The value of SPARCC sacroiliac MRI scoring in axial psoriatic arthritis and its association with other disease parameters
Objectives This study aimed to assess patients with axial psoriatic arthritis (AxPsA) using the Canadian Spondyloarthritis Research Consortium (SPARCC) sacroiliac joint (SIJ) scores and to seek correlations between magnetic resonance imaging (MRI) scores and disease characteristics. Methods Forty Ps...
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| Veröffentlicht in: | International journal of rheumatic diseases 2022-04, Vol.25 (4), p.433-439 |
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| creator | Gezer, Halise Hande Duruöz, Mehmet Tuncay |
| description | Objectives
This study aimed to assess patients with axial psoriatic arthritis (AxPsA) using the Canadian Spondyloarthritis Research Consortium (SPARCC) sacroiliac joint (SIJ) scores and to seek correlations between magnetic resonance imaging (MRI) scores and disease characteristics.
Methods
Forty PsA patients (32 females, mean age 46.4 years) who had been documented to have active or structural lesions on SIJ MRI were retrospectively evaluated. Disease duration, medications, and disease activity, including Disease Activity in Psoriatic Arthritis (DAPSA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), minimal disease activity (MDA), and Ankylosing Spondylitis Disease Activity Score (ASDAS) were recorded. On sacroiliac MRI scans, the SPARCC scores of sacroiliac joint inflammation (SIS) and sacroiliac joint structural damage (SSS) were evaluated.
Results
The mean disease duration was 51.4 ± 70.4 months. MRI showed active inflammation in 30 patients (75%) and at least 1 structural lesion in 32 patients (92.5%). The most prevalent structural lesion was erosion (82.5%), followed by fat metaplasia (65%), backfill (12.5%), and ankylosis (2.5%). Only fat metaplasia scores were significantly higher in men than in women (P = .007). Of clinical and laboratory parameters, only C‐reactive protein (CRP) was significantly higher in the presence of active inflammation (P = .01). The SIS score was significantly correlated with disease duration (r = −.35) and CRP levels (r = .42,). The SSS score was inversely correlated with BASDAI (r = −.37), ASDAS‐CRP (r = −.39), and ASDAS – erythrocyte sedimentation rate (r = −.32). The overall SPARCC scores did not differ between patients in DAPSA remission and non‐remission and between those in MDA and non‐MDA.
Conclusion
Although radiologic involvement is generally not severe in AxPsA, MRI still provides additional information about inflammatory activity and structural lesions. CRP may be helpful in monitoring the radiologic disease activity in AxPsA. |
| doi_str_mv | 10.1111/1756-185X.14285 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2622963398</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2649167911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3715-248eca871269becc200a2893d6cc37d1e718d090a5a29843ac4d65defc1c86f63</originalsourceid><addsrcrecordid>eNqFkUFvFDEMhSNERUvhzA1F4tLLtnFmJpM5rlYFKi2iKkXiFrkZD5tqdrLEM7T778myZQ9c6ost-_OT5SfEO1DnkOMC6srMwFY_zqHUtnohTg6dl4e6hGPxmvleKQOFqV-J46JSVoEuT8T2dkXyN_YTydjJb9fzm8VCMvoUQx_Qyy83V5J9TGH4KcMg8TFgLzecGzgGLzGNqxTGwBKHVoYxZ-bod8M4yIcwrmQcV5RkG5iQSW4w4ZpGSvxGHHXYM719yqfi-8fL28Xn2fLrp6vFfDnzRQ3VTJeWPNoatGnuyHutFGrbFK3xGWiBarCtahRWqBtbFujL1lQtdR68NZ0pTsXZXneT4q-JeHTrwJ76HgeKEztttG5MUTQ2ox_-Q-_jlIZ8XabKBkzdAGTqYk_lJzEn6twmhTWmrQPldq643d_dzgP315W88f5Jd7pbU3vg_9mQgWoPPISets_pufn1ci_8B6wylzY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2649167911</pqid></control><display><type>article</type><title>The value of SPARCC sacroiliac MRI scoring in axial psoriatic arthritis and its association with other disease parameters</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Gezer, Halise Hande ; Duruöz, Mehmet Tuncay</creator><creatorcontrib>Gezer, Halise Hande ; Duruöz, Mehmet Tuncay</creatorcontrib><description>Objectives
This study aimed to assess patients with axial psoriatic arthritis (AxPsA) using the Canadian Spondyloarthritis Research Consortium (SPARCC) sacroiliac joint (SIJ) scores and to seek correlations between magnetic resonance imaging (MRI) scores and disease characteristics.
Methods
Forty PsA patients (32 females, mean age 46.4 years) who had been documented to have active or structural lesions on SIJ MRI were retrospectively evaluated. Disease duration, medications, and disease activity, including Disease Activity in Psoriatic Arthritis (DAPSA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), minimal disease activity (MDA), and Ankylosing Spondylitis Disease Activity Score (ASDAS) were recorded. On sacroiliac MRI scans, the SPARCC scores of sacroiliac joint inflammation (SIS) and sacroiliac joint structural damage (SSS) were evaluated.
Results
The mean disease duration was 51.4 ± 70.4 months. MRI showed active inflammation in 30 patients (75%) and at least 1 structural lesion in 32 patients (92.5%). The most prevalent structural lesion was erosion (82.5%), followed by fat metaplasia (65%), backfill (12.5%), and ankylosis (2.5%). Only fat metaplasia scores were significantly higher in men than in women (P = .007). Of clinical and laboratory parameters, only C‐reactive protein (CRP) was significantly higher in the presence of active inflammation (P = .01). The SIS score was significantly correlated with disease duration (r = −.35) and CRP levels (r = .42,). The SSS score was inversely correlated with BASDAI (r = −.37), ASDAS‐CRP (r = −.39), and ASDAS – erythrocyte sedimentation rate (r = −.32). The overall SPARCC scores did not differ between patients in DAPSA remission and non‐remission and between those in MDA and non‐MDA.
Conclusion
Although radiologic involvement is generally not severe in AxPsA, MRI still provides additional information about inflammatory activity and structural lesions. CRP may be helpful in monitoring the radiologic disease activity in AxPsA.</description><identifier>ISSN: 1756-1841</identifier><identifier>EISSN: 1756-185X</identifier><identifier>DOI: 10.1111/1756-185X.14285</identifier><identifier>PMID: 35080124</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Ankylosing spondylitis ; Ankylosis ; Arthritis ; Arthritis, Psoriatic - diagnostic imaging ; C-Reactive Protein ; Canada ; disease activity ; Erythrocyte sedimentation rate ; Female ; Humans ; Inflammation ; Inflammation - pathology ; Inflammatory diseases ; Lesions ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Metaplasia ; Metaplasia - pathology ; Middle Aged ; MRI ; Patients ; Psoriatic arthritis ; Remission ; Remission (Medicine) ; Retrospective Studies ; Rheumatic diseases ; Sacroiliac Joint - diagnostic imaging ; Sacroiliac Joint - pathology ; Sacroiliitis - diagnostic imaging ; Severity of Illness Index ; Spondylarthritis - drug therapy ; Spondylitis, Ankylosing - drug therapy ; structural damage</subject><ispartof>International journal of rheumatic diseases, 2022-04, Vol.25 (4), p.433-439</ispartof><rights>2022 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.</rights><rights>International Journal of Rheumatic Diseases © 2022 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3715-248eca871269becc200a2893d6cc37d1e718d090a5a29843ac4d65defc1c86f63</citedby><cites>FETCH-LOGICAL-c3715-248eca871269becc200a2893d6cc37d1e718d090a5a29843ac4d65defc1c86f63</cites><orcidid>0000-0001-8790-304X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1756-185X.14285$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1756-185X.14285$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35080124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gezer, Halise Hande</creatorcontrib><creatorcontrib>Duruöz, Mehmet Tuncay</creatorcontrib><title>The value of SPARCC sacroiliac MRI scoring in axial psoriatic arthritis and its association with other disease parameters</title><title>International journal of rheumatic diseases</title><addtitle>Int J Rheum Dis</addtitle><description>Objectives
This study aimed to assess patients with axial psoriatic arthritis (AxPsA) using the Canadian Spondyloarthritis Research Consortium (SPARCC) sacroiliac joint (SIJ) scores and to seek correlations between magnetic resonance imaging (MRI) scores and disease characteristics.
Methods
Forty PsA patients (32 females, mean age 46.4 years) who had been documented to have active or structural lesions on SIJ MRI were retrospectively evaluated. Disease duration, medications, and disease activity, including Disease Activity in Psoriatic Arthritis (DAPSA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), minimal disease activity (MDA), and Ankylosing Spondylitis Disease Activity Score (ASDAS) were recorded. On sacroiliac MRI scans, the SPARCC scores of sacroiliac joint inflammation (SIS) and sacroiliac joint structural damage (SSS) were evaluated.
Results
The mean disease duration was 51.4 ± 70.4 months. MRI showed active inflammation in 30 patients (75%) and at least 1 structural lesion in 32 patients (92.5%). The most prevalent structural lesion was erosion (82.5%), followed by fat metaplasia (65%), backfill (12.5%), and ankylosis (2.5%). Only fat metaplasia scores were significantly higher in men than in women (P = .007). Of clinical and laboratory parameters, only C‐reactive protein (CRP) was significantly higher in the presence of active inflammation (P = .01). The SIS score was significantly correlated with disease duration (r = −.35) and CRP levels (r = .42,). The SSS score was inversely correlated with BASDAI (r = −.37), ASDAS‐CRP (r = −.39), and ASDAS – erythrocyte sedimentation rate (r = −.32). The overall SPARCC scores did not differ between patients in DAPSA remission and non‐remission and between those in MDA and non‐MDA.
Conclusion
Although radiologic involvement is generally not severe in AxPsA, MRI still provides additional information about inflammatory activity and structural lesions. CRP may be helpful in monitoring the radiologic disease activity in AxPsA.</description><subject>Ankylosing spondylitis</subject><subject>Ankylosis</subject><subject>Arthritis</subject><subject>Arthritis, Psoriatic - diagnostic imaging</subject><subject>C-Reactive Protein</subject><subject>Canada</subject><subject>disease activity</subject><subject>Erythrocyte sedimentation rate</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - pathology</subject><subject>Inflammatory diseases</subject><subject>Lesions</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Metaplasia</subject><subject>Metaplasia - pathology</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Patients</subject><subject>Psoriatic arthritis</subject><subject>Remission</subject><subject>Remission (Medicine)</subject><subject>Retrospective Studies</subject><subject>Rheumatic diseases</subject><subject>Sacroiliac Joint - diagnostic imaging</subject><subject>Sacroiliac Joint - pathology</subject><subject>Sacroiliitis - diagnostic imaging</subject><subject>Severity of Illness Index</subject><subject>Spondylarthritis - drug therapy</subject><subject>Spondylitis, Ankylosing - drug therapy</subject><subject>structural damage</subject><issn>1756-1841</issn><issn>1756-185X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvFDEMhSNERUvhzA1F4tLLtnFmJpM5rlYFKi2iKkXiFrkZD5tqdrLEM7T778myZQ9c6ost-_OT5SfEO1DnkOMC6srMwFY_zqHUtnohTg6dl4e6hGPxmvleKQOFqV-J46JSVoEuT8T2dkXyN_YTydjJb9fzm8VCMvoUQx_Qyy83V5J9TGH4KcMg8TFgLzecGzgGLzGNqxTGwBKHVoYxZ-bod8M4yIcwrmQcV5RkG5iQSW4w4ZpGSvxGHHXYM719yqfi-8fL28Xn2fLrp6vFfDnzRQ3VTJeWPNoatGnuyHutFGrbFK3xGWiBarCtahRWqBtbFujL1lQtdR68NZ0pTsXZXneT4q-JeHTrwJ76HgeKEztttG5MUTQ2ox_-Q-_jlIZ8XabKBkzdAGTqYk_lJzEn6twmhTWmrQPldq643d_dzgP315W88f5Jd7pbU3vg_9mQgWoPPISets_pufn1ci_8B6wylzY</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Gezer, Halise Hande</creator><creator>Duruöz, Mehmet Tuncay</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8790-304X</orcidid></search><sort><creationdate>202204</creationdate><title>The value of SPARCC sacroiliac MRI scoring in axial psoriatic arthritis and its association with other disease parameters</title><author>Gezer, Halise Hande ; Duruöz, Mehmet Tuncay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3715-248eca871269becc200a2893d6cc37d1e718d090a5a29843ac4d65defc1c86f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Ankylosing spondylitis</topic><topic>Ankylosis</topic><topic>Arthritis</topic><topic>Arthritis, Psoriatic - diagnostic imaging</topic><topic>C-Reactive Protein</topic><topic>Canada</topic><topic>disease activity</topic><topic>Erythrocyte sedimentation rate</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - pathology</topic><topic>Inflammatory diseases</topic><topic>Lesions</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Metaplasia</topic><topic>Metaplasia - pathology</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Patients</topic><topic>Psoriatic arthritis</topic><topic>Remission</topic><topic>Remission (Medicine)</topic><topic>Retrospective Studies</topic><topic>Rheumatic diseases</topic><topic>Sacroiliac Joint - diagnostic imaging</topic><topic>Sacroiliac Joint - pathology</topic><topic>Sacroiliitis - diagnostic imaging</topic><topic>Severity of Illness Index</topic><topic>Spondylarthritis - drug therapy</topic><topic>Spondylitis, Ankylosing - drug therapy</topic><topic>structural damage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gezer, Halise Hande</creatorcontrib><creatorcontrib>Duruöz, Mehmet Tuncay</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gezer, Halise Hande</au><au>Duruöz, Mehmet Tuncay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The value of SPARCC sacroiliac MRI scoring in axial psoriatic arthritis and its association with other disease parameters</atitle><jtitle>International journal of rheumatic diseases</jtitle><addtitle>Int J Rheum Dis</addtitle><date>2022-04</date><risdate>2022</risdate><volume>25</volume><issue>4</issue><spage>433</spage><epage>439</epage><pages>433-439</pages><issn>1756-1841</issn><eissn>1756-185X</eissn><abstract>Objectives
This study aimed to assess patients with axial psoriatic arthritis (AxPsA) using the Canadian Spondyloarthritis Research Consortium (SPARCC) sacroiliac joint (SIJ) scores and to seek correlations between magnetic resonance imaging (MRI) scores and disease characteristics.
Methods
Forty PsA patients (32 females, mean age 46.4 years) who had been documented to have active or structural lesions on SIJ MRI were retrospectively evaluated. Disease duration, medications, and disease activity, including Disease Activity in Psoriatic Arthritis (DAPSA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), minimal disease activity (MDA), and Ankylosing Spondylitis Disease Activity Score (ASDAS) were recorded. On sacroiliac MRI scans, the SPARCC scores of sacroiliac joint inflammation (SIS) and sacroiliac joint structural damage (SSS) were evaluated.
Results
The mean disease duration was 51.4 ± 70.4 months. MRI showed active inflammation in 30 patients (75%) and at least 1 structural lesion in 32 patients (92.5%). The most prevalent structural lesion was erosion (82.5%), followed by fat metaplasia (65%), backfill (12.5%), and ankylosis (2.5%). Only fat metaplasia scores were significantly higher in men than in women (P = .007). Of clinical and laboratory parameters, only C‐reactive protein (CRP) was significantly higher in the presence of active inflammation (P = .01). The SIS score was significantly correlated with disease duration (r = −.35) and CRP levels (r = .42,). The SSS score was inversely correlated with BASDAI (r = −.37), ASDAS‐CRP (r = −.39), and ASDAS – erythrocyte sedimentation rate (r = −.32). The overall SPARCC scores did not differ between patients in DAPSA remission and non‐remission and between those in MDA and non‐MDA.
Conclusion
Although radiologic involvement is generally not severe in AxPsA, MRI still provides additional information about inflammatory activity and structural lesions. CRP may be helpful in monitoring the radiologic disease activity in AxPsA.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35080124</pmid><doi>10.1111/1756-185X.14285</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8790-304X</orcidid></addata></record> |
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| subjects | Ankylosing spondylitis Ankylosis Arthritis Arthritis, Psoriatic - diagnostic imaging C-Reactive Protein Canada disease activity Erythrocyte sedimentation rate Female Humans Inflammation Inflammation - pathology Inflammatory diseases Lesions Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Metaplasia Metaplasia - pathology Middle Aged MRI Patients Psoriatic arthritis Remission Remission (Medicine) Retrospective Studies Rheumatic diseases Sacroiliac Joint - diagnostic imaging Sacroiliac Joint - pathology Sacroiliitis - diagnostic imaging Severity of Illness Index Spondylarthritis - drug therapy Spondylitis, Ankylosing - drug therapy structural damage |
| title | The value of SPARCC sacroiliac MRI scoring in axial psoriatic arthritis and its association with other disease parameters |
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