Comparative analysis of in vitro dynamics and mechanisms of ceftolozane/tazobactam and imipenem/relebactam resistance development in Pseudomonas aeruginosa XDR high-risk clones

Abstract Objectives To analyse the dynamics and mechanisms of stepwise resistance development to ceftolozane/tazobactam and imipenem/relebactam in XDR Pseudomonas aeruginosa clinical strains. Methods XDR clinical isolates belonging to ST111 (main resistance mechanisms: oprD−, dacB−, CARB-2), ST175 (...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2022-03, Vol.77 (4), p.957-968
Hauptverfasser:	Gomis-Font, María A., Cabot, Gabriel, López-Argüello, Silvia, Zamorano, Laura, Juan, Carlos, Moyá, Bartolomé, Oliver, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Azabicyclo Compounds Cephalosporins - pharmacology Cephalosporins - therapeutic use Clone Cells Drug Resistance, Multiple, Bacterial - genetics Humans Imipenem - pharmacology Imipenem - therapeutic use Microbial Sensitivity Tests Pseudomonas aeruginosa - genetics Pseudomonas Infections - drug therapy Tazobactam - pharmacology Tazobactam - therapeutic use
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