Catheter Ablation Energy Sources and Myocardial Injury and Coagulation Biomarkers During Uninterrupted Periprocedural Edoxaban Use ― A Subanalysis of KYU-RABLE
Background:The effects of catheter ablation (CA) energy sources on myocardial injury and coagulation biomarkers among Japanese non-valvular atrial fibrillation patients receiving uninterrupted periprocedural edoxaban are unclear. This KYU-RABLE exploratory subanalysis compared the effects of CA usin...
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| Veröffentlicht in: | Circulation Journal 2022/01/25, Vol.86(2), pp.280-286 |
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| creator | Shinohara, Tetsuji Takahashi, Naohiko Mukai, Yasushi Kimura, Tetsuya Yamaguchi, Keita Takita, Atsushi Origasa, Hideki Okumura, Ken Investigators, for the KYU-RABLE |
| description | Background:The effects of catheter ablation (CA) energy sources on myocardial injury and coagulation biomarkers among Japanese non-valvular atrial fibrillation patients receiving uninterrupted periprocedural edoxaban are unclear. This KYU-RABLE exploratory subanalysis compared the effects of CA using radiofrequency energy vs. cryoballoon on: (1) myocardial injury; and (2) plasma edoxaban and coagulation biomarker concentrations measured before and after CA.Methods and Results:Plasma creatine kinase (CK), edoxaban, D-dimer, and prothrombin fragment 1+2 (F1+2) concentrations within 1 h before CA were compared with concentrations the day after. All biomarkers increased after CA, regardless of the energy source, but especially with cryoballoon. Significantly higher increases in CK concentrations from before to the day after CA were seen with cryoballoon compared with radiofrequency energy (P |
| doi_str_mv | 10.1253/circj.CJ-21-0247 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2623055951</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2623055951</sourcerecordid><originalsourceid>FETCH-LOGICAL-c622t-2480839f32889cba63693ff6ddac5819dddecb81f0ff8f45bd9ccbd01f16abef3</originalsourceid><addsrcrecordid>eNpFkctu1DAUhiNERUthzwp5ySbFlyQTL6dhCm0HgSizYGU59vHUQ8Ye7Fgiu3kJnoA3gxchc6Hd2NbR93868p9lrwi-ILRkb5UNanXR3OSU5JgWkyfZGWHFJC9qip_u31XO64KdZs9jXGFMOS75s-yUFXRS8snkLPvdyP4eegho2nayt96hmYOwHNCdT0FBRNJp9HHwSgZtZYeu3SqFYT9tvFymY-jS-rUM3yFE9C4F65Zo4awbvSFtetDoMwS7CV6BTmG0zLT_KVvp0CLC3-32z_YXmqK7NE5kN0QbkTfo9tsi_zK9nM9eZCdGdhFeHu_zbHE1-9p8yOef3l8303muKkr7nBY1rhk3jNY1V62sWMWZMZXWUpU14VprUG1NDDamNkXZaq5UqzExpJItGHaevTl4x0V_JIi9WNuooOukA5-ioBVluCx5SUYUH1AVfIwBjNgEO37AIAgWu2rEvhrR3AhKxK6aMfL6aE_tGvRD4H8XI3B1AFaxl0t4AGTorergaKwrQXfHo_kRuJdBgGP_AB6SqfU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2623055951</pqid></control><display><type>article</type><title>Catheter Ablation Energy Sources and Myocardial Injury and Coagulation Biomarkers During Uninterrupted Periprocedural Edoxaban Use ― A Subanalysis of KYU-RABLE</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Shinohara, Tetsuji ; Takahashi, Naohiko ; Mukai, Yasushi ; Kimura, Tetsuya ; Yamaguchi, Keita ; Takita, Atsushi ; Origasa, Hideki ; Okumura, Ken ; Investigators, for the KYU-RABLE</creator><creatorcontrib>Shinohara, Tetsuji ; Takahashi, Naohiko ; Mukai, Yasushi ; Kimura, Tetsuya ; Yamaguchi, Keita ; Takita, Atsushi ; Origasa, Hideki ; Okumura, Ken ; Investigators, for the KYU-RABLE ; KYU-RABLE Investigators ; for the KYU-RABLE Investigators</creatorcontrib><description>Background:The effects of catheter ablation (CA) energy sources on myocardial injury and coagulation biomarkers among Japanese non-valvular atrial fibrillation patients receiving uninterrupted periprocedural edoxaban are unclear. This KYU-RABLE exploratory subanalysis compared the effects of CA using radiofrequency energy vs. cryoballoon on: (1) myocardial injury; and (2) plasma edoxaban and coagulation biomarker concentrations measured before and after CA.Methods and Results:Plasma creatine kinase (CK), edoxaban, D-dimer, and prothrombin fragment 1+2 (F1+2) concentrations within 1 h before CA were compared with concentrations the day after. All biomarkers increased after CA, regardless of the energy source, but especially with cryoballoon. Significantly higher increases in CK concentrations from before to the day after CA were seen with cryoballoon compared with radiofrequency energy (P<0.0001). Edoxaban concentrations were similar in both groups. Concentrations of D-dimer and F1+2 increased in both groups, but were significantly higher in the cryoballoon group (P<0.0001 and P=0.006, respectively). There were no significant between-group differences in the incidence of thrombotic or bleeding events.Conclusions:Uninterrupted edoxaban concentrations were similar in both groups. Both myocardial injury and coagulation biomarkers increased after CA, especially with cryoballoon, but there was no difference in the incidence of thrombotic or bleeding events. These findings suggest the efficacy of uninterrupted edoxaban, regardless of the CA energy source. Periprocedural anticoagulation, particularly with cryoballoon, should be undertaken with care.</description><identifier>ISSN: 1346-9843</identifier><identifier>ISSN: 1347-4820</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-21-0247</identifier><identifier>PMID: 34275977</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Anticoagulants ; Atrial Fibrillation - surgery ; Biomarkers ; Catheter ablation ; Catheter Ablation - adverse effects ; Catheter Ablation - methods ; Cryoballoon ; Heart Injuries ; Hemorrhage ; Humans ; Non-valvular atrial fibrillation ; Pyridines ; Thiazoles ; Treatment Outcome</subject><ispartof>Circulation Journal, 2022/01/25, Vol.86(2), pp.280-286</ispartof><rights>2022, THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c622t-2480839f32889cba63693ff6ddac5819dddecb81f0ff8f45bd9ccbd01f16abef3</citedby><cites>FETCH-LOGICAL-c622t-2480839f32889cba63693ff6ddac5819dddecb81f0ff8f45bd9ccbd01f16abef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34275977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shinohara, Tetsuji</creatorcontrib><creatorcontrib>Takahashi, Naohiko</creatorcontrib><creatorcontrib>Mukai, Yasushi</creatorcontrib><creatorcontrib>Kimura, Tetsuya</creatorcontrib><creatorcontrib>Yamaguchi, Keita</creatorcontrib><creatorcontrib>Takita, Atsushi</creatorcontrib><creatorcontrib>Origasa, Hideki</creatorcontrib><creatorcontrib>Okumura, Ken</creatorcontrib><creatorcontrib>Investigators, for the KYU-RABLE</creatorcontrib><creatorcontrib>KYU-RABLE Investigators</creatorcontrib><creatorcontrib>for the KYU-RABLE Investigators</creatorcontrib><title>Catheter Ablation Energy Sources and Myocardial Injury and Coagulation Biomarkers During Uninterrupted Periprocedural Edoxaban Use ― A Subanalysis of KYU-RABLE</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background:The effects of catheter ablation (CA) energy sources on myocardial injury and coagulation biomarkers among Japanese non-valvular atrial fibrillation patients receiving uninterrupted periprocedural edoxaban are unclear. This KYU-RABLE exploratory subanalysis compared the effects of CA using radiofrequency energy vs. cryoballoon on: (1) myocardial injury; and (2) plasma edoxaban and coagulation biomarker concentrations measured before and after CA.Methods and Results:Plasma creatine kinase (CK), edoxaban, D-dimer, and prothrombin fragment 1+2 (F1+2) concentrations within 1 h before CA were compared with concentrations the day after. All biomarkers increased after CA, regardless of the energy source, but especially with cryoballoon. Significantly higher increases in CK concentrations from before to the day after CA were seen with cryoballoon compared with radiofrequency energy (P<0.0001). Edoxaban concentrations were similar in both groups. Concentrations of D-dimer and F1+2 increased in both groups, but were significantly higher in the cryoballoon group (P<0.0001 and P=0.006, respectively). There were no significant between-group differences in the incidence of thrombotic or bleeding events.Conclusions:Uninterrupted edoxaban concentrations were similar in both groups. Both myocardial injury and coagulation biomarkers increased after CA, especially with cryoballoon, but there was no difference in the incidence of thrombotic or bleeding events. These findings suggest the efficacy of uninterrupted edoxaban, regardless of the CA energy source. Periprocedural anticoagulation, particularly with cryoballoon, should be undertaken with care.</description><subject>Anticoagulants</subject><subject>Atrial Fibrillation - surgery</subject><subject>Biomarkers</subject><subject>Catheter ablation</subject><subject>Catheter Ablation - adverse effects</subject><subject>Catheter Ablation - methods</subject><subject>Cryoballoon</subject><subject>Heart Injuries</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Non-valvular atrial fibrillation</subject><subject>Pyridines</subject><subject>Thiazoles</subject><subject>Treatment Outcome</subject><issn>1346-9843</issn><issn>1347-4820</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkctu1DAUhiNERUthzwp5ySbFlyQTL6dhCm0HgSizYGU59vHUQ8Ye7Fgiu3kJnoA3gxchc6Hd2NbR93868p9lrwi-ILRkb5UNanXR3OSU5JgWkyfZGWHFJC9qip_u31XO64KdZs9jXGFMOS75s-yUFXRS8snkLPvdyP4eegho2nayt96hmYOwHNCdT0FBRNJp9HHwSgZtZYeu3SqFYT9tvFymY-jS-rUM3yFE9C4F65Zo4awbvSFtetDoMwS7CV6BTmG0zLT_KVvp0CLC3-32z_YXmqK7NE5kN0QbkTfo9tsi_zK9nM9eZCdGdhFeHu_zbHE1-9p8yOef3l8303muKkr7nBY1rhk3jNY1V62sWMWZMZXWUpU14VprUG1NDDamNkXZaq5UqzExpJItGHaevTl4x0V_JIi9WNuooOukA5-ioBVluCx5SUYUH1AVfIwBjNgEO37AIAgWu2rEvhrR3AhKxK6aMfL6aE_tGvRD4H8XI3B1AFaxl0t4AGTorergaKwrQXfHo_kRuJdBgGP_AB6SqfU</recordid><startdate>20220125</startdate><enddate>20220125</enddate><creator>Shinohara, Tetsuji</creator><creator>Takahashi, Naohiko</creator><creator>Mukai, Yasushi</creator><creator>Kimura, Tetsuya</creator><creator>Yamaguchi, Keita</creator><creator>Takita, Atsushi</creator><creator>Origasa, Hideki</creator><creator>Okumura, Ken</creator><creator>Investigators, for the KYU-RABLE</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220125</creationdate><title>Catheter Ablation Energy Sources and Myocardial Injury and Coagulation Biomarkers During Uninterrupted Periprocedural Edoxaban Use ― A Subanalysis of KYU-RABLE</title><author>Shinohara, Tetsuji ; Takahashi, Naohiko ; Mukai, Yasushi ; Kimura, Tetsuya ; Yamaguchi, Keita ; Takita, Atsushi ; Origasa, Hideki ; Okumura, Ken ; Investigators, for the KYU-RABLE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c622t-2480839f32889cba63693ff6ddac5819dddecb81f0ff8f45bd9ccbd01f16abef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anticoagulants</topic><topic>Atrial Fibrillation - surgery</topic><topic>Biomarkers</topic><topic>Catheter ablation</topic><topic>Catheter Ablation - adverse effects</topic><topic>Catheter Ablation - methods</topic><topic>Cryoballoon</topic><topic>Heart Injuries</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Non-valvular atrial fibrillation</topic><topic>Pyridines</topic><topic>Thiazoles</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shinohara, Tetsuji</creatorcontrib><creatorcontrib>Takahashi, Naohiko</creatorcontrib><creatorcontrib>Mukai, Yasushi</creatorcontrib><creatorcontrib>Kimura, Tetsuya</creatorcontrib><creatorcontrib>Yamaguchi, Keita</creatorcontrib><creatorcontrib>Takita, Atsushi</creatorcontrib><creatorcontrib>Origasa, Hideki</creatorcontrib><creatorcontrib>Okumura, Ken</creatorcontrib><creatorcontrib>Investigators, for the KYU-RABLE</creatorcontrib><creatorcontrib>KYU-RABLE Investigators</creatorcontrib><creatorcontrib>for the KYU-RABLE Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shinohara, Tetsuji</au><au>Takahashi, Naohiko</au><au>Mukai, Yasushi</au><au>Kimura, Tetsuya</au><au>Yamaguchi, Keita</au><au>Takita, Atsushi</au><au>Origasa, Hideki</au><au>Okumura, Ken</au><au>Investigators, for the KYU-RABLE</au><aucorp>KYU-RABLE Investigators</aucorp><aucorp>for the KYU-RABLE Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Catheter Ablation Energy Sources and Myocardial Injury and Coagulation Biomarkers During Uninterrupted Periprocedural Edoxaban Use ― A Subanalysis of KYU-RABLE</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2022-01-25</date><risdate>2022</risdate><volume>86</volume><issue>2</issue><spage>280</spage><epage>286</epage><pages>280-286</pages><artnum>CJ-21-0247</artnum><issn>1346-9843</issn><issn>1347-4820</issn><eissn>1347-4820</eissn><abstract>Background:The effects of catheter ablation (CA) energy sources on myocardial injury and coagulation biomarkers among Japanese non-valvular atrial fibrillation patients receiving uninterrupted periprocedural edoxaban are unclear. This KYU-RABLE exploratory subanalysis compared the effects of CA using radiofrequency energy vs. cryoballoon on: (1) myocardial injury; and (2) plasma edoxaban and coagulation biomarker concentrations measured before and after CA.Methods and Results:Plasma creatine kinase (CK), edoxaban, D-dimer, and prothrombin fragment 1+2 (F1+2) concentrations within 1 h before CA were compared with concentrations the day after. All biomarkers increased after CA, regardless of the energy source, but especially with cryoballoon. Significantly higher increases in CK concentrations from before to the day after CA were seen with cryoballoon compared with radiofrequency energy (P<0.0001). Edoxaban concentrations were similar in both groups. Concentrations of D-dimer and F1+2 increased in both groups, but were significantly higher in the cryoballoon group (P<0.0001 and P=0.006, respectively). There were no significant between-group differences in the incidence of thrombotic or bleeding events.Conclusions:Uninterrupted edoxaban concentrations were similar in both groups. Both myocardial injury and coagulation biomarkers increased after CA, especially with cryoballoon, but there was no difference in the incidence of thrombotic or bleeding events. These findings suggest the efficacy of uninterrupted edoxaban, regardless of the CA energy source. Periprocedural anticoagulation, particularly with cryoballoon, should be undertaken with care.</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>34275977</pmid><doi>10.1253/circj.CJ-21-0247</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anticoagulants Atrial Fibrillation - surgery Biomarkers Catheter ablation Catheter Ablation - adverse effects Catheter Ablation - methods Cryoballoon Heart Injuries Hemorrhage Humans Non-valvular atrial fibrillation Pyridines Thiazoles Treatment Outcome |
| title | Catheter Ablation Energy Sources and Myocardial Injury and Coagulation Biomarkers During Uninterrupted Periprocedural Edoxaban Use ― A Subanalysis of KYU-RABLE |
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