Methyl benzoate derivatives as inhibitors of pentose phosphate pathway, which promotes cancer progression and drug resistance: An in silico study supported by in vitro results

The pentose phosphate pathway (PPP), whose products are vital in biosynthetic events, is targeted in the treatment of many diseases such as cancer and malaria. The objective of this study was to identify new PPP inhibitors. The inhibition effects of methyl 4‐amino benzoates on glucose 6‐phosphate de...

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Veröffentlicht in:	Biotechnology and applied biochemistry 2022-06, Vol.69 (3), p.1275-1283
Hauptverfasser:	Kesebir, Arzu Öztürk, Güller, Pınar, Kalın, Ramazan, Özdemir, Hasan, Küfrevioğlu, Ömer İrfan
Format:	Artikel
Sprache:	eng
Schlagworte:	6‐phosphogluconate dehydrogenase Benzoates Benzoic acid Cancer Dehydrogenase Dehydrogenases Drug development Drug resistance Glucose 6 phosphate dehydrogenase Glucosephosphate dehydrogenase inhibition Inhibitors Malaria Methyl benzoate Molecular docking Pentose Pentose phosphate pathway Phosphogluconate dehydrogenase (decarboxylating) Vector-borne diseases
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