The onset, development and pathogenesis of severe neutrophilic asthma
Bronchial asthma is divided into Th2 high, Th2 low and mixed types. The Th2 high type is dominated by eosinophils while the Th2 low type is divided into neutrophilic and paucigranulocytic types. Eosinophilic asthma has gained increased attention recently, and its pathogenesis and treatment are well...
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| Veröffentlicht in: | Immunology and cell biology 2022-03, Vol.100 (3), p.144-159 |
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| creator | Zhang, Xingli Xu, Zixi Wen, Xue Huang, Guoping Nian, Siji Li, Lin Guo, Xiyuan Ye, Yingchun Yuan, Qing |
| description | Bronchial asthma is divided into Th2 high, Th2 low and mixed types. The Th2 high type is dominated by eosinophils while the Th2 low type is divided into neutrophilic and paucigranulocytic types. Eosinophilic asthma has gained increased attention recently, and its pathogenesis and treatment are well understood. However, severe neutrophilic asthma requires more in‐depth research because its pathogenesis is not well understood, and no effective treatment exists. This review looks at the advances made in asthma research, the pathogenesis of neutrophilic asthma, the mechanisms of progression to severe asthma, risk factors for asthma exacerbations, and biomarkers and treatment of neutrophilic asthma. The pathogenesis of neutrophilic asthma is further discussed from four aspects: Th17‐type inflammatory response, inflammasomes, exosomes and microRNAs. This review provides direction for the mechanistic study, diagnosis and treatment of neutrophilic asthma. The treatment of neutrophilic asthma remains a significant challenge for clinical therapists and is an important area of future clinical research.
Neutrophilic asthma is asthma in which neutrophils are predominantly increased. This review looks at the advances made in asthma research, the pathogenesis of neutrophilic asthma, the mechanism of progression to severe asthma, risk factors for asthma exacerbations, and biomarkers and treatment of neutrophilic asthma. This review provides direction for the prevention, diagnosis and treatment of severe asthma. |
| doi_str_mv | 10.1111/imcb.12522 |
| format | Article |
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Neutrophilic asthma is asthma in which neutrophils are predominantly increased. This review looks at the advances made in asthma research, the pathogenesis of neutrophilic asthma, the mechanism of progression to severe asthma, risk factors for asthma exacerbations, and biomarkers and treatment of neutrophilic asthma. This review provides direction for the prevention, diagnosis and treatment of severe asthma.</description><identifier>ISSN: 0818-9641</identifier><identifier>EISSN: 1440-1711</identifier><identifier>DOI: 10.1111/imcb.12522</identifier><identifier>PMID: 35080788</identifier><language>eng</language><publisher>United States: Blackwell Science Ltd</publisher><subject>Asthma ; Exosomes ; Helper cells ; Inflammasomes ; Inflammation ; inflammation, neutrophil asthma, pathogenesis, risk factors ; Leukocytes (eosinophilic) ; Leukocytes (neutrophilic) ; Lymphocytes T ; miRNA ; Pathogenesis ; Risk factors</subject><ispartof>Immunology and cell biology, 2022-03, Vol.100 (3), p.144-159</ispartof><rights>2022 Australian and New Zealand Society for Immunology, Inc.</rights><rights>Copyright © 2022 Australian and New Zealand Society for Immunology Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3572-89eb087dfaea52d5f34fe2b188ea2e53993f34a2a558678ace9461151c7f18e93</citedby><cites>FETCH-LOGICAL-c3572-89eb087dfaea52d5f34fe2b188ea2e53993f34a2a558678ace9461151c7f18e93</cites><orcidid>0000-0002-5829-1328</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fimcb.12522$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fimcb.12522$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35080788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Xingli</creatorcontrib><creatorcontrib>Xu, Zixi</creatorcontrib><creatorcontrib>Wen, Xue</creatorcontrib><creatorcontrib>Huang, Guoping</creatorcontrib><creatorcontrib>Nian, Siji</creatorcontrib><creatorcontrib>Li, Lin</creatorcontrib><creatorcontrib>Guo, Xiyuan</creatorcontrib><creatorcontrib>Ye, Yingchun</creatorcontrib><creatorcontrib>Yuan, Qing</creatorcontrib><title>The onset, development and pathogenesis of severe neutrophilic asthma</title><title>Immunology and cell biology</title><addtitle>Immunol Cell Biol</addtitle><description>Bronchial asthma is divided into Th2 high, Th2 low and mixed types. The Th2 high type is dominated by eosinophils while the Th2 low type is divided into neutrophilic and paucigranulocytic types. Eosinophilic asthma has gained increased attention recently, and its pathogenesis and treatment are well understood. However, severe neutrophilic asthma requires more in‐depth research because its pathogenesis is not well understood, and no effective treatment exists. This review looks at the advances made in asthma research, the pathogenesis of neutrophilic asthma, the mechanisms of progression to severe asthma, risk factors for asthma exacerbations, and biomarkers and treatment of neutrophilic asthma. The pathogenesis of neutrophilic asthma is further discussed from four aspects: Th17‐type inflammatory response, inflammasomes, exosomes and microRNAs. This review provides direction for the mechanistic study, diagnosis and treatment of neutrophilic asthma. The treatment of neutrophilic asthma remains a significant challenge for clinical therapists and is an important area of future clinical research.
Neutrophilic asthma is asthma in which neutrophils are predominantly increased. This review looks at the advances made in asthma research, the pathogenesis of neutrophilic asthma, the mechanism of progression to severe asthma, risk factors for asthma exacerbations, and biomarkers and treatment of neutrophilic asthma. This review provides direction for the prevention, diagnosis and treatment of severe asthma.</description><subject>Asthma</subject><subject>Exosomes</subject><subject>Helper cells</subject><subject>Inflammasomes</subject><subject>Inflammation</subject><subject>inflammation, neutrophil asthma, pathogenesis, risk factors</subject><subject>Leukocytes (eosinophilic)</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocytes T</subject><subject>miRNA</subject><subject>Pathogenesis</subject><subject>Risk factors</subject><issn>0818-9641</issn><issn>1440-1711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp90EFLwzAUB_AgipvTix9AAl5E7MxLmjY96pg6mHiZ55K2r66jbWrTKvv2ZnZ68GAuD_J-_Hn8CTkHNgX3bosqTabAJecHZAy-zzwIAQ7JmClQXhT4MCIn1m4YYyFX4piMhGSKhUqNyXy1Rmpqi90NzfADS9NUWHdU1xltdLc2b1ijLSw1ObVu3yKtse9a06yLskiptt260qfkKNelxbP9nJDXh_lq9uQtXx4Xs7ullwoZck9FmDAVZrlGLXkmc-HnyBNQCjVHKaJIuC_NtZQqCJVOMfIDAAlpmIPCSEzI1ZDbtOa9R9vFVWFTLEtdo-ltzAPOo4CDVI5e_qEb07e1u84pEXLBhc-cuh5U2hprW8zjpi0q3W5jYPGu3HhXbvxdrsMX-8g-qTD7pT9tOgAD-CxK3P4TFS-eZ_dD6Bd8b4Mk</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Zhang, Xingli</creator><creator>Xu, Zixi</creator><creator>Wen, Xue</creator><creator>Huang, Guoping</creator><creator>Nian, Siji</creator><creator>Li, Lin</creator><creator>Guo, Xiyuan</creator><creator>Ye, Yingchun</creator><creator>Yuan, Qing</creator><general>Blackwell Science Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5829-1328</orcidid></search><sort><creationdate>202203</creationdate><title>The onset, development and pathogenesis of severe neutrophilic asthma</title><author>Zhang, Xingli ; Xu, Zixi ; Wen, Xue ; Huang, Guoping ; Nian, Siji ; Li, Lin ; Guo, Xiyuan ; Ye, Yingchun ; Yuan, Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3572-89eb087dfaea52d5f34fe2b188ea2e53993f34a2a558678ace9461151c7f18e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Asthma</topic><topic>Exosomes</topic><topic>Helper cells</topic><topic>Inflammasomes</topic><topic>Inflammation</topic><topic>inflammation, neutrophil asthma, pathogenesis, risk factors</topic><topic>Leukocytes (eosinophilic)</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocytes T</topic><topic>miRNA</topic><topic>Pathogenesis</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xingli</creatorcontrib><creatorcontrib>Xu, Zixi</creatorcontrib><creatorcontrib>Wen, Xue</creatorcontrib><creatorcontrib>Huang, Guoping</creatorcontrib><creatorcontrib>Nian, Siji</creatorcontrib><creatorcontrib>Li, Lin</creatorcontrib><creatorcontrib>Guo, Xiyuan</creatorcontrib><creatorcontrib>Ye, Yingchun</creatorcontrib><creatorcontrib>Yuan, Qing</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology and cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xingli</au><au>Xu, Zixi</au><au>Wen, Xue</au><au>Huang, Guoping</au><au>Nian, Siji</au><au>Li, Lin</au><au>Guo, Xiyuan</au><au>Ye, Yingchun</au><au>Yuan, Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The onset, development and pathogenesis of severe neutrophilic asthma</atitle><jtitle>Immunology and cell biology</jtitle><addtitle>Immunol Cell Biol</addtitle><date>2022-03</date><risdate>2022</risdate><volume>100</volume><issue>3</issue><spage>144</spage><epage>159</epage><pages>144-159</pages><issn>0818-9641</issn><eissn>1440-1711</eissn><abstract>Bronchial asthma is divided into Th2 high, Th2 low and mixed types. The Th2 high type is dominated by eosinophils while the Th2 low type is divided into neutrophilic and paucigranulocytic types. Eosinophilic asthma has gained increased attention recently, and its pathogenesis and treatment are well understood. However, severe neutrophilic asthma requires more in‐depth research because its pathogenesis is not well understood, and no effective treatment exists. This review looks at the advances made in asthma research, the pathogenesis of neutrophilic asthma, the mechanisms of progression to severe asthma, risk factors for asthma exacerbations, and biomarkers and treatment of neutrophilic asthma. The pathogenesis of neutrophilic asthma is further discussed from four aspects: Th17‐type inflammatory response, inflammasomes, exosomes and microRNAs. This review provides direction for the mechanistic study, diagnosis and treatment of neutrophilic asthma. The treatment of neutrophilic asthma remains a significant challenge for clinical therapists and is an important area of future clinical research.
Neutrophilic asthma is asthma in which neutrophils are predominantly increased. This review looks at the advances made in asthma research, the pathogenesis of neutrophilic asthma, the mechanism of progression to severe asthma, risk factors for asthma exacerbations, and biomarkers and treatment of neutrophilic asthma. This review provides direction for the prevention, diagnosis and treatment of severe asthma.</abstract><cop>United States</cop><pub>Blackwell Science Ltd</pub><pmid>35080788</pmid><doi>10.1111/imcb.12522</doi><tpages>159</tpages><orcidid>https://orcid.org/0000-0002-5829-1328</orcidid></addata></record> |
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| subjects | Asthma Exosomes Helper cells Inflammasomes Inflammation inflammation, neutrophil asthma, pathogenesis, risk factors Leukocytes (eosinophilic) Leukocytes (neutrophilic) Lymphocytes T miRNA Pathogenesis Risk factors |
| title | The onset, development and pathogenesis of severe neutrophilic asthma |
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