Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region
Purpose Magnetic resonance imaging (MRI) is routinely used to evaluate spine pathology; however, standard imaging findings weakly correlate to low back pain. Abnormal disc mechanical function is implicated as a cause of back pain but is not assessed using standard clinical MRI. Our objective was to...
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| Veröffentlicht in: | European spine journal 2022-03, Vol.31 (3), p.746-754 |
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| container_title | European spine journal |
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| creator | Martin, John T. Oldweiler, Alexander B. Kosinski, Andrzej S. Spritzer, Charles E. Soher, Brian J. Erickson, Melissa M. Goode, Adam P. DeFrate, Louis E. |
| description | Purpose
Magnetic resonance imaging (MRI) is routinely used to evaluate spine pathology; however, standard imaging findings weakly correlate to low back pain. Abnormal disc mechanical function is implicated as a cause of back pain but is not assessed using standard clinical MRI. Our objective was to utilize our established MRI protocol for measuring disc function to quantify disc mechanical function in a healthy cohort.
Methods
We recruited young, asymptomatic volunteers (6 male/6 female; age 18–30 years; BMI |
| doi_str_mv | 10.1007/s00586-021-07097-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2622479340</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2622479340</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-4908f1cc85770048c5ca8946e7dd40f9ee949d2edc05ec18494bdc5ba8b1ea453</originalsourceid><addsrcrecordid>eNp9kUtr3TAQhUVpaG7S_oEuiqCbbNyM5JFlLUPICy50k66FLI9TBz9uJfvS_Pvo2kkDXWSjQcx3zsxwGPsq4IcA0OcRQJVFBlJkoMHoDD-wjcBcZmBy-ZFtwCBkhRbmmJ3E-AgglIHiEzvOFWipDW7Yfjv3lQu8HSYKewoTVcF1vG6jT88chsOHmjH0bmrHIXI31PxerkWE3yMP1Lm_S5NPbU-R71144tUTj7v2oO5oT93CL6aBHhL6mR01rov05aWesl_XV_eXt9n2583d5cU287lWU4YGykZ4XyqtAbD0yrvSYEG6rhEaQ2TQ1JJqD4q8KNFgVXtVubIS5FDlp-xs9d2F8c9McbJ9WoK6zg00ztHKQkrUJkdI6Pf_0Mdxuf9AoRQ5KhCJkivlwxhjoMbuQtuni60Ae0jFrqnYlIpdUrGYRN9erOeqp_qf5DWGBOQrEFNreKDwNvsd22epi5iA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2642134501</pqid></control><display><type>article</type><title>Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Martin, John T. ; Oldweiler, Alexander B. ; Kosinski, Andrzej S. ; Spritzer, Charles E. ; Soher, Brian J. ; Erickson, Melissa M. ; Goode, Adam P. ; DeFrate, Louis E.</creator><creatorcontrib>Martin, John T. ; Oldweiler, Alexander B. ; Kosinski, Andrzej S. ; Spritzer, Charles E. ; Soher, Brian J. ; Erickson, Melissa M. ; Goode, Adam P. ; DeFrate, Louis E.</creatorcontrib><description>Purpose
Magnetic resonance imaging (MRI) is routinely used to evaluate spine pathology; however, standard imaging findings weakly correlate to low back pain. Abnormal disc mechanical function is implicated as a cause of back pain but is not assessed using standard clinical MRI. Our objective was to utilize our established MRI protocol for measuring disc function to quantify disc mechanical function in a healthy cohort.
Methods
We recruited young, asymptomatic volunteers (6 male/6 female; age 18–30 years; BMI < 30) and used MRI to determine how diurnal deformations in disc height, volume, and perimeter were affected by spinal level, disc region, MRI biomarkers of disc health (T2, T1rho), and Pfirrmann grade.
Results
Lumbar discs deformed by a mean of −6.1% (95% CI: −7.6%, −4.7%) to −8.0% (CI: −10.6%, −5.4%) in height and −5.4% (CI: −7.6%, −3.3%) to −8.5% (CI: −11.0%, −6.0%) in volume from AM to PM across spinal levels. Regional deformations were more uniform in cranial lumbar levels and concentrated posteriorly in the caudal levels, reaching a maximum of 13.1% at L5–S1 (CI:−16.1%, −10.2%). T2 and T1rho relaxation times were greatest in the nucleus and varied circumferentially within the annulus. T2 relaxation times were greatest at the most cranial spinal levels and decreased caudally. In this young healthy cohort, we identified a weak association between nucleus T2 and the diurnal change in the perimeter.
Conclusions
Spinal level is a key factor in determining regional disc deformations. Interestingly, deformations were concentrated in the posterior regions of caudal discs where disc herniation is most prevalent.</description><identifier>ISSN: 0940-6719</identifier><identifier>EISSN: 1432-0932</identifier><identifier>DOI: 10.1007/s00586-021-07097-4</identifier><identifier>PMID: 35072794</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Back pain ; Diurnal ; Female ; Humans ; Intervertebral Disc - diagnostic imaging ; Intervertebral Disc - pathology ; Intervertebral Disc Degeneration - pathology ; Intervertebral Disc Displacement - complications ; Intervertebral discs ; Low back pain ; Low Back Pain - etiology ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - pathology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Mechanical properties ; Medicine ; Medicine & Public Health ; Neurosurgery ; Original Article ; Skull ; Spine (lumbar) ; Surgical Orthopedics ; Young Adult</subject><ispartof>European spine journal, 2022-03, Vol.31 (3), p.746-754</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-4908f1cc85770048c5ca8946e7dd40f9ee949d2edc05ec18494bdc5ba8b1ea453</citedby><cites>FETCH-LOGICAL-c375t-4908f1cc85770048c5ca8946e7dd40f9ee949d2edc05ec18494bdc5ba8b1ea453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00586-021-07097-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00586-021-07097-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35072794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin, John T.</creatorcontrib><creatorcontrib>Oldweiler, Alexander B.</creatorcontrib><creatorcontrib>Kosinski, Andrzej S.</creatorcontrib><creatorcontrib>Spritzer, Charles E.</creatorcontrib><creatorcontrib>Soher, Brian J.</creatorcontrib><creatorcontrib>Erickson, Melissa M.</creatorcontrib><creatorcontrib>Goode, Adam P.</creatorcontrib><creatorcontrib>DeFrate, Louis E.</creatorcontrib><title>Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region</title><title>European spine journal</title><addtitle>Eur Spine J</addtitle><addtitle>Eur Spine J</addtitle><description>Purpose
Magnetic resonance imaging (MRI) is routinely used to evaluate spine pathology; however, standard imaging findings weakly correlate to low back pain. Abnormal disc mechanical function is implicated as a cause of back pain but is not assessed using standard clinical MRI. Our objective was to utilize our established MRI protocol for measuring disc function to quantify disc mechanical function in a healthy cohort.
Methods
We recruited young, asymptomatic volunteers (6 male/6 female; age 18–30 years; BMI < 30) and used MRI to determine how diurnal deformations in disc height, volume, and perimeter were affected by spinal level, disc region, MRI biomarkers of disc health (T2, T1rho), and Pfirrmann grade.
Results
Lumbar discs deformed by a mean of −6.1% (95% CI: −7.6%, −4.7%) to −8.0% (CI: −10.6%, −5.4%) in height and −5.4% (CI: −7.6%, −3.3%) to −8.5% (CI: −11.0%, −6.0%) in volume from AM to PM across spinal levels. Regional deformations were more uniform in cranial lumbar levels and concentrated posteriorly in the caudal levels, reaching a maximum of 13.1% at L5–S1 (CI:−16.1%, −10.2%). T2 and T1rho relaxation times were greatest in the nucleus and varied circumferentially within the annulus. T2 relaxation times were greatest at the most cranial spinal levels and decreased caudally. In this young healthy cohort, we identified a weak association between nucleus T2 and the diurnal change in the perimeter.
Conclusions
Spinal level is a key factor in determining regional disc deformations. Interestingly, deformations were concentrated in the posterior regions of caudal discs where disc herniation is most prevalent.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Back pain</subject><subject>Diurnal</subject><subject>Female</subject><subject>Humans</subject><subject>Intervertebral Disc - diagnostic imaging</subject><subject>Intervertebral Disc - pathology</subject><subject>Intervertebral Disc Degeneration - pathology</subject><subject>Intervertebral Disc Displacement - complications</subject><subject>Intervertebral discs</subject><subject>Low back pain</subject><subject>Low Back Pain - etiology</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Mechanical properties</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Skull</subject><subject>Spine (lumbar)</subject><subject>Surgical Orthopedics</subject><subject>Young Adult</subject><issn>0940-6719</issn><issn>1432-0932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtr3TAQhUVpaG7S_oEuiqCbbNyM5JFlLUPICy50k66FLI9TBz9uJfvS_Pvo2kkDXWSjQcx3zsxwGPsq4IcA0OcRQJVFBlJkoMHoDD-wjcBcZmBy-ZFtwCBkhRbmmJ3E-AgglIHiEzvOFWipDW7Yfjv3lQu8HSYKewoTVcF1vG6jT88chsOHmjH0bmrHIXI31PxerkWE3yMP1Lm_S5NPbU-R71144tUTj7v2oO5oT93CL6aBHhL6mR01rov05aWesl_XV_eXt9n2583d5cU287lWU4YGykZ4XyqtAbD0yrvSYEG6rhEaQ2TQ1JJqD4q8KNFgVXtVubIS5FDlp-xs9d2F8c9McbJ9WoK6zg00ztHKQkrUJkdI6Pf_0Mdxuf9AoRQ5KhCJkivlwxhjoMbuQtuni60Ae0jFrqnYlIpdUrGYRN9erOeqp_qf5DWGBOQrEFNreKDwNvsd22epi5iA</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Martin, John T.</creator><creator>Oldweiler, Alexander B.</creator><creator>Kosinski, Andrzej S.</creator><creator>Spritzer, Charles E.</creator><creator>Soher, Brian J.</creator><creator>Erickson, Melissa M.</creator><creator>Goode, Adam P.</creator><creator>DeFrate, Louis E.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20220301</creationdate><title>Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region</title><author>Martin, John T. ; Oldweiler, Alexander B. ; Kosinski, Andrzej S. ; Spritzer, Charles E. ; Soher, Brian J. ; Erickson, Melissa M. ; Goode, Adam P. ; DeFrate, Louis E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-4908f1cc85770048c5ca8946e7dd40f9ee949d2edc05ec18494bdc5ba8b1ea453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Back pain</topic><topic>Diurnal</topic><topic>Female</topic><topic>Humans</topic><topic>Intervertebral Disc - diagnostic imaging</topic><topic>Intervertebral Disc - pathology</topic><topic>Intervertebral Disc Degeneration - pathology</topic><topic>Intervertebral Disc Displacement - complications</topic><topic>Intervertebral discs</topic><topic>Low back pain</topic><topic>Low Back Pain - etiology</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Mechanical properties</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Skull</topic><topic>Spine (lumbar)</topic><topic>Surgical Orthopedics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin, John T.</creatorcontrib><creatorcontrib>Oldweiler, Alexander B.</creatorcontrib><creatorcontrib>Kosinski, Andrzej S.</creatorcontrib><creatorcontrib>Spritzer, Charles E.</creatorcontrib><creatorcontrib>Soher, Brian J.</creatorcontrib><creatorcontrib>Erickson, Melissa M.</creatorcontrib><creatorcontrib>Goode, Adam P.</creatorcontrib><creatorcontrib>DeFrate, Louis E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European spine journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin, John T.</au><au>Oldweiler, Alexander B.</au><au>Kosinski, Andrzej S.</au><au>Spritzer, Charles E.</au><au>Soher, Brian J.</au><au>Erickson, Melissa M.</au><au>Goode, Adam P.</au><au>DeFrate, Louis E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region</atitle><jtitle>European spine journal</jtitle><stitle>Eur Spine J</stitle><addtitle>Eur Spine J</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>31</volume><issue>3</issue><spage>746</spage><epage>754</epage><pages>746-754</pages><issn>0940-6719</issn><eissn>1432-0932</eissn><abstract>Purpose
Magnetic resonance imaging (MRI) is routinely used to evaluate spine pathology; however, standard imaging findings weakly correlate to low back pain. Abnormal disc mechanical function is implicated as a cause of back pain but is not assessed using standard clinical MRI. Our objective was to utilize our established MRI protocol for measuring disc function to quantify disc mechanical function in a healthy cohort.
Methods
We recruited young, asymptomatic volunteers (6 male/6 female; age 18–30 years; BMI < 30) and used MRI to determine how diurnal deformations in disc height, volume, and perimeter were affected by spinal level, disc region, MRI biomarkers of disc health (T2, T1rho), and Pfirrmann grade.
Results
Lumbar discs deformed by a mean of −6.1% (95% CI: −7.6%, −4.7%) to −8.0% (CI: −10.6%, −5.4%) in height and −5.4% (CI: −7.6%, −3.3%) to −8.5% (CI: −11.0%, −6.0%) in volume from AM to PM across spinal levels. Regional deformations were more uniform in cranial lumbar levels and concentrated posteriorly in the caudal levels, reaching a maximum of 13.1% at L5–S1 (CI:−16.1%, −10.2%). T2 and T1rho relaxation times were greatest in the nucleus and varied circumferentially within the annulus. T2 relaxation times were greatest at the most cranial spinal levels and decreased caudally. In this young healthy cohort, we identified a weak association between nucleus T2 and the diurnal change in the perimeter.
Conclusions
Spinal level is a key factor in determining regional disc deformations. Interestingly, deformations were concentrated in the posterior regions of caudal discs where disc herniation is most prevalent.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35072794</pmid><doi>10.1007/s00586-021-07097-4</doi><tpages>9</tpages></addata></record> |
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| ispartof | European spine journal, 2022-03, Vol.31 (3), p.746-754 |
| issn | 0940-6719 1432-0932 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Back pain Diurnal Female Humans Intervertebral Disc - diagnostic imaging Intervertebral Disc - pathology Intervertebral Disc Degeneration - pathology Intervertebral Disc Displacement - complications Intervertebral discs Low back pain Low Back Pain - etiology Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - pathology Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Mechanical properties Medicine Medicine & Public Health Neurosurgery Original Article Skull Spine (lumbar) Surgical Orthopedics Young Adult |
| title | Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region |
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