In Vitro Matured Human Pluripotent Stem Cell–Derived Cardiomyocytes Form Grafts With Enhanced Structure and Function in Injured Hearts

Human pluripotent stem cell (hPSC)-derived cardiomyocytes (hPSC-CMs) have tremendous promise for application in cardiac regeneration, but their translational potential is limited by an immature phenotype. We hypothesized that large-scale manufacturing of mature hPSC-CMs could be achieved through cul...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2022-05, Vol.145 (18), p.1412-1426
Hauptverfasser:	Dhahri, Wahiba, Sadikov Valdman, Tamilla, Wilkinson, Dan, Pereira, Elizabeth, Ceylan, Eylül, Andharia, Naaz, Qiang, Beiping, Masoudpour, Hassan, Wulkan, Fanny, Quesnel, Elya, Jiang, Wenlei, Funakoshi, Shunsuke, Mazine, Amine, Gomez-Garcia, M. Juliana, Latifi, Neda, Jiang, Yidi, Huszti, Ella, Simmons, Craig A., Keller, Gordon, Laflamme, Michael A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell Line Guinea Pigs Humans Myocytes, Cardiac - metabolism Plastics - metabolism Pluripotent Stem Cells - metabolism
Online-Zugang:	Volltext
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