The effect of Zataria multiflora on respiratory allergic and immunologic disorders, experimental and clinical evidence: A comprehensive review
Zataria multiflora (Z. multiflora) is used in traditional and modern medicine for therapeutic objectives especially in respiratory disorders. Therefore, updated experimental and clinical studies on the effects of Z. multiflora on respiratory, allergic, and immunologic disorders are reviewed. Various...
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| Veröffentlicht in: | Phytotherapy research 2022-03, Vol.36 (3), p.1135-1155 |
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| creator | Ghorani, Vahideh Beigoli, Sima Khazdair, Mahammad Reza Boskabady, Mohammad Hossein |
| description | Zataria multiflora (Z. multiflora) is used in traditional and modern medicine for therapeutic objectives especially in respiratory disorders. Therefore, updated experimental and clinical studies on the effects of Z. multiflora on respiratory, allergic, and immunologic disorders are reviewed. Various electronic search engines including PubMed, Science Direct, Scopus, and Google Scholar were searched using appropriate keywords until the end of November 2021. Books, thesis‐hard copies of some articles were also included. The effects of Z. multiflora on respiratory disorders including asthma, chronic obstructive pulmonary disease (COPD), lung infection, and lung cancer were shown. Extracts of Z. multiflora showed the relaxant effect with various mechanisms. The preventive effects of Z. multiflora were also demonstrated by mechanisms such as antioxidant, immunomodulatory, and antiinflammatory properties in the experimental animal models of different respiratory diseases. Carvacrol and thymol are probably responsible for the therapeutic effect of plant among 56 constituents of Z. multiflora. In addition, bronchodilatory and preventive effects of the plant and its constituents on asthma, COPD, lung disorders due to noxious agents and allergic and immunologic disorders were shown in the clinical studies. Therefore Z. multiflora and its constituents may be considered as a preventive and/or relieving therapy in various respiratory diseases. |
| doi_str_mv | 10.1002/ptr.7382 |
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Therefore, updated experimental and clinical studies on the effects of Z. multiflora on respiratory, allergic, and immunologic disorders are reviewed. Various electronic search engines including PubMed, Science Direct, Scopus, and Google Scholar were searched using appropriate keywords until the end of November 2021. Books, thesis‐hard copies of some articles were also included. The effects of Z. multiflora on respiratory disorders including asthma, chronic obstructive pulmonary disease (COPD), lung infection, and lung cancer were shown. Extracts of Z. multiflora showed the relaxant effect with various mechanisms. The preventive effects of Z. multiflora were also demonstrated by mechanisms such as antioxidant, immunomodulatory, and antiinflammatory properties in the experimental animal models of different respiratory diseases. Carvacrol and thymol are probably responsible for the therapeutic effect of plant among 56 constituents of Z. multiflora. In addition, bronchodilatory and preventive effects of the plant and its constituents on asthma, COPD, lung disorders due to noxious agents and allergic and immunologic disorders were shown in the clinical studies. Therefore Z. multiflora and its constituents may be considered as a preventive and/or relieving therapy in various respiratory diseases.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.7382</identifier><identifier>PMID: 35080049</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>allergy ; Animal models ; Animals ; Anti-inflammatory agents ; Anti-Inflammatory Agents - pharmacology ; Antioxidants ; Asthma ; Bronchodilators ; Bronchopulmonary infection ; Carvacrol ; Chronic infection ; Chronic obstructive pulmonary disease ; Constituents ; Humans ; Hypersensitivity ; Immunological diseases ; Immunomodulation ; Lamiaceae ; Lung cancer ; Lung diseases ; Obstructive lung disease ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Respiratory diseases ; Search engines ; Shirazi thyme ; Thymol ; Zataria multiflora</subject><ispartof>Phytotherapy research, 2022-03, Vol.36 (3), p.1135-1155</ispartof><rights>2022 John Wiley & Sons Ltd.</rights><rights>2022 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3492-d45f7fa65f1fb64f248f1333290a2bbf53973dc2c2c36868ff6248be6d17cb803</citedby><cites>FETCH-LOGICAL-c3492-d45f7fa65f1fb64f248f1333290a2bbf53973dc2c2c36868ff6248be6d17cb803</cites><orcidid>0000-0001-6883-7972 ; 0000-0001-5736-9755 ; 0000-0001-9854-6121</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.7382$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.7382$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35080049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghorani, Vahideh</creatorcontrib><creatorcontrib>Beigoli, Sima</creatorcontrib><creatorcontrib>Khazdair, Mahammad Reza</creatorcontrib><creatorcontrib>Boskabady, Mohammad Hossein</creatorcontrib><title>The effect of Zataria multiflora on respiratory allergic and immunologic disorders, experimental and clinical evidence: A comprehensive review</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>Zataria multiflora (Z. multiflora) is used in traditional and modern medicine for therapeutic objectives especially in respiratory disorders. Therefore, updated experimental and clinical studies on the effects of Z. multiflora on respiratory, allergic, and immunologic disorders are reviewed. Various electronic search engines including PubMed, Science Direct, Scopus, and Google Scholar were searched using appropriate keywords until the end of November 2021. Books, thesis‐hard copies of some articles were also included. The effects of Z. multiflora on respiratory disorders including asthma, chronic obstructive pulmonary disease (COPD), lung infection, and lung cancer were shown. Extracts of Z. multiflora showed the relaxant effect with various mechanisms. The preventive effects of Z. multiflora were also demonstrated by mechanisms such as antioxidant, immunomodulatory, and antiinflammatory properties in the experimental animal models of different respiratory diseases. Carvacrol and thymol are probably responsible for the therapeutic effect of plant among 56 constituents of Z. multiflora. In addition, bronchodilatory and preventive effects of the plant and its constituents on asthma, COPD, lung disorders due to noxious agents and allergic and immunologic disorders were shown in the clinical studies. Therefore Z. multiflora and its constituents may be considered as a preventive and/or relieving therapy in various respiratory diseases.</description><subject>allergy</subject><subject>Animal models</subject><subject>Animals</subject><subject>Anti-inflammatory agents</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antioxidants</subject><subject>Asthma</subject><subject>Bronchodilators</subject><subject>Bronchopulmonary infection</subject><subject>Carvacrol</subject><subject>Chronic infection</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Constituents</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Immunological diseases</subject><subject>Immunomodulation</subject><subject>Lamiaceae</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Obstructive lung disease</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Respiratory diseases</subject><subject>Search engines</subject><subject>Shirazi thyme</subject><subject>Thymol</subject><subject>Zataria multiflora</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd9qFTEQh4Mo9rQKPoEEvOmF2-bf7ibelaK2ULDIEcSbJZud2JRssia7p56n6Cv4LD6ZOW1VEGQuhoGPb4b5IfSCkiNKCDue5nTUcskeoRUlSlW0bvljtCKqppWg8vMe2s_5mhCiGBFP0R6viSREqBW6XV8BBmvBzDha_EXPOjmNx8XPzvqYNI4BJ8iTS3qOaYu195C-OoN1GLAbxyVEH3fz4HJMA6T8GsP3CZIbIcza33HGu-BMGWDjBggG3uCTnz9MHKcEVxCy20BZsnFw8ww9sdpneP7QD9Cnd2_Xp2fVxYf356cnF5XhQrFqELVtrW5qS23fCMuEtJRzzhTRrO9tzVXLB8NK8UY20tqmID00A21NLwk_QIf33inFbwvkuRtdNuC9DhCX3LGGMdVwwWlBX_2DXsclhXJdoQQjUtSt_Cs0KeacwHZTeYFO246SbhdSV0LqdiEV9OWDcOlHGP6Av1MpQHUP3DgP2_-Kusv1xzvhL_4_nmM</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Ghorani, Vahideh</creator><creator>Beigoli, Sima</creator><creator>Khazdair, Mahammad Reza</creator><creator>Boskabady, Mohammad Hossein</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6883-7972</orcidid><orcidid>https://orcid.org/0000-0001-5736-9755</orcidid><orcidid>https://orcid.org/0000-0001-9854-6121</orcidid></search><sort><creationdate>202203</creationdate><title>The effect of Zataria multiflora on respiratory allergic and immunologic disorders, experimental and clinical evidence: A comprehensive review</title><author>Ghorani, Vahideh ; Beigoli, Sima ; Khazdair, Mahammad Reza ; Boskabady, Mohammad Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3492-d45f7fa65f1fb64f248f1333290a2bbf53973dc2c2c36868ff6248be6d17cb803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>allergy</topic><topic>Animal models</topic><topic>Animals</topic><topic>Anti-inflammatory agents</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antioxidants</topic><topic>Asthma</topic><topic>Bronchodilators</topic><topic>Bronchopulmonary infection</topic><topic>Carvacrol</topic><topic>Chronic infection</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Constituents</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Immunological diseases</topic><topic>Immunomodulation</topic><topic>Lamiaceae</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Obstructive lung disease</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Respiratory diseases</topic><topic>Search engines</topic><topic>Shirazi thyme</topic><topic>Thymol</topic><topic>Zataria multiflora</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghorani, Vahideh</creatorcontrib><creatorcontrib>Beigoli, Sima</creatorcontrib><creatorcontrib>Khazdair, Mahammad Reza</creatorcontrib><creatorcontrib>Boskabady, Mohammad Hossein</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghorani, Vahideh</au><au>Beigoli, Sima</au><au>Khazdair, Mahammad Reza</au><au>Boskabady, Mohammad Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of Zataria multiflora on respiratory allergic and immunologic disorders, experimental and clinical evidence: A comprehensive review</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2022-03</date><risdate>2022</risdate><volume>36</volume><issue>3</issue><spage>1135</spage><epage>1155</epage><pages>1135-1155</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Zataria multiflora (Z. multiflora) is used in traditional and modern medicine for therapeutic objectives especially in respiratory disorders. Therefore, updated experimental and clinical studies on the effects of Z. multiflora on respiratory, allergic, and immunologic disorders are reviewed. Various electronic search engines including PubMed, Science Direct, Scopus, and Google Scholar were searched using appropriate keywords until the end of November 2021. Books, thesis‐hard copies of some articles were also included. The effects of Z. multiflora on respiratory disorders including asthma, chronic obstructive pulmonary disease (COPD), lung infection, and lung cancer were shown. Extracts of Z. multiflora showed the relaxant effect with various mechanisms. The preventive effects of Z. multiflora were also demonstrated by mechanisms such as antioxidant, immunomodulatory, and antiinflammatory properties in the experimental animal models of different respiratory diseases. Carvacrol and thymol are probably responsible for the therapeutic effect of plant among 56 constituents of Z. multiflora. In addition, bronchodilatory and preventive effects of the plant and its constituents on asthma, COPD, lung disorders due to noxious agents and allergic and immunologic disorders were shown in the clinical studies. Therefore Z. multiflora and its constituents may be considered as a preventive and/or relieving therapy in various respiratory diseases.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>35080049</pmid><doi>10.1002/ptr.7382</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0001-6883-7972</orcidid><orcidid>https://orcid.org/0000-0001-5736-9755</orcidid><orcidid>https://orcid.org/0000-0001-9854-6121</orcidid></addata></record> |
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| subjects | allergy Animal models Animals Anti-inflammatory agents Anti-Inflammatory Agents - pharmacology Antioxidants Asthma Bronchodilators Bronchopulmonary infection Carvacrol Chronic infection Chronic obstructive pulmonary disease Constituents Humans Hypersensitivity Immunological diseases Immunomodulation Lamiaceae Lung cancer Lung diseases Obstructive lung disease Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Respiratory diseases Search engines Shirazi thyme Thymol Zataria multiflora |
| title | The effect of Zataria multiflora on respiratory allergic and immunologic disorders, experimental and clinical evidence: A comprehensive review |
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