQ2CZ3IzNUkiJxKUOa4tV80JfVqn1puq0ZwXlVEFFTgknuc8LJkvHQ9S0glCK8wIzXyaMMajJv-_RG4O1kP7f7taLv3fLfpKrvdFq92f-xywojLuRDsG70_oVW777rWNvmh3eyK9jPHKP8JnP8L3B_cnt3HcmfrP_w3rfsFMYpuPg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2623889964</pqid></control><display><type>article</type><title>PROGNOSIS AND PREVENTION OF UTERUS BLEEDINGS IN EARLY POSTPARTUM PERIOD FOR WOMEN WITH IDIOPATHIC ARTERIAL HYPOTENSION</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Markin, Leonid B ; Popovych, Olena I ; Popovych, Alla I</creator><creatorcontrib>Markin, Leonid B ; Popovych, Olena I ; Popovych, Alla I</creatorcontrib><description>The aim: To establish the effectiveness of thromboelastography (TEG) and tranexamic acid (TXA) for prognosis and prevention of early postpartum period bleedings (PPB) for postpartum women with idiopathic arterial hypotension (IAH). Materials and methods: Coagulogical research was conducted (coaugologram screening, dynamic function of platelets under the influence of adenosine diphosphate (ADP) (visual assessment), measurement of soluble fibrin-monomer complexes (FMC) and TEG of 36 in parturient women during the I chilbirth period with arterial hypotension. 14 parturient women with normal fibrinolysis were included into the first observation group; The second group includes 22 parturient women with TEG results which show signs of hyperfibrinolysis. Further, in cases when stronger fibrinolysis was detected during the late pushing phase of childbirth period, the TXA by amount of 1,0 g IV (bolus) was injected due to bleeding prevention. TEG was repeated during early postpartum period. Results: the inhibition of platelet aggregation activity with ADP was observed in every parturient woman with IAH in the first partum period. In 61,1% cases with TEG hyperfibrinolysis were shown, which was accompanied by significant increase in FMC levels in blood. The use of TXA as PPB prevention for parturient women with IAH and hyperfibrinolysis during TEG was fully oppressing the fibrinolytic activity and was not affecting the coagulation part of hemostasis. Conclusions: hemostasis testing during childbirth based on TEG gives the ability to prognose the hemorrhagic complications in parturient women with IAH and administer their prophylaxy using TXA.</description><identifier>ISSN: 0043-5147</identifier><identifier>DOI: 10.36740/WLek202201119</identifier><identifier>PMID: 35092256</identifier><language>eng</language><publisher>Poland</publisher><subject>Female ; Humans ; Hypotension ; Postpartum Period ; Prognosis ; Thrombelastography ; Uterus</subject><ispartof>Wiadomości lekarskie (1960), 2022, Vol.75 (1), p.102-106</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c956-3d7afb54d75e8ecf988cc29a591b84828bb68b34e22c928c162d045f6f11f043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4021,27921,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35092256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Markin, Leonid B</creatorcontrib><creatorcontrib>Popovych, Olena I</creatorcontrib><creatorcontrib>Popovych, Alla I</creatorcontrib><title>PROGNOSIS AND PREVENTION OF UTERUS BLEEDINGS IN EARLY POSTPARTUM PERIOD FOR WOMEN WITH IDIOPATHIC ARTERIAL HYPOTENSION</title><title>Wiadomości lekarskie (1960)</title><addtitle>Wiad Lek</addtitle><description>The aim: To establish the effectiveness of thromboelastography (TEG) and tranexamic acid (TXA) for prognosis and prevention of early postpartum period bleedings (PPB) for postpartum women with idiopathic arterial hypotension (IAH). Materials and methods: Coagulogical research was conducted (coaugologram screening, dynamic function of platelets under the influence of adenosine diphosphate (ADP) (visual assessment), measurement of soluble fibrin-monomer complexes (FMC) and TEG of 36 in parturient women during the I chilbirth period with arterial hypotension. 14 parturient women with normal fibrinolysis were included into the first observation group; The second group includes 22 parturient women with TEG results which show signs of hyperfibrinolysis. Further, in cases when stronger fibrinolysis was detected during the late pushing phase of childbirth period, the TXA by amount of 1,0 g IV (bolus) was injected due to bleeding prevention. TEG was repeated during early postpartum period. Results: the inhibition of platelet aggregation activity with ADP was observed in every parturient woman with IAH in the first partum period. In 61,1% cases with TEG hyperfibrinolysis were shown, which was accompanied by significant increase in FMC levels in blood. The use of TXA as PPB prevention for parturient women with IAH and hyperfibrinolysis during TEG was fully oppressing the fibrinolytic activity and was not affecting the coagulation part of hemostasis. Conclusions: hemostasis testing during childbirth based on TEG gives the ability to prognose the hemorrhagic complications in parturient women with IAH and administer their prophylaxy using TXA.</description><subject>Female</subject><subject>Humans</subject><subject>Hypotension</subject><subject>Postpartum Period</subject><subject>Prognosis</subject><subject>Thrombelastography</subject><subject>Uterus</subject><issn>0043-5147</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM9PwjAUgHvQCEGuHk2PXqZtt3btcUJhTUa7bEPCadmPLkFBcBMT_3unoInv8i7f-5L3AXCD0b3LfA89rCL7QhAhCGMsLsAQIc91KPb8ARh33TPqh1GMmLgCA5ciQQhlQ_ARJ2auTapSGOgpjBP5JHWmjIZmBpeZTJYpfIyknCo9T6HSUAZJtIaxSbM4SLLlAsYyUWYKZyaBK7OQGq5UFkI1VSYOslBNYI_1SBDBcB2bTOq0t1-Dy6bYdnZ83iOQzmQ2CZ3IzNUkiJxKUOa4tV80JfVqn1puq0ZwXlVEFFTgknuc8LJkvHQ9S0glCK8wIzXyaMMajJv-_RG4O1kP7f7taLv3fLfpKrvdFq92f-xywojLuRDsG70_oVW777rWNvmh3eyK9jPHKP8JnP8L3B_cnt3HcmfrP_w3rfsFMYpuPg</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Markin, Leonid B</creator><creator>Popovych, Olena I</creator><creator>Popovych, Alla I</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2022</creationdate><title>PROGNOSIS AND PREVENTION OF UTERUS BLEEDINGS IN EARLY POSTPARTUM PERIOD FOR WOMEN WITH IDIOPATHIC ARTERIAL HYPOTENSION</title><author>Markin, Leonid B ; Popovych, Olena I ; Popovych, Alla I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c956-3d7afb54d75e8ecf988cc29a591b84828bb68b34e22c928c162d045f6f11f043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Female</topic><topic>Humans</topic><topic>Hypotension</topic><topic>Postpartum Period</topic><topic>Prognosis</topic><topic>Thrombelastography</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Markin, Leonid B</creatorcontrib><creatorcontrib>Popovych, Olena I</creatorcontrib><creatorcontrib>Popovych, Alla I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Wiadomości lekarskie (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Markin, Leonid B</au><au>Popovych, Olena I</au><au>Popovych, Alla I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PROGNOSIS AND PREVENTION OF UTERUS BLEEDINGS IN EARLY POSTPARTUM PERIOD FOR WOMEN WITH IDIOPATHIC ARTERIAL HYPOTENSION</atitle><jtitle>Wiadomości lekarskie (1960)</jtitle><addtitle>Wiad Lek</addtitle><date>2022</date><risdate>2022</risdate><volume>75</volume><issue>1</issue><spage>102</spage><epage>106</epage><pages>102-106</pages><issn>0043-5147</issn><abstract>The aim: To establish the effectiveness of thromboelastography (TEG) and tranexamic acid (TXA) for prognosis and prevention of early postpartum period bleedings (PPB) for postpartum women with idiopathic arterial hypotension (IAH). Materials and methods: Coagulogical research was conducted (coaugologram screening, dynamic function of platelets under the influence of adenosine diphosphate (ADP) (visual assessment), measurement of soluble fibrin-monomer complexes (FMC) and TEG of 36 in parturient women during the I chilbirth period with arterial hypotension. 14 parturient women with normal fibrinolysis were included into the first observation group; The second group includes 22 parturient women with TEG results which show signs of hyperfibrinolysis. Further, in cases when stronger fibrinolysis was detected during the late pushing phase of childbirth period, the TXA by amount of 1,0 g IV (bolus) was injected due to bleeding prevention. TEG was repeated during early postpartum period. Results: the inhibition of platelet aggregation activity with ADP was observed in every parturient woman with IAH in the first partum period. In 61,1% cases with TEG hyperfibrinolysis were shown, which was accompanied by significant increase in FMC levels in blood. The use of TXA as PPB prevention for parturient women with IAH and hyperfibrinolysis during TEG was fully oppressing the fibrinolytic activity and was not affecting the coagulation part of hemostasis. Conclusions: hemostasis testing during childbirth based on TEG gives the ability to prognose the hemorrhagic complications in parturient women with IAH and administer their prophylaxy using TXA.</abstract><cop>Poland</cop><pmid>35092256</pmid><doi>10.36740/WLek202201119</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0043-5147
ispartof Wiadomości lekarskie (1960), 2022, Vol.75 (1), p.102-106
issn 0043-5147
language eng
recordid cdi_proquest_miscellaneous_2623889964
source MEDLINE; Alma/SFX Local Collection
subjects Female
Humans
Hypotension
Postpartum Period
Prognosis
Thrombelastography
Uterus
title PROGNOSIS AND PREVENTION OF UTERUS BLEEDINGS IN EARLY POSTPARTUM PERIOD FOR WOMEN WITH IDIOPATHIC ARTERIAL HYPOTENSION
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T01%3A29%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PROGNOSIS%20AND%20PREVENTION%20OF%20UTERUS%20BLEEDINGS%20IN%20EARLY%20POSTPARTUM%20PERIOD%20FOR%20WOMEN%20WITH%20IDIOPATHIC%20ARTERIAL%20HYPOTENSION&rft.jtitle=Wiadomo%C5%9Bci%20lekarskie%20(1960)&rft.au=Markin,%20Leonid%20B&rft.date=2022&rft.volume=75&rft.issue=1&rft.spage=102&rft.epage=106&rft.pages=102-106&rft.issn=0043-5147&rft_id=info:doi/10.36740/WLek202201119&rft_dat=%3Cproquest_cross%3E2623889964%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2623889964&rft_id=info:pmid/35092256&rfr_iscdi=true