Incidence of pancreatic cancer during long-term follow-up in patients with incidental pancreatic cysts smaller than 2 cm

Purpose To assess the long-term malignancy risk of incidental small pancreatic cysts. Materials and methods In this HIPAA-compliant, IRB-approved, retrospective, multi-institutional study, the long-term incidence of pancreatic cancer was compared between patients with and without small pancreatic cy...

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Veröffentlicht in:European radiology 2022-05, Vol.32 (5), p.3369-3376
Hauptverfasser: Nakhaei, Masoud, Bligh, Mathew, Chernyak, Victoria, Bezuidenhout, Abraham F., Brook, Alexander, Brook, Olga R.
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container_title European radiology
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creator Nakhaei, Masoud
Bligh, Mathew
Chernyak, Victoria
Bezuidenhout, Abraham F.
Brook, Alexander
Brook, Olga R.
description Purpose To assess the long-term malignancy risk of incidental small pancreatic cysts. Materials and methods In this HIPAA-compliant, IRB-approved, retrospective, multi-institutional study, the long-term incidence of pancreatic cancer was compared between patients with and without small pancreatic cysts. Patients with incidental pancreatic cysts ≥ 0.5 and 
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Materials and methods In this HIPAA-compliant, IRB-approved, retrospective, multi-institutional study, the long-term incidence of pancreatic cancer was compared between patients with and without small pancreatic cysts. Patients with incidental pancreatic cysts ≥ 0.5 and &lt; 2.0 cm in maximal diameter, detected on MRI performed between 1999 and 2011, represented the “small pancreatic cyst” group. Patients that underwent MRI between 2005 and 2011 and had no reported pancreatic cysts represented the comparison “no cyst” group. Results The “small pancreatic cyst” group included 267 patients, ages 63.4 ± 11.8 years, 166/267 (62%) women with a mean follow-up of 8.6 ± 4.3 years, median 9.2 years; the “no cyst” group included 1,459 patients, ages 64.6 ± 12 years, 794/1,459 (54%) women with a mean follow-up of 7.0 ± 4.2 years, median 7.8 ( p values 0.12, 0.02, &lt; 0.001, respectively). Two/267 (0.7%) patients developed pancreatic cancer at a separate location from the known cyst in the “small pancreatic cyst” group, with a cancer rate of 0.9 (95% CI 0.1–3.1) cases per 1,000 patient-years. In the “no cyst” cohort, 18/1,459 (1.2%) patients developed pancreatic cancer, with a cancer rate of 1.8 (95% CI 1.2–3.1) cases per 1,000 patient-years ( p  = 0.6). The all-cause mortality was similar in both groups: 57/267 (21%) vs. 384/1,459 (26%) ( p  = 0.09). Conclusion The long-term risk of pancreatic malignancy in asymptomatic patients with incidental pancreatic cysts less than 2 cm is 0.9 cases per 1,000 patient-years of follow-up, similar to those without pancreatic cysts. These very few pancreatic cancers developed at a separate location from the known cyst. Key Points • After a median of 9.2 years of follow-up, the risk of pancreatic malignancy in patients with an asymptomatic small pancreatic cyst was 0.9 cases per 1,000 patient-years of follow-up, similar to those without pancreatic cysts. • Very few pancreatic cancer cases developed in the location separate from the known pancreatic cyst.</description><identifier>ISSN: 1432-1084</identifier><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-021-08428-1</identifier><identifier>PMID: 35013764</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Asymptomatic ; Cancer ; Cysts ; Diagnostic Radiology ; Female ; Follow-Up Studies ; Hepatobiliary-Pancreas ; Humans ; Imaging ; Incidence ; Incidental Findings ; Internal Medicine ; Interventional Radiology ; Magnetic resonance imaging ; Male ; Malignancy ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Neuroradiology ; Pancreatic cancer ; Pancreatic Cyst - diagnostic imaging ; Pancreatic Cyst - epidemiology ; Pancreatic Cyst - pathology ; Pancreatic Neoplasms - diagnostic imaging ; Pancreatic Neoplasms - epidemiology ; Pancreatic Neoplasms - pathology ; Patients ; Radiology ; Retrospective Studies ; Ultrasound</subject><ispartof>European radiology, 2022-05, Vol.32 (5), p.3369-3376</ispartof><rights>The Author(s), under exclusive licence to European Society of Radiology 2021</rights><rights>2021. The Author(s), under exclusive licence to European Society of Radiology.</rights><rights>The Author(s), under exclusive licence to European Society of Radiology 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-c9cb031f41c1ebe75838f76c3108424283ae3b34ad3013ab65de224f64b310673</citedby><cites>FETCH-LOGICAL-c305t-c9cb031f41c1ebe75838f76c3108424283ae3b34ad3013ab65de224f64b310673</cites><orcidid>0000-0002-7074-8909</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-021-08428-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-021-08428-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35013764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakhaei, Masoud</creatorcontrib><creatorcontrib>Bligh, Mathew</creatorcontrib><creatorcontrib>Chernyak, Victoria</creatorcontrib><creatorcontrib>Bezuidenhout, Abraham F.</creatorcontrib><creatorcontrib>Brook, Alexander</creatorcontrib><creatorcontrib>Brook, Olga R.</creatorcontrib><title>Incidence of pancreatic cancer during long-term follow-up in patients with incidental pancreatic cysts smaller than 2 cm</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Purpose To assess the long-term malignancy risk of incidental small pancreatic cysts. Materials and methods In this HIPAA-compliant, IRB-approved, retrospective, multi-institutional study, the long-term incidence of pancreatic cancer was compared between patients with and without small pancreatic cysts. Patients with incidental pancreatic cysts ≥ 0.5 and &lt; 2.0 cm in maximal diameter, detected on MRI performed between 1999 and 2011, represented the “small pancreatic cyst” group. Patients that underwent MRI between 2005 and 2011 and had no reported pancreatic cysts represented the comparison “no cyst” group. Results The “small pancreatic cyst” group included 267 patients, ages 63.4 ± 11.8 years, 166/267 (62%) women with a mean follow-up of 8.6 ± 4.3 years, median 9.2 years; the “no cyst” group included 1,459 patients, ages 64.6 ± 12 years, 794/1,459 (54%) women with a mean follow-up of 7.0 ± 4.2 years, median 7.8 ( p values 0.12, 0.02, &lt; 0.001, respectively). Two/267 (0.7%) patients developed pancreatic cancer at a separate location from the known cyst in the “small pancreatic cyst” group, with a cancer rate of 0.9 (95% CI 0.1–3.1) cases per 1,000 patient-years. In the “no cyst” cohort, 18/1,459 (1.2%) patients developed pancreatic cancer, with a cancer rate of 1.8 (95% CI 1.2–3.1) cases per 1,000 patient-years ( p  = 0.6). The all-cause mortality was similar in both groups: 57/267 (21%) vs. 384/1,459 (26%) ( p  = 0.09). Conclusion The long-term risk of pancreatic malignancy in asymptomatic patients with incidental pancreatic cysts less than 2 cm is 0.9 cases per 1,000 patient-years of follow-up, similar to those without pancreatic cysts. These very few pancreatic cancers developed at a separate location from the known cyst. Key Points • After a median of 9.2 years of follow-up, the risk of pancreatic malignancy in patients with an asymptomatic small pancreatic cyst was 0.9 cases per 1,000 patient-years of follow-up, similar to those without pancreatic cysts. • Very few pancreatic cancer cases developed in the location separate from the known pancreatic cyst.</description><subject>Aged</subject><subject>Asymptomatic</subject><subject>Cancer</subject><subject>Cysts</subject><subject>Diagnostic Radiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hepatobiliary-Pancreas</subject><subject>Humans</subject><subject>Imaging</subject><subject>Incidence</subject><subject>Incidental Findings</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Neuroradiology</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Cyst - diagnostic imaging</subject><subject>Pancreatic Cyst - epidemiology</subject><subject>Pancreatic Cyst - pathology</subject><subject>Pancreatic Neoplasms - diagnostic imaging</subject><subject>Pancreatic Neoplasms - epidemiology</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Patients</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Ultrasound</subject><issn>1432-1084</issn><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1OHSEUx0nTplevfQEXhqQbNyhwmI-7NKZ-JCZu7JowzBmdG4aZAhNz36bP0icr16vWunDFgfzODw5_Qg4FPxGcV6eRcwDOuBSM10rWTHwie0KBZCLvP7-pF2Q_xjXnfCVU9ZUsoOACqlLtkc21t32L3iIdOzoZbwOa1Ftqc4mBtnPo_T11o79nCcNAu9G58ZHNE-195lOPPkX62KeHfPCkSsb9J9rEDMTBOJd96cF4Kv_8tsMB-dIZF_Hb87okPy9-3J1fsZvby-vzsxtmgReJ2ZVtOIhOCSuwwaqooe6q0sJ2LpmnBoPQgDIt5JlMUxYtSqm6UjUZKStYkuOddwrjrxlj0kMfLTpnPI5z1LKUAFJVvMjo93foepyDz6_LVKFqWUhVZkruKBvGGAN2egr9YMJGC663wehdMDoHo5-C0SI3HT2r52bA9rXlJYkMwA6I0_bHMfy7-wPtX9fbmUY</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Nakhaei, Masoud</creator><creator>Bligh, Mathew</creator><creator>Chernyak, Victoria</creator><creator>Bezuidenhout, Abraham F.</creator><creator>Brook, Alexander</creator><creator>Brook, Olga R.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7074-8909</orcidid></search><sort><creationdate>202205</creationdate><title>Incidence of pancreatic cancer during long-term follow-up in patients with incidental pancreatic cysts smaller than 2 cm</title><author>Nakhaei, Masoud ; 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Materials and methods In this HIPAA-compliant, IRB-approved, retrospective, multi-institutional study, the long-term incidence of pancreatic cancer was compared between patients with and without small pancreatic cysts. Patients with incidental pancreatic cysts ≥ 0.5 and &lt; 2.0 cm in maximal diameter, detected on MRI performed between 1999 and 2011, represented the “small pancreatic cyst” group. Patients that underwent MRI between 2005 and 2011 and had no reported pancreatic cysts represented the comparison “no cyst” group. Results The “small pancreatic cyst” group included 267 patients, ages 63.4 ± 11.8 years, 166/267 (62%) women with a mean follow-up of 8.6 ± 4.3 years, median 9.2 years; the “no cyst” group included 1,459 patients, ages 64.6 ± 12 years, 794/1,459 (54%) women with a mean follow-up of 7.0 ± 4.2 years, median 7.8 ( p values 0.12, 0.02, &lt; 0.001, respectively). Two/267 (0.7%) patients developed pancreatic cancer at a separate location from the known cyst in the “small pancreatic cyst” group, with a cancer rate of 0.9 (95% CI 0.1–3.1) cases per 1,000 patient-years. In the “no cyst” cohort, 18/1,459 (1.2%) patients developed pancreatic cancer, with a cancer rate of 1.8 (95% CI 1.2–3.1) cases per 1,000 patient-years ( p  = 0.6). The all-cause mortality was similar in both groups: 57/267 (21%) vs. 384/1,459 (26%) ( p  = 0.09). Conclusion The long-term risk of pancreatic malignancy in asymptomatic patients with incidental pancreatic cysts less than 2 cm is 0.9 cases per 1,000 patient-years of follow-up, similar to those without pancreatic cysts. These very few pancreatic cancers developed at a separate location from the known cyst. Key Points • After a median of 9.2 years of follow-up, the risk of pancreatic malignancy in patients with an asymptomatic small pancreatic cyst was 0.9 cases per 1,000 patient-years of follow-up, similar to those without pancreatic cysts. • Very few pancreatic cancer cases developed in the location separate from the known pancreatic cyst.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35013764</pmid><doi>10.1007/s00330-021-08428-1</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7074-8909</orcidid></addata></record>
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subjects Aged
Asymptomatic
Cancer
Cysts
Diagnostic Radiology
Female
Follow-Up Studies
Hepatobiliary-Pancreas
Humans
Imaging
Incidence
Incidental Findings
Internal Medicine
Interventional Radiology
Magnetic resonance imaging
Male
Malignancy
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Pancreatic cancer
Pancreatic Cyst - diagnostic imaging
Pancreatic Cyst - epidemiology
Pancreatic Cyst - pathology
Pancreatic Neoplasms - diagnostic imaging
Pancreatic Neoplasms - epidemiology
Pancreatic Neoplasms - pathology
Patients
Radiology
Retrospective Studies
Ultrasound
title Incidence of pancreatic cancer during long-term follow-up in patients with incidental pancreatic cysts smaller than 2 cm
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