Stabilization of VEGF i-motif structure by CpG methylation

The intercalated motif (i-motif) is a non-canonical nucleic acid structure formed by intercalated hemi-protonated cytosine base pairs (C–C+) under acidic conditions. The i-motif structure formation is involved in biological processes such as transcription regulation. Therefore, the identification of...

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Veröffentlicht in:	Biochemical and biophysical research communications 2022-02, Vol.594, p.88-92
Hauptverfasser:	Kimura, Kosuke, Oshikawa, Daiki, Ikebukuro, Kazunori, Yoshida, Wataru
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Buffers Circular Dichroism CpG Islands CpG methylation Cytosine - chemistry DNA Methylation G-Quadruplexes Humans Hydrogen-Ion Concentration i-motif Intercalating Agents Nucleic Acid Conformation Oligonucleotides - chemistry Protein Structure, Secondary Temperature Thermal stability Vascular Endothelial Growth Factor A - chemistry Vascular Endothelial Growth Factor A - metabolism VEGF
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