Integration of intestinal microbiota and metabonomics to elucidate different alleviation impacts of non-saponification and saponification astaxanthin pre-treatment on paracetamol-induced oxidative stress in rats
Intestinal microbiota and metabonomics were integrated to investigate the efficiency of non-saponification or saponification astaxanthin (N-Asta or S-Asta) derived from Penaeus sinensis by-products on alleviating paracetamol (PCM)-induced oxidative stress. Pre-treatment with N-Asta or S-Asta for 14...
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| creator | Song, Ru Xu, Yan Jia, Zhe Liu, Xinyan Zhang, Xiaoxia |
| description | Intestinal microbiota and metabonomics were integrated to investigate the efficiency of non-saponification or saponification astaxanthin (N-Asta or S-Asta) derived from
Penaeus sinensis
by-products on alleviating paracetamol (PCM)-induced oxidative stress. Pre-treatment with N-Asta or S-Asta for 14 days restored the cellular morphology of the intestine and increased glutathione (GSH) levels under PCM overdose in rats. However, S-Asta displayed higher adsorption than that of N-Asta. PCM overdose reduced the richness and diversity of intestinal microbiota in the model group. Comparably, N-Asta or S-Asta pre-treatment increased the Actinobacteria abundance. Increased phyla Bacteroidetes and Verrucomicrobia were only found in the S-Asta-pre-treated group. At the genus level, N-Asta pre-treatment increased
Lactobacillus
and
Parasutterella
abundance, whereas S-Asta pre-treatment elevated
Bacteroidales_S24-7_group_norank
and
Ruminococcaceae_uncultured
. Compared to the control and model groups, remarkable increases of fecal short-chain fatty acids were detected in both N-Asta and S-Asta pre-treatment groups, suggesting the contribution of N-Asta and S-Asta adsorption to SCFA-producing bacteria enrichment. Furthermore, the genera of
Ruminococcaceae_uncultured, Ruminiclostridium_9, Ruminococcaceae_unclassified
and
Ruminococcus_1
showed high correlations with propionic acid, isobutyric acid, butyric acid, isovaleric acid and valeric acid increases in the S-Asta pre-treated group. Seventeen plasma biomarker metabolites in more than 10 metabolic pathways were responsible for the difference between the N-Asta and S-Asta pre-treated groups. Metabolites GSH, retinol, all-
trans
-Retinoic acid and taurine related to antioxidant activities were significantly accumulated in the S-Asta pre-treated group, while increasing taurocholic acid levels associated with the anti-inflammatory activity was found in the N-Asta-pre-treated group. Therefore, N-Asta and S-Asta could have potential applications in counterbalancing intestinal flora and metabolite disturbances by overdose chemical induction.
Saponification Asta (S-Asta) pre-treatment demonstrated stronger alleviation impacts than nonsaponificaiton Asta (N-Asta) against paracetamol (PCM) induced oxidative stress. |
| doi_str_mv | 10.1039/d1fo02972j |
| format | Article |
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Penaeus sinensis
by-products on alleviating paracetamol (PCM)-induced oxidative stress. Pre-treatment with N-Asta or S-Asta for 14 days restored the cellular morphology of the intestine and increased glutathione (GSH) levels under PCM overdose in rats. However, S-Asta displayed higher adsorption than that of N-Asta. PCM overdose reduced the richness and diversity of intestinal microbiota in the model group. Comparably, N-Asta or S-Asta pre-treatment increased the Actinobacteria abundance. Increased phyla Bacteroidetes and Verrucomicrobia were only found in the S-Asta-pre-treated group. At the genus level, N-Asta pre-treatment increased
Lactobacillus
and
Parasutterella
abundance, whereas S-Asta pre-treatment elevated
Bacteroidales_S24-7_group_norank
and
Ruminococcaceae_uncultured
. Compared to the control and model groups, remarkable increases of fecal short-chain fatty acids were detected in both N-Asta and S-Asta pre-treatment groups, suggesting the contribution of N-Asta and S-Asta adsorption to SCFA-producing bacteria enrichment. Furthermore, the genera of
Ruminococcaceae_uncultured, Ruminiclostridium_9, Ruminococcaceae_unclassified
and
Ruminococcus_1
showed high correlations with propionic acid, isobutyric acid, butyric acid, isovaleric acid and valeric acid increases in the S-Asta pre-treated group. Seventeen plasma biomarker metabolites in more than 10 metabolic pathways were responsible for the difference between the N-Asta and S-Asta pre-treated groups. Metabolites GSH, retinol, all-
trans
-Retinoic acid and taurine related to antioxidant activities were significantly accumulated in the S-Asta pre-treated group, while increasing taurocholic acid levels associated with the anti-inflammatory activity was found in the N-Asta-pre-treated group. Therefore, N-Asta and S-Asta could have potential applications in counterbalancing intestinal flora and metabolite disturbances by overdose chemical induction.
Saponification Asta (S-Asta) pre-treatment demonstrated stronger alleviation impacts than nonsaponificaiton Asta (N-Asta) against paracetamol (PCM) induced oxidative stress.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d1fo02972j</identifier><identifier>PMID: 35084415</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Abundance ; Acetaminophen - adverse effects ; Adsorption ; Analgesics ; Animals ; Anti-inflammatory agents ; Antioxidants ; Antioxidants - pharmacology ; Astaxanthin ; Biomarkers ; Butyric acid ; Disease Models, Animal ; Fatty acids ; Flora ; Gastrointestinal Microbiome - drug effects ; Glutathione ; Inflammation ; Intestinal microflora ; Intestine ; Isobutyric acid ; Male ; Metabolic pathways ; Metabolites ; Metabolome - drug effects ; Metabolomics ; Microbiota ; Overdose ; Oxidative stress ; Oxidative Stress - drug effects ; Paracetamol ; Pretreatment ; Propionic acid ; Rats ; Rats, Sprague-Dawley ; Retinoic acid ; Ruminococcaceae ; Taurine ; Taurocholic acid ; Valeric acid ; Vitamin A ; Xanthophylls - pharmacology</subject><ispartof>Food & function, 2022-02, Vol.13 (4), p.186-188</ispartof><rights>Copyright Royal Society of Chemistry 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-44a8e8bbe5fbbead9a9809cf0fa543282037213b7450e8d53990897494e38fb63</citedby><cites>FETCH-LOGICAL-c337t-44a8e8bbe5fbbead9a9809cf0fa543282037213b7450e8d53990897494e38fb63</cites><orcidid>0000-0002-1324-777X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35084415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Ru</creatorcontrib><creatorcontrib>Xu, Yan</creatorcontrib><creatorcontrib>Jia, Zhe</creatorcontrib><creatorcontrib>Liu, Xinyan</creatorcontrib><creatorcontrib>Zhang, Xiaoxia</creatorcontrib><title>Integration of intestinal microbiota and metabonomics to elucidate different alleviation impacts of non-saponification and saponification astaxanthin pre-treatment on paracetamol-induced oxidative stress in rats</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Intestinal microbiota and metabonomics were integrated to investigate the efficiency of non-saponification or saponification astaxanthin (N-Asta or S-Asta) derived from
Penaeus sinensis
by-products on alleviating paracetamol (PCM)-induced oxidative stress. Pre-treatment with N-Asta or S-Asta for 14 days restored the cellular morphology of the intestine and increased glutathione (GSH) levels under PCM overdose in rats. However, S-Asta displayed higher adsorption than that of N-Asta. PCM overdose reduced the richness and diversity of intestinal microbiota in the model group. Comparably, N-Asta or S-Asta pre-treatment increased the Actinobacteria abundance. Increased phyla Bacteroidetes and Verrucomicrobia were only found in the S-Asta-pre-treated group. At the genus level, N-Asta pre-treatment increased
Lactobacillus
and
Parasutterella
abundance, whereas S-Asta pre-treatment elevated
Bacteroidales_S24-7_group_norank
and
Ruminococcaceae_uncultured
. Compared to the control and model groups, remarkable increases of fecal short-chain fatty acids were detected in both N-Asta and S-Asta pre-treatment groups, suggesting the contribution of N-Asta and S-Asta adsorption to SCFA-producing bacteria enrichment. Furthermore, the genera of
Ruminococcaceae_uncultured, Ruminiclostridium_9, Ruminococcaceae_unclassified
and
Ruminococcus_1
showed high correlations with propionic acid, isobutyric acid, butyric acid, isovaleric acid and valeric acid increases in the S-Asta pre-treated group. Seventeen plasma biomarker metabolites in more than 10 metabolic pathways were responsible for the difference between the N-Asta and S-Asta pre-treated groups. Metabolites GSH, retinol, all-
trans
-Retinoic acid and taurine related to antioxidant activities were significantly accumulated in the S-Asta pre-treated group, while increasing taurocholic acid levels associated with the anti-inflammatory activity was found in the N-Asta-pre-treated group. Therefore, N-Asta and S-Asta could have potential applications in counterbalancing intestinal flora and metabolite disturbances by overdose chemical induction.
Saponification Asta (S-Asta) pre-treatment demonstrated stronger alleviation impacts than nonsaponificaiton Asta (N-Asta) against paracetamol (PCM) induced oxidative stress.</description><subject>Abundance</subject><subject>Acetaminophen - adverse effects</subject><subject>Adsorption</subject><subject>Analgesics</subject><subject>Animals</subject><subject>Anti-inflammatory agents</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Astaxanthin</subject><subject>Biomarkers</subject><subject>Butyric acid</subject><subject>Disease Models, Animal</subject><subject>Fatty acids</subject><subject>Flora</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Glutathione</subject><subject>Inflammation</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Isobutyric acid</subject><subject>Male</subject><subject>Metabolic pathways</subject><subject>Metabolites</subject><subject>Metabolome - drug effects</subject><subject>Metabolomics</subject><subject>Microbiota</subject><subject>Overdose</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Paracetamol</subject><subject>Pretreatment</subject><subject>Propionic acid</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Retinoic acid</subject><subject>Ruminococcaceae</subject><subject>Taurine</subject><subject>Taurocholic acid</subject><subject>Valeric acid</subject><subject>Vitamin A</subject><subject>Xanthophylls - pharmacology</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkl1r1zAUxoMobszdeK8EvBGhmiZpm1zKdDoZ7EbBu3Kanmj-tElN0jE_p1_I1G4Tlou8nPPjyclzQsjzmr2tmdDvxtoGxnXHD4_IMWeSV23Dvj--20vdHpHTlA6sDKG10uopORINU1LWzTH5c-Ez_oiQXfA0WOrKMWXnYaKzMzEMLmSg4Ec6Y4Yh-FDCieZAcVqNGyEjHZ21GNFnCtOE124Xc_MCJqdN1AdfJViCd9aZPbspPgylDDfg80_n6RKxyhEhz5tsSS4QwZQK5jBVzo-rwZGGm-1-d400FTalUjwtL0nPyBMLU8LT2_WEfDv_-PXsc3V59eni7P1lZYTociUlKFTDgI0tE4watGLaWGahkYIrzkTHazF0smGoxqa4x5TupJYolB1acUJe77pLDL_WYls_u2RwmsBjWFPPWy4E143uCvrqAXoIaywub5Rgmsu2E4V6s1PF-JQi2n6Jbob4u69Zv3W7_1CfX_3r9pcCv7yVXIcZx3v0rrcFeLEDMZn77P_vIv4Chxm1PQ</recordid><startdate>20220221</startdate><enddate>20220221</enddate><creator>Song, Ru</creator><creator>Xu, Yan</creator><creator>Jia, Zhe</creator><creator>Liu, Xinyan</creator><creator>Zhang, Xiaoxia</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1324-777X</orcidid></search><sort><creationdate>20220221</creationdate><title>Integration of intestinal microbiota and metabonomics to elucidate different alleviation impacts of non-saponification and saponification astaxanthin pre-treatment on paracetamol-induced oxidative stress in rats</title><author>Song, Ru ; Xu, Yan ; Jia, Zhe ; Liu, Xinyan ; Zhang, Xiaoxia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-44a8e8bbe5fbbead9a9809cf0fa543282037213b7450e8d53990897494e38fb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abundance</topic><topic>Acetaminophen - adverse effects</topic><topic>Adsorption</topic><topic>Analgesics</topic><topic>Animals</topic><topic>Anti-inflammatory agents</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Astaxanthin</topic><topic>Biomarkers</topic><topic>Butyric acid</topic><topic>Disease Models, Animal</topic><topic>Fatty acids</topic><topic>Flora</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Glutathione</topic><topic>Inflammation</topic><topic>Intestinal microflora</topic><topic>Intestine</topic><topic>Isobutyric acid</topic><topic>Male</topic><topic>Metabolic pathways</topic><topic>Metabolites</topic><topic>Metabolome - drug effects</topic><topic>Metabolomics</topic><topic>Microbiota</topic><topic>Overdose</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Paracetamol</topic><topic>Pretreatment</topic><topic>Propionic acid</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Retinoic acid</topic><topic>Ruminococcaceae</topic><topic>Taurine</topic><topic>Taurocholic acid</topic><topic>Valeric acid</topic><topic>Vitamin A</topic><topic>Xanthophylls - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Ru</creatorcontrib><creatorcontrib>Xu, Yan</creatorcontrib><creatorcontrib>Jia, Zhe</creatorcontrib><creatorcontrib>Liu, Xinyan</creatorcontrib><creatorcontrib>Zhang, Xiaoxia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Ru</au><au>Xu, Yan</au><au>Jia, Zhe</au><au>Liu, Xinyan</au><au>Zhang, Xiaoxia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Integration of intestinal microbiota and metabonomics to elucidate different alleviation impacts of non-saponification and saponification astaxanthin pre-treatment on paracetamol-induced oxidative stress in rats</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2022-02-21</date><risdate>2022</risdate><volume>13</volume><issue>4</issue><spage>186</spage><epage>188</epage><pages>186-188</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Intestinal microbiota and metabonomics were integrated to investigate the efficiency of non-saponification or saponification astaxanthin (N-Asta or S-Asta) derived from
Penaeus sinensis
by-products on alleviating paracetamol (PCM)-induced oxidative stress. Pre-treatment with N-Asta or S-Asta for 14 days restored the cellular morphology of the intestine and increased glutathione (GSH) levels under PCM overdose in rats. However, S-Asta displayed higher adsorption than that of N-Asta. PCM overdose reduced the richness and diversity of intestinal microbiota in the model group. Comparably, N-Asta or S-Asta pre-treatment increased the Actinobacteria abundance. Increased phyla Bacteroidetes and Verrucomicrobia were only found in the S-Asta-pre-treated group. At the genus level, N-Asta pre-treatment increased
Lactobacillus
and
Parasutterella
abundance, whereas S-Asta pre-treatment elevated
Bacteroidales_S24-7_group_norank
and
Ruminococcaceae_uncultured
. Compared to the control and model groups, remarkable increases of fecal short-chain fatty acids were detected in both N-Asta and S-Asta pre-treatment groups, suggesting the contribution of N-Asta and S-Asta adsorption to SCFA-producing bacteria enrichment. Furthermore, the genera of
Ruminococcaceae_uncultured, Ruminiclostridium_9, Ruminococcaceae_unclassified
and
Ruminococcus_1
showed high correlations with propionic acid, isobutyric acid, butyric acid, isovaleric acid and valeric acid increases in the S-Asta pre-treated group. Seventeen plasma biomarker metabolites in more than 10 metabolic pathways were responsible for the difference between the N-Asta and S-Asta pre-treated groups. Metabolites GSH, retinol, all-
trans
-Retinoic acid and taurine related to antioxidant activities were significantly accumulated in the S-Asta pre-treated group, while increasing taurocholic acid levels associated with the anti-inflammatory activity was found in the N-Asta-pre-treated group. Therefore, N-Asta and S-Asta could have potential applications in counterbalancing intestinal flora and metabolite disturbances by overdose chemical induction.
Saponification Asta (S-Asta) pre-treatment demonstrated stronger alleviation impacts than nonsaponificaiton Asta (N-Asta) against paracetamol (PCM) induced oxidative stress.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35084415</pmid><doi>10.1039/d1fo02972j</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0002-1324-777X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2042-6496 |
| ispartof | Food & function, 2022-02, Vol.13 (4), p.186-188 |
| issn | 2042-6496 2042-650X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2623329597 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Abundance Acetaminophen - adverse effects Adsorption Analgesics Animals Anti-inflammatory agents Antioxidants Antioxidants - pharmacology Astaxanthin Biomarkers Butyric acid Disease Models, Animal Fatty acids Flora Gastrointestinal Microbiome - drug effects Glutathione Inflammation Intestinal microflora Intestine Isobutyric acid Male Metabolic pathways Metabolites Metabolome - drug effects Metabolomics Microbiota Overdose Oxidative stress Oxidative Stress - drug effects Paracetamol Pretreatment Propionic acid Rats Rats, Sprague-Dawley Retinoic acid Ruminococcaceae Taurine Taurocholic acid Valeric acid Vitamin A Xanthophylls - pharmacology |
| title | Integration of intestinal microbiota and metabonomics to elucidate different alleviation impacts of non-saponification and saponification astaxanthin pre-treatment on paracetamol-induced oxidative stress in rats |
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