Serotonin-1A receptor activation in the median raphe nucleus improves response learning-based strategy in 192IgG saporin-induced cognitive impairments

Deficits in the translation between egocentric-allocentric strategies may become another diagnostic mark for neurodegenerative disorders, especially Alzheimer's disease. Regarding the specific regional distribution of serotonin-1A receptor in brain areas mediating allocentric (externally-center...

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Veröffentlicht in:	European journal of pharmacology 2022-03, Vol.918, p.174774-174774, Article 174774
Hauptverfasser:	Ramezani, Farangis, Salehian, Sara, Hosseinzadeh, Soheila, Mahjour, Zahra, Babajani, Tahereh, Ghorbanian, Davoud, Feizi, Farideh, Pourbagher, Roghayeh
Format:	Artikel
Sprache:	eng
Schlagworte:	192 IgG saporin 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Animals Antibodies, Monoclonal - pharmacology Brain - drug effects Brain - metabolism Cholinergic Agents - pharmacology Cognition - drug effects Cognition - physiology Hippocampus Infusions, Intraventricular Learning Medial septal Median raphe nucleus Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - metabolism Piperazines - pharmacology Pyridines - pharmacology Raphe Nuclei - drug effects Raphe Nuclei - metabolism Rats Rats, Wistar Receptor, Serotonin, 5-HT1A - metabolism Saporins - pharmacology Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology Serotonin-1A Spatial navigation Spatial Navigation - drug effects Spatial Navigation - physiology
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