Effects of acute alcohol administration on working memory: a systematic review and meta-analysis
Rationale Alcohol-induced executive function deficits may underlie associations between alcohol, self-regulation, and hazardous behaviors. Studies examining the effects of alcohol administration on working memory, an important executive functioning component, have produced mixed findings. Acute alco...
Gespeichert in:
| Veröffentlicht in: | Psychopharmacology 2022-03, Vol.239 (3), p.695-708 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 708 |
|---|---|
| container_issue | 3 |
| container_start_page | 695 |
| container_title | Psychopharmacology |
| container_volume | 239 |
| creator | Spinola, Suzanne De Vita, Martin J. Gilmour, Christina E. Maisto, Stephen A. |
| description | Rationale
Alcohol-induced executive function deficits may underlie associations between alcohol, self-regulation, and hazardous behaviors. Studies examining the effects of alcohol administration on working memory, an important executive functioning component, have produced mixed findings. Acute alcohol effects on working memory remain unclear.
Objectives
We aimed to conduct a systematic review and meta-analysis on the effects of acute alcohol administration on working memory outcomes in studies of healthy adults.
Methods
We performed a systematic search of PubMed, MEDLINE, and PsycINFO from inception to June 2021. Studies were included if they met criteria, including healthy participants and administration of quantified alcohol doses against comparative controls. Data extracted included primary working memory outcomes, alcohol doses, and study characteristics. Study quality was assessed using an established validity measure. Working memory task type, alcohol dose, control condition type, and sex/gender composition were explored as moderators using mixed-effects models and meta-regressions.
Results
Thirty-two studies (1629 participants) provided sufficient data for 54 comparisons between alcohol and control conditions. Random-effects meta-analysis indicated that alcohol administration produced significant, small- to medium-sized working memory decrements (g [95% CI] = − 0.300 [− 0.390 to − 0.211],
p
|
| doi_str_mv | 10.1007/s00213-022-06060-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2622659017</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A695575014</galeid><sourcerecordid>A695575014</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-7e79996d28e01011b5deb61e178e83a739d58a36bcc0f947983008611e42cdee3</originalsourceid><addsrcrecordid>eNp9kcFO3DAQhq2qqGy3fYEekKVeejGM7ThOekOItkhIXNqz63UmW0Nig52A9u3xdikIhOqxNJLn-0fj-Qn5xOGQA-ijDCC4ZCAEg7oEU2_IgldSMAFavCULACmZ5KrZJ-9zvoRyqqZ6R_alAq0UFwvy-7Tv0U2Zxp5aN09I7eDinzhQ240--DwlO_kYaLl3MV35sKYjjjFtvlJL8yZPOBbA0YS3Hu-oDV2pT5bZYIdN9vkD2evtkPHjQ16SX99Of578YOcX389Ojs-ZqyoxMY26bdu6Ew0CB85XqsNVzZHrBhtptWw71VhZr5yDvq1020iApuYcK-E6RLkkX3Z9r1O8mTFPZvTZ4TDYgHHORtRC1KoFrgv6-QV6GedU5t1SUnHQZU1P1NoOaHzoY1mF2zY1x3WrlFZQdr0kh69QJTocvYsBe1_enwnETuBSzDlhb66TH23aGA5ma6vZ2WqKreavrUYV0cHDxPNqxO5R8s_HAsgdkEsprDE9fek_be8Bjzeq5Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2635107048</pqid></control><display><type>article</type><title>Effects of acute alcohol administration on working memory: a systematic review and meta-analysis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Spinola, Suzanne ; De Vita, Martin J. ; Gilmour, Christina E. ; Maisto, Stephen A.</creator><creatorcontrib>Spinola, Suzanne ; De Vita, Martin J. ; Gilmour, Christina E. ; Maisto, Stephen A.</creatorcontrib><description>Rationale
Alcohol-induced executive function deficits may underlie associations between alcohol, self-regulation, and hazardous behaviors. Studies examining the effects of alcohol administration on working memory, an important executive functioning component, have produced mixed findings. Acute alcohol effects on working memory remain unclear.
Objectives
We aimed to conduct a systematic review and meta-analysis on the effects of acute alcohol administration on working memory outcomes in studies of healthy adults.
Methods
We performed a systematic search of PubMed, MEDLINE, and PsycINFO from inception to June 2021. Studies were included if they met criteria, including healthy participants and administration of quantified alcohol doses against comparative controls. Data extracted included primary working memory outcomes, alcohol doses, and study characteristics. Study quality was assessed using an established validity measure. Working memory task type, alcohol dose, control condition type, and sex/gender composition were explored as moderators using mixed-effects models and meta-regressions.
Results
Thirty-two studies (1629 participants) provided sufficient data for 54 comparisons between alcohol and control conditions. Random-effects meta-analysis indicated that alcohol administration produced significant, small- to medium-sized working memory decrements (g [95% CI] = − 0.300 [− 0.390 to − 0.211],
p
< 0.001). Moderation analyses suggested that these effects differed as a function of task type, dose, control condition type, and sex/gender composition. The average quality rating across studies was good.
Conclusions
Alcohol administration significantly impaired working memory performance, particularly when executive-related manipulation processes were involved. Future research is needed to investigate how alcohol-induced working memory impairments relate to compromised self-regulation, hazardous behavior, and negative drinking consequences.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-022-06060-5</identifier><identifier>PMID: 35075512</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Alcohol ; Alcohols ; Analysis ; Biomedical and Life Sciences ; Biomedicine ; Cognition ; Dosage and administration ; Drinking behavior ; Ethanol - adverse effects ; Executive function ; Executive Function - physiology ; Gender ; Healthy Volunteers ; Humans ; Memory, Short-Term - physiology ; Mental task performance ; Meta-analysis ; Neurosciences ; Pharmacology/Toxicology ; Psychiatry ; Psychological aspects ; Review ; Short term memory ; Systematic review</subject><ispartof>Psychopharmacology, 2022-03, Vol.239 (3), p.695-708</ispartof><rights>This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2022</rights><rights>2022. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-7e79996d28e01011b5deb61e178e83a739d58a36bcc0f947983008611e42cdee3</citedby><cites>FETCH-LOGICAL-c442t-7e79996d28e01011b5deb61e178e83a739d58a36bcc0f947983008611e42cdee3</cites><orcidid>0000-0002-2361-8802</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00213-022-06060-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00213-022-06060-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35075512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spinola, Suzanne</creatorcontrib><creatorcontrib>De Vita, Martin J.</creatorcontrib><creatorcontrib>Gilmour, Christina E.</creatorcontrib><creatorcontrib>Maisto, Stephen A.</creatorcontrib><title>Effects of acute alcohol administration on working memory: a systematic review and meta-analysis</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Rationale
Alcohol-induced executive function deficits may underlie associations between alcohol, self-regulation, and hazardous behaviors. Studies examining the effects of alcohol administration on working memory, an important executive functioning component, have produced mixed findings. Acute alcohol effects on working memory remain unclear.
Objectives
We aimed to conduct a systematic review and meta-analysis on the effects of acute alcohol administration on working memory outcomes in studies of healthy adults.
Methods
We performed a systematic search of PubMed, MEDLINE, and PsycINFO from inception to June 2021. Studies were included if they met criteria, including healthy participants and administration of quantified alcohol doses against comparative controls. Data extracted included primary working memory outcomes, alcohol doses, and study characteristics. Study quality was assessed using an established validity measure. Working memory task type, alcohol dose, control condition type, and sex/gender composition were explored as moderators using mixed-effects models and meta-regressions.
Results
Thirty-two studies (1629 participants) provided sufficient data for 54 comparisons between alcohol and control conditions. Random-effects meta-analysis indicated that alcohol administration produced significant, small- to medium-sized working memory decrements (g [95% CI] = − 0.300 [− 0.390 to − 0.211],
p
< 0.001). Moderation analyses suggested that these effects differed as a function of task type, dose, control condition type, and sex/gender composition. The average quality rating across studies was good.
Conclusions
Alcohol administration significantly impaired working memory performance, particularly when executive-related manipulation processes were involved. Future research is needed to investigate how alcohol-induced working memory impairments relate to compromised self-regulation, hazardous behavior, and negative drinking consequences.</description><subject>Adult</subject><subject>Alcohol</subject><subject>Alcohols</subject><subject>Analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cognition</subject><subject>Dosage and administration</subject><subject>Drinking behavior</subject><subject>Ethanol - adverse effects</subject><subject>Executive function</subject><subject>Executive Function - physiology</subject><subject>Gender</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Memory, Short-Term - physiology</subject><subject>Mental task performance</subject><subject>Meta-analysis</subject><subject>Neurosciences</subject><subject>Pharmacology/Toxicology</subject><subject>Psychiatry</subject><subject>Psychological aspects</subject><subject>Review</subject><subject>Short term memory</subject><subject>Systematic review</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kcFO3DAQhq2qqGy3fYEekKVeejGM7ThOekOItkhIXNqz63UmW0Nig52A9u3xdikIhOqxNJLn-0fj-Qn5xOGQA-ijDCC4ZCAEg7oEU2_IgldSMAFavCULACmZ5KrZJ-9zvoRyqqZ6R_alAq0UFwvy-7Tv0U2Zxp5aN09I7eDinzhQ240--DwlO_kYaLl3MV35sKYjjjFtvlJL8yZPOBbA0YS3Hu-oDV2pT5bZYIdN9vkD2evtkPHjQ16SX99Of578YOcX389Ojs-ZqyoxMY26bdu6Ew0CB85XqsNVzZHrBhtptWw71VhZr5yDvq1020iApuYcK-E6RLkkX3Z9r1O8mTFPZvTZ4TDYgHHORtRC1KoFrgv6-QV6GedU5t1SUnHQZU1P1NoOaHzoY1mF2zY1x3WrlFZQdr0kh69QJTocvYsBe1_enwnETuBSzDlhb66TH23aGA5ma6vZ2WqKreavrUYV0cHDxPNqxO5R8s_HAsgdkEsprDE9fek_be8Bjzeq5Q</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Spinola, Suzanne</creator><creator>De Vita, Martin J.</creator><creator>Gilmour, Christina E.</creator><creator>Maisto, Stephen A.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2361-8802</orcidid></search><sort><creationdate>20220301</creationdate><title>Effects of acute alcohol administration on working memory: a systematic review and meta-analysis</title><author>Spinola, Suzanne ; De Vita, Martin J. ; Gilmour, Christina E. ; Maisto, Stephen A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-7e79996d28e01011b5deb61e178e83a739d58a36bcc0f947983008611e42cdee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Alcohol</topic><topic>Alcohols</topic><topic>Analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cognition</topic><topic>Dosage and administration</topic><topic>Drinking behavior</topic><topic>Ethanol - adverse effects</topic><topic>Executive function</topic><topic>Executive Function - physiology</topic><topic>Gender</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Memory, Short-Term - physiology</topic><topic>Mental task performance</topic><topic>Meta-analysis</topic><topic>Neurosciences</topic><topic>Pharmacology/Toxicology</topic><topic>Psychiatry</topic><topic>Psychological aspects</topic><topic>Review</topic><topic>Short term memory</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spinola, Suzanne</creatorcontrib><creatorcontrib>De Vita, Martin J.</creatorcontrib><creatorcontrib>Gilmour, Christina E.</creatorcontrib><creatorcontrib>Maisto, Stephen A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spinola, Suzanne</au><au>De Vita, Martin J.</au><au>Gilmour, Christina E.</au><au>Maisto, Stephen A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of acute alcohol administration on working memory: a systematic review and meta-analysis</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>239</volume><issue>3</issue><spage>695</spage><epage>708</epage><pages>695-708</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Rationale
Alcohol-induced executive function deficits may underlie associations between alcohol, self-regulation, and hazardous behaviors. Studies examining the effects of alcohol administration on working memory, an important executive functioning component, have produced mixed findings. Acute alcohol effects on working memory remain unclear.
Objectives
We aimed to conduct a systematic review and meta-analysis on the effects of acute alcohol administration on working memory outcomes in studies of healthy adults.
Methods
We performed a systematic search of PubMed, MEDLINE, and PsycINFO from inception to June 2021. Studies were included if they met criteria, including healthy participants and administration of quantified alcohol doses against comparative controls. Data extracted included primary working memory outcomes, alcohol doses, and study characteristics. Study quality was assessed using an established validity measure. Working memory task type, alcohol dose, control condition type, and sex/gender composition were explored as moderators using mixed-effects models and meta-regressions.
Results
Thirty-two studies (1629 participants) provided sufficient data for 54 comparisons between alcohol and control conditions. Random-effects meta-analysis indicated that alcohol administration produced significant, small- to medium-sized working memory decrements (g [95% CI] = − 0.300 [− 0.390 to − 0.211],
p
< 0.001). Moderation analyses suggested that these effects differed as a function of task type, dose, control condition type, and sex/gender composition. The average quality rating across studies was good.
Conclusions
Alcohol administration significantly impaired working memory performance, particularly when executive-related manipulation processes were involved. Future research is needed to investigate how alcohol-induced working memory impairments relate to compromised self-regulation, hazardous behavior, and negative drinking consequences.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35075512</pmid><doi>10.1007/s00213-022-06060-5</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-2361-8802</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-3158 |
| ispartof | Psychopharmacology, 2022-03, Vol.239 (3), p.695-708 |
| issn | 0033-3158 1432-2072 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2622659017 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Alcohol Alcohols Analysis Biomedical and Life Sciences Biomedicine Cognition Dosage and administration Drinking behavior Ethanol - adverse effects Executive function Executive Function - physiology Gender Healthy Volunteers Humans Memory, Short-Term - physiology Mental task performance Meta-analysis Neurosciences Pharmacology/Toxicology Psychiatry Psychological aspects Review Short term memory Systematic review |
| title | Effects of acute alcohol administration on working memory: a systematic review and meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T15%3A24%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20acute%20alcohol%20administration%20on%20working%20memory:%20a%20systematic%20review%20and%20meta-analysis&rft.jtitle=Psychopharmacology&rft.au=Spinola,%20Suzanne&rft.date=2022-03-01&rft.volume=239&rft.issue=3&rft.spage=695&rft.epage=708&rft.pages=695-708&rft.issn=0033-3158&rft.eissn=1432-2072&rft_id=info:doi/10.1007/s00213-022-06060-5&rft_dat=%3Cgale_proqu%3EA695575014%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2635107048&rft_id=info:pmid/35075512&rft_galeid=A695575014&rfr_iscdi=true |