Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticles

Lipid Nanoparticles (LNPs) are a promising drug delivery vehicle for clinical siRNA delivery. Modified mRNA (modRNA) has recently gained great attention as a therapeutic molecule in cardiac regeneration. However, for mRNA to be functional, it must first reach the diseased myocardium, enter the targe...

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Veröffentlicht in:	Journal of controlled release 2022-03, Vol.343, p.207-216
Hauptverfasser:	Evers, Martijn J.W., Du, Wenjuan, Yang, Qiangbing, Kooijmans, Sander A.A., Vink, Aryan, van Steenbergen, Mies, Vader, Pieter, de Jager, Saskia C.A., Fuchs, Sabine A., Mastrobattista, Enrico, Sluijter, Joost P.G., Lei, Zhiyong, Schiffelers, Raymond
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Infarction Lipid nanoparticles Liposomes Luciferases, Firefly Mice Modified mRNA Myocardial infarction Myocardium Nanoparticles Reperfusion injury RNA, Messenger RNA, Small Interfering - genetics Systemic delivery
Online-Zugang:	Volltext
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