The Prognostic Value of C-Reactive Protein/Albumin Ratio in Acute Mesenteric Ischemia
Background Diagnosis of acute mesenteric ischemia (AMI) in its early stages is important for reversing ischemic damage. The CRP to albumin (CRP/Alb) ratio has been defined as an inflammatory indicator and is associated with the severity of inflammation and mortality rates. However, the prognostic va...
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| Veröffentlicht in: | The American surgeon 2023-05, Vol.89 (5), p.1661-1667 |
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| description | Background
Diagnosis of acute mesenteric ischemia (AMI) in its early stages is important for reversing ischemic damage. The CRP to albumin (CRP/Alb) ratio has been defined as an inflammatory indicator and is associated with the severity of inflammation and mortality rates. However, the prognostic value of CRP/Alb has not been evaluated in patients with AMI. Here, we aimed to examine the prognostic significance of CRP/Alb and compare it with other inflammatory markers.
Materials and Methods
In this retrospective, case-control study, we included patients diagnosed with AMI at the emergency department between January 1, 2016, and December 31, 2020. In addition to demographic characteristics, lactate, D-dimer, white blood cell (WBC), CRP/Alb, and neutrophil/lymphocyte ratio (NLR) were recorded. Testing characteristics of CRP/Alb in predicting in-hospital mortality were studied.
Results
The mean age of 132 patients was 66.48 ± 15.95 years and 71 (53.8%) of them were male. The cut-off value obtained using the receiver operating characteristic (ROC) curve for in-hospital mortality was a CRP/Alb ratio of >1.32 (sensitivity, 93.65%; specificity, 69.57%; +LR, 3.08; −LR, .091; AUC, .782; 95% CI, .70-.85; P < .0001). The comparison of ROC curves between CRP/Alb and WBC, NLR, and lactate revealed a statistically significant difference (P < .05), whereas there was not any statistically significant difference between the ROC curves of CRP/Alb and D-dimer (P = .47).
Conclusion
C-reactive protein/albumin ratio is a powerful predictor of in-hospital mortality for AMI patients. It was superior to WBC, NLR, and lactate. It could be used to determine low-risk patients and help clinicians with treatment options. |
| doi_str_mv | 10.1177/00031348221074220 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2622659674</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_00031348221074220</sage_id><sourcerecordid>3066837689</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-a1577cb511ec0c20306f227bbc6c85280137b3c3f63994b346f321bf0098e7773</originalsourceid><addsrcrecordid>eNp1kE1Lw0AQhhdRbK3-AC8S8OIldT-yu8mxFD8KFaW0XsPuOmm3JNmaTQT_vVtbFRRPM8M87zvDi9A5wUNCpLzGGDPCkpRSgmVCKT5AfcI5j7OUskPU3-7jLdBDJ96vw5gITo5Rj3EsmZSyjxbzFURPjVvWzrfWRM-q7CByRTSOZ6BMa98-1y3Y-npU6q6ydTRTrXVRaEamayF6AA91C01QT7xZQWXVKToqVOnhbF8HaHF7Mx_fx9PHu8l4NI0NE2kbK8KlNJoTAgYbihkWBaVSayNMymmKCZOaGVYIlmWJZokoGCW6wDhLIbzPBuhq57tp3GsHvs0r6w2UparBdT6nglLBMyGTgF7-Qteua-rwXR7OipRJkWaBIjvKNM77Bop809hKNe85wfk28_xP5kFzsXfudAUv34qvkAMw3AFeLeHn7P-OH3z-he0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3066837689</pqid></control><display><type>article</type><title>The Prognostic Value of C-Reactive Protein/Albumin Ratio in Acute Mesenteric Ischemia</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><creator>Kaçer, İlker ; Çağlar, Ahmet ; Akıllı, Nazire Belgin</creator><creatorcontrib>Kaçer, İlker ; Çağlar, Ahmet ; Akıllı, Nazire Belgin</creatorcontrib><description>Background
Diagnosis of acute mesenteric ischemia (AMI) in its early stages is important for reversing ischemic damage. The CRP to albumin (CRP/Alb) ratio has been defined as an inflammatory indicator and is associated with the severity of inflammation and mortality rates. However, the prognostic value of CRP/Alb has not been evaluated in patients with AMI. Here, we aimed to examine the prognostic significance of CRP/Alb and compare it with other inflammatory markers.
Materials and Methods
In this retrospective, case-control study, we included patients diagnosed with AMI at the emergency department between January 1, 2016, and December 31, 2020. In addition to demographic characteristics, lactate, D-dimer, white blood cell (WBC), CRP/Alb, and neutrophil/lymphocyte ratio (NLR) were recorded. Testing characteristics of CRP/Alb in predicting in-hospital mortality were studied.
Results
The mean age of 132 patients was 66.48 ± 15.95 years and 71 (53.8%) of them were male. The cut-off value obtained using the receiver operating characteristic (ROC) curve for in-hospital mortality was a CRP/Alb ratio of >1.32 (sensitivity, 93.65%; specificity, 69.57%; +LR, 3.08; −LR, .091; AUC, .782; 95% CI, .70-.85; P < .0001). The comparison of ROC curves between CRP/Alb and WBC, NLR, and lactate revealed a statistically significant difference (P < .05), whereas there was not any statistically significant difference between the ROC curves of CRP/Alb and D-dimer (P = .47).
Conclusion
C-reactive protein/albumin ratio is a powerful predictor of in-hospital mortality for AMI patients. It was superior to WBC, NLR, and lactate. It could be used to determine low-risk patients and help clinicians with treatment options.</description><identifier>ISSN: 0003-1348</identifier><identifier>EISSN: 1555-9823</identifier><identifier>DOI: 10.1177/00031348221074220</identifier><identifier>PMID: 35073777</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Abdomen ; Abdominal surgery ; Aged, 80 and over ; Albumin ; Albumins ; Biomarkers ; Blood ; Body mass index ; C-reactive protein ; C-Reactive Protein - analysis ; Case-Control Studies ; Celiac disease ; Colorectal cancer ; Comorbidity ; Demographics ; Dimers ; Electrocardiography ; Embolisms ; Emergency medical care ; Emergency medical services ; Female ; Hematology ; Hospitals ; Humans ; Inflammation ; Inflammatory bowel disease ; Ischemia ; Lactates ; Lactic acid ; Length of stay ; Leukocytes ; Leukocytes (neutrophilic) ; Lymphocytes ; Male ; Mesenteric Ischemia - diagnosis ; Missing data ; Mortality ; Patients ; Prognosis ; Proteins ; Regression analysis ; Retrospective Studies ; Risk groups ; ROC Curve ; Serum Albumin ; Software ; Statistical analysis ; Thrombosis</subject><ispartof>The American surgeon, 2023-05, Vol.89 (5), p.1661-1667</ispartof><rights>The Author(s) 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-a1577cb511ec0c20306f227bbc6c85280137b3c3f63994b346f321bf0098e7773</citedby><cites>FETCH-LOGICAL-c368t-a1577cb511ec0c20306f227bbc6c85280137b3c3f63994b346f321bf0098e7773</cites><orcidid>0000-0002-9653-7958</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/00031348221074220$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/00031348221074220$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,777,781,21800,27905,27906,43602,43603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35073777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaçer, İlker</creatorcontrib><creatorcontrib>Çağlar, Ahmet</creatorcontrib><creatorcontrib>Akıllı, Nazire Belgin</creatorcontrib><title>The Prognostic Value of C-Reactive Protein/Albumin Ratio in Acute Mesenteric Ischemia</title><title>The American surgeon</title><addtitle>Am Surg</addtitle><description>Background
Diagnosis of acute mesenteric ischemia (AMI) in its early stages is important for reversing ischemic damage. The CRP to albumin (CRP/Alb) ratio has been defined as an inflammatory indicator and is associated with the severity of inflammation and mortality rates. However, the prognostic value of CRP/Alb has not been evaluated in patients with AMI. Here, we aimed to examine the prognostic significance of CRP/Alb and compare it with other inflammatory markers.
Materials and Methods
In this retrospective, case-control study, we included patients diagnosed with AMI at the emergency department between January 1, 2016, and December 31, 2020. In addition to demographic characteristics, lactate, D-dimer, white blood cell (WBC), CRP/Alb, and neutrophil/lymphocyte ratio (NLR) were recorded. Testing characteristics of CRP/Alb in predicting in-hospital mortality were studied.
Results
The mean age of 132 patients was 66.48 ± 15.95 years and 71 (53.8%) of them were male. The cut-off value obtained using the receiver operating characteristic (ROC) curve for in-hospital mortality was a CRP/Alb ratio of >1.32 (sensitivity, 93.65%; specificity, 69.57%; +LR, 3.08; −LR, .091; AUC, .782; 95% CI, .70-.85; P < .0001). The comparison of ROC curves between CRP/Alb and WBC, NLR, and lactate revealed a statistically significant difference (P < .05), whereas there was not any statistically significant difference between the ROC curves of CRP/Alb and D-dimer (P = .47).
Conclusion
C-reactive protein/albumin ratio is a powerful predictor of in-hospital mortality for AMI patients. It was superior to WBC, NLR, and lactate. It could be used to determine low-risk patients and help clinicians with treatment options.</description><subject>Abdomen</subject><subject>Abdominal surgery</subject><subject>Aged, 80 and over</subject><subject>Albumin</subject><subject>Albumins</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Body mass index</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Case-Control Studies</subject><subject>Celiac disease</subject><subject>Colorectal cancer</subject><subject>Comorbidity</subject><subject>Demographics</subject><subject>Dimers</subject><subject>Electrocardiography</subject><subject>Embolisms</subject><subject>Emergency medical care</subject><subject>Emergency medical services</subject><subject>Female</subject><subject>Hematology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Ischemia</subject><subject>Lactates</subject><subject>Lactic acid</subject><subject>Length of stay</subject><subject>Leukocytes</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Mesenteric Ischemia - diagnosis</subject><subject>Missing data</subject><subject>Mortality</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Risk groups</subject><subject>ROC Curve</subject><subject>Serum Albumin</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Thrombosis</subject><issn>0003-1348</issn><issn>1555-9823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1Lw0AQhhdRbK3-AC8S8OIldT-yu8mxFD8KFaW0XsPuOmm3JNmaTQT_vVtbFRRPM8M87zvDi9A5wUNCpLzGGDPCkpRSgmVCKT5AfcI5j7OUskPU3-7jLdBDJ96vw5gITo5Rj3EsmZSyjxbzFURPjVvWzrfWRM-q7CByRTSOZ6BMa98-1y3Y-npU6q6ydTRTrXVRaEamayF6AA91C01QT7xZQWXVKToqVOnhbF8HaHF7Mx_fx9PHu8l4NI0NE2kbK8KlNJoTAgYbihkWBaVSayNMymmKCZOaGVYIlmWJZokoGCW6wDhLIbzPBuhq57tp3GsHvs0r6w2UparBdT6nglLBMyGTgF7-Qteua-rwXR7OipRJkWaBIjvKNM77Bop809hKNe85wfk28_xP5kFzsXfudAUv34qvkAMw3AFeLeHn7P-OH3z-he0</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Kaçer, İlker</creator><creator>Çağlar, Ahmet</creator><creator>Akıllı, Nazire Belgin</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>4U-</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9653-7958</orcidid></search><sort><creationdate>202305</creationdate><title>The Prognostic Value of C-Reactive Protein/Albumin Ratio in Acute Mesenteric Ischemia</title><author>Kaçer, İlker ; Çağlar, Ahmet ; Akıllı, Nazire Belgin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-a1577cb511ec0c20306f227bbc6c85280137b3c3f63994b346f321bf0098e7773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abdomen</topic><topic>Abdominal surgery</topic><topic>Aged, 80 and over</topic><topic>Albumin</topic><topic>Albumins</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>Body mass index</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Case-Control Studies</topic><topic>Celiac disease</topic><topic>Colorectal cancer</topic><topic>Comorbidity</topic><topic>Demographics</topic><topic>Dimers</topic><topic>Electrocardiography</topic><topic>Embolisms</topic><topic>Emergency medical care</topic><topic>Emergency medical services</topic><topic>Female</topic><topic>Hematology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammatory bowel disease</topic><topic>Ischemia</topic><topic>Lactates</topic><topic>Lactic acid</topic><topic>Length of stay</topic><topic>Leukocytes</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Mesenteric Ischemia - diagnosis</topic><topic>Missing data</topic><topic>Mortality</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Risk groups</topic><topic>ROC Curve</topic><topic>Serum Albumin</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaçer, İlker</creatorcontrib><creatorcontrib>Çağlar, Ahmet</creatorcontrib><creatorcontrib>Akıllı, Nazire Belgin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American surgeon</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaçer, İlker</au><au>Çağlar, Ahmet</au><au>Akıllı, Nazire Belgin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Prognostic Value of C-Reactive Protein/Albumin Ratio in Acute Mesenteric Ischemia</atitle><jtitle>The American surgeon</jtitle><addtitle>Am Surg</addtitle><date>2023-05</date><risdate>2023</risdate><volume>89</volume><issue>5</issue><spage>1661</spage><epage>1667</epage><pages>1661-1667</pages><issn>0003-1348</issn><eissn>1555-9823</eissn><abstract>Background
Diagnosis of acute mesenteric ischemia (AMI) in its early stages is important for reversing ischemic damage. The CRP to albumin (CRP/Alb) ratio has been defined as an inflammatory indicator and is associated with the severity of inflammation and mortality rates. However, the prognostic value of CRP/Alb has not been evaluated in patients with AMI. Here, we aimed to examine the prognostic significance of CRP/Alb and compare it with other inflammatory markers.
Materials and Methods
In this retrospective, case-control study, we included patients diagnosed with AMI at the emergency department between January 1, 2016, and December 31, 2020. In addition to demographic characteristics, lactate, D-dimer, white blood cell (WBC), CRP/Alb, and neutrophil/lymphocyte ratio (NLR) were recorded. Testing characteristics of CRP/Alb in predicting in-hospital mortality were studied.
Results
The mean age of 132 patients was 66.48 ± 15.95 years and 71 (53.8%) of them were male. The cut-off value obtained using the receiver operating characteristic (ROC) curve for in-hospital mortality was a CRP/Alb ratio of >1.32 (sensitivity, 93.65%; specificity, 69.57%; +LR, 3.08; −LR, .091; AUC, .782; 95% CI, .70-.85; P < .0001). The comparison of ROC curves between CRP/Alb and WBC, NLR, and lactate revealed a statistically significant difference (P < .05), whereas there was not any statistically significant difference between the ROC curves of CRP/Alb and D-dimer (P = .47).
Conclusion
C-reactive protein/albumin ratio is a powerful predictor of in-hospital mortality for AMI patients. It was superior to WBC, NLR, and lactate. It could be used to determine low-risk patients and help clinicians with treatment options.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>35073777</pmid><doi>10.1177/00031348221074220</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9653-7958</orcidid></addata></record> |
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| subjects | Abdomen Abdominal surgery Aged, 80 and over Albumin Albumins Biomarkers Blood Body mass index C-reactive protein C-Reactive Protein - analysis Case-Control Studies Celiac disease Colorectal cancer Comorbidity Demographics Dimers Electrocardiography Embolisms Emergency medical care Emergency medical services Female Hematology Hospitals Humans Inflammation Inflammatory bowel disease Ischemia Lactates Lactic acid Length of stay Leukocytes Leukocytes (neutrophilic) Lymphocytes Male Mesenteric Ischemia - diagnosis Missing data Mortality Patients Prognosis Proteins Regression analysis Retrospective Studies Risk groups ROC Curve Serum Albumin Software Statistical analysis Thrombosis |
| title | The Prognostic Value of C-Reactive Protein/Albumin Ratio in Acute Mesenteric Ischemia |
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