Preclinical evaluation of [99mTc]Tc-labeled anti-EpCAM nanobody for EpCAM receptor expression imaging by immuno-SPECT/CT

Purpose Overexpression of epithelial cell adhesion molecule (EpCAM) plays essential roles in tumorigenesis and tumor progression in almost all epithelium-derived cancer. Monitoring EpCAM expression in tumors can be used for the diagnosis, staging, and prognosis of cancer patients, as well as guiding...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2022-05, Vol.49 (6), p.1810-1821
Hauptverfasser:	Liu, Tianyu, Wu, Yue, Shi, Linqing, Li, Liqiang, Hu, Biao, Wang, Yanpu, Gao, Hannan, Yu, Xiaolu, Zhang, Xin, Zhao, Huiyun, Wan, Yakun, Jia, Bing, Wang, Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Cardiology Cell adhesion Cell adhesion molecules Cell Line, Tumor Computed tomography Epithelial Cell Adhesion Molecule Epithelial cells Epithelium Humans Imaging In vivo methods and tests Kidneys Lymph nodes Medical imaging Medicine Medicine & Public Health Metastases Nanobodies Neoplasms Nuclear Medicine Oncology Organs Original Article Orthopedics Preclinical Imaging Radioactive tracers Radiology Single photon emission computed tomography Single Photon Emission Computed Tomography Computed Tomography Technetium Technetium isotopes Tomography, Emission-Computed, Single-Photon - methods Tumorigenesis Tumors
Online-Zugang:	Volltext
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