Evidence against involvement of kynurenate branch of kynurenine pathway in pathophysiology of Fuchs’ dystrophy and keratoconus

Kynurenine aminotransferases (KAT) are enzymes catalyzing formation of kynurenic acid (KYNA) from kynurenine. KYNA is a Janus-faced molecule of high biological activity. On the one hand KYNA was identified as a UV filter and neuroprotectant with free radical scavenging properties, but on the other h...

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Veröffentlicht in:	Experimental eye research 2022-03, Vol.216, p.108959-108959, Article 108959
Hauptverfasser:	Matysik-Woźniak, Anna, Wnorowski, Artur, Turski, Waldemar A., Jóźwiak, Krzysztof, Rejdak, Robert, Jünemann, Anselm
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Female Fuchs' endothelial corneal dystrophy Fuchs' Endothelial Dystrophy - enzymology Fuchs' Endothelial Dystrophy - physiopathology Gene Expression Profiling Humans Immunochemistry Immunohistochemistry Keratoconus Keratoconus - enzymology Keratoconus - physiopathology Kynurenine aminotransferase Male Middle Aged Receptors, G-Protein-Coupled - metabolism Transaminase Transaminases - genetics Transaminases - metabolism
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