Prognostic value of circulating tumor cells and its association with the expression of cancer stem cells in nasopharyngeal carcinoma patients
The release of circulating tumor cells (CTCs) into vasculature is an early event in the metastatic process and the detection of CTCs has been widely used clinically. In addition, cancer stem cells (CSCs) are the source of distant metastasis. However, the relationship between CTCs and CSCs in nasopha...
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| Veröffentlicht in: | Neoplasma 2022-03, Vol.69 (2), p.303-310 |
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| creator | Lu, Lin Huang, Hao-Wei Du, Huan Liu, Zhi-Xiang Zha, Zhi-Qiang Wang, Pei-Pei Wu, Yong Liu, Xia Weng, Cheng-Yin Fang, Xi-Sheng Li, Bao-Xiu Mao, Hai-Bo Wang, Li-Na Wang, Xiao-Pai Guan, Ming-Mei Liu, Guo-Long |
| description | The release of circulating tumor cells (CTCs) into vasculature is an early event in the metastatic process and the detection of CTCs has been widely used clinically. In addition, cancer stem cells (CSCs) are the source of distant metastasis. However, the relationship between CTCs and CSCs in nasopharyngeal carcinoma (NPC) patients was largely unknown. A total of 93 NPC patients were enrolled in this study. The CTCs in the peripheral blood were detected. The expression of ALDH1A1 in the tumor tissues of the corresponding patients was detected using immunohistochemistry (IHC). The prognostic value of CTCs level and the correlation with the expression of ALDH1A1 was evaluated. Data showed that the detection of CTCs was positively correlated with metastasis (p |
| doi_str_mv | 10.4149/neo_2021_210707N906 |
| format | Article |
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In addition, cancer stem cells (CSCs) are the source of distant metastasis. However, the relationship between CTCs and CSCs in nasopharyngeal carcinoma (NPC) patients was largely unknown. A total of 93 NPC patients were enrolled in this study. The CTCs in the peripheral blood were detected. The expression of ALDH1A1 in the tumor tissues of the corresponding patients was detected using immunohistochemistry (IHC). The prognostic value of CTCs level and the correlation with the expression of ALDH1A1 was evaluated. Data showed that the detection of CTCs was positively correlated with metastasis (p<0.001). The positive detection of CTCs was also associated with poor overall survival (p=0.025). CTCs ≥2 demonstrated good specificity and sensitivity in predicting distant metastasis, while CTCs ≥8 demonstrated better specificity and sensitivity in predicting prognosis than CTCs ≥2. Furthermore, we found that there was a positive relationship between the detection of CTCs and the expression of ALDH1A1 (p=0.001). The prognosis analysis also demonstrated that high ALDH1A1 expression was correlated with poor overall survival (p=0.006). Our study demonstrated a positive correlation between the CTCs and the expression of CSCs, both were positively correlated with metastasis and poor prognosis. These results indicated that the CTCs might indirectly reflect the expression of CSCs.</description><identifier>ISSN: 0028-2685</identifier><identifier>ISSN: 1338-4317</identifier><identifier>EISSN: 1338-4317</identifier><identifier>DOI: 10.4149/neo_2021_210707N906</identifier><identifier>PMID: 35068161</identifier><language>eng</language><publisher>Slovakia</publisher><subject>Biomarkers, Tumor - metabolism ; Humans ; Nasopharyngeal Carcinoma - diagnosis ; Nasopharyngeal Neoplasms - pathology ; Neoplastic Cells, Circulating - metabolism ; Neoplastic Stem Cells - pathology ; Prognosis</subject><ispartof>Neoplasma, 2022-03, Vol.69 (2), p.303-310</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-e9229036c071532195fe367d8f456f5d37994dee758dcdc7425d74388e6dbd073</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35068161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Lin</creatorcontrib><creatorcontrib>Huang, Hao-Wei</creatorcontrib><creatorcontrib>Du, Huan</creatorcontrib><creatorcontrib>Liu, Zhi-Xiang</creatorcontrib><creatorcontrib>Zha, Zhi-Qiang</creatorcontrib><creatorcontrib>Wang, Pei-Pei</creatorcontrib><creatorcontrib>Wu, Yong</creatorcontrib><creatorcontrib>Liu, Xia</creatorcontrib><creatorcontrib>Weng, Cheng-Yin</creatorcontrib><creatorcontrib>Fang, Xi-Sheng</creatorcontrib><creatorcontrib>Li, Bao-Xiu</creatorcontrib><creatorcontrib>Mao, Hai-Bo</creatorcontrib><creatorcontrib>Wang, Li-Na</creatorcontrib><creatorcontrib>Wang, Xiao-Pai</creatorcontrib><creatorcontrib>Guan, Ming-Mei</creatorcontrib><creatorcontrib>Liu, Guo-Long</creatorcontrib><title>Prognostic value of circulating tumor cells and its association with the expression of cancer stem cells in nasopharyngeal carcinoma patients</title><title>Neoplasma</title><addtitle>Neoplasma</addtitle><description>The release of circulating tumor cells (CTCs) into vasculature is an early event in the metastatic process and the detection of CTCs has been widely used clinically. In addition, cancer stem cells (CSCs) are the source of distant metastasis. However, the relationship between CTCs and CSCs in nasopharyngeal carcinoma (NPC) patients was largely unknown. A total of 93 NPC patients were enrolled in this study. The CTCs in the peripheral blood were detected. The expression of ALDH1A1 in the tumor tissues of the corresponding patients was detected using immunohistochemistry (IHC). The prognostic value of CTCs level and the correlation with the expression of ALDH1A1 was evaluated. Data showed that the detection of CTCs was positively correlated with metastasis (p<0.001). The positive detection of CTCs was also associated with poor overall survival (p=0.025). CTCs ≥2 demonstrated good specificity and sensitivity in predicting distant metastasis, while CTCs ≥8 demonstrated better specificity and sensitivity in predicting prognosis than CTCs ≥2. Furthermore, we found that there was a positive relationship between the detection of CTCs and the expression of ALDH1A1 (p=0.001). The prognosis analysis also demonstrated that high ALDH1A1 expression was correlated with poor overall survival (p=0.006). Our study demonstrated a positive correlation between the CTCs and the expression of CSCs, both were positively correlated with metastasis and poor prognosis. These results indicated that the CTCs might indirectly reflect the expression of CSCs.</description><subject>Biomarkers, Tumor - metabolism</subject><subject>Humans</subject><subject>Nasopharyngeal Carcinoma - diagnosis</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Neoplastic Cells, Circulating - metabolism</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>Prognosis</subject><issn>0028-2685</issn><issn>1338-4317</issn><issn>1338-4317</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptUctuFTEMjRCIXpV-QSWUJZuBPCaPWaKKl1RRFnQ9ShPPvUEzyRBneHxE_7m56oVVvbFkn3N8bBNyydnbnvfDuwR5FEzwUXBmmPk6MP2M7LiUtuslN8_JjjFhO6GtOiMXiD9YC62YEPwlOZOKacs135H7byXvU8YaPf3l5g1onqiPxW-zqzHtad2WXKiHeUbqUqCxtoyYfWz9nOjvWA-0HoDCn7UA4rF2lHDJQ6FYYTmRY6LJYV4PrvxNe3BzwxQfU14cXZsWpIqvyIvJzQgXp3xObj9--H71ubu--fTl6v1155vz2sEgxMCk9sxwJQUf1ARSm2CnXulJBWmGoQ8ARtnggze9UMH00lrQ4S4wI8_Jm0fdteSfG2Adl4hHm67ddcNRaCF6Y5lQDSofob5kxALTuJa4tB1GzsbjK8YnXtFYr08DtrsFwn_Ov8PLB0eEiBg</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Lu, Lin</creator><creator>Huang, Hao-Wei</creator><creator>Du, Huan</creator><creator>Liu, Zhi-Xiang</creator><creator>Zha, Zhi-Qiang</creator><creator>Wang, Pei-Pei</creator><creator>Wu, Yong</creator><creator>Liu, Xia</creator><creator>Weng, Cheng-Yin</creator><creator>Fang, Xi-Sheng</creator><creator>Li, Bao-Xiu</creator><creator>Mao, Hai-Bo</creator><creator>Wang, Li-Na</creator><creator>Wang, Xiao-Pai</creator><creator>Guan, Ming-Mei</creator><creator>Liu, Guo-Long</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220301</creationdate><title>Prognostic value of circulating tumor cells and its association with the expression of cancer stem cells in nasopharyngeal carcinoma patients</title><author>Lu, Lin ; Huang, Hao-Wei ; Du, Huan ; Liu, Zhi-Xiang ; Zha, Zhi-Qiang ; Wang, Pei-Pei ; Wu, Yong ; Liu, Xia ; Weng, Cheng-Yin ; Fang, Xi-Sheng ; Li, Bao-Xiu ; Mao, Hai-Bo ; Wang, Li-Na ; Wang, Xiao-Pai ; Guan, Ming-Mei ; Liu, Guo-Long</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-e9229036c071532195fe367d8f456f5d37994dee758dcdc7425d74388e6dbd073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biomarkers, Tumor - metabolism</topic><topic>Humans</topic><topic>Nasopharyngeal Carcinoma - diagnosis</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Neoplastic Cells, Circulating - metabolism</topic><topic>Neoplastic Stem Cells - pathology</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Lin</creatorcontrib><creatorcontrib>Huang, Hao-Wei</creatorcontrib><creatorcontrib>Du, Huan</creatorcontrib><creatorcontrib>Liu, Zhi-Xiang</creatorcontrib><creatorcontrib>Zha, Zhi-Qiang</creatorcontrib><creatorcontrib>Wang, Pei-Pei</creatorcontrib><creatorcontrib>Wu, Yong</creatorcontrib><creatorcontrib>Liu, Xia</creatorcontrib><creatorcontrib>Weng, Cheng-Yin</creatorcontrib><creatorcontrib>Fang, Xi-Sheng</creatorcontrib><creatorcontrib>Li, Bao-Xiu</creatorcontrib><creatorcontrib>Mao, Hai-Bo</creatorcontrib><creatorcontrib>Wang, Li-Na</creatorcontrib><creatorcontrib>Wang, Xiao-Pai</creatorcontrib><creatorcontrib>Guan, Ming-Mei</creatorcontrib><creatorcontrib>Liu, Guo-Long</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neoplasma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Lin</au><au>Huang, Hao-Wei</au><au>Du, Huan</au><au>Liu, Zhi-Xiang</au><au>Zha, Zhi-Qiang</au><au>Wang, Pei-Pei</au><au>Wu, Yong</au><au>Liu, Xia</au><au>Weng, Cheng-Yin</au><au>Fang, Xi-Sheng</au><au>Li, Bao-Xiu</au><au>Mao, Hai-Bo</au><au>Wang, Li-Na</au><au>Wang, Xiao-Pai</au><au>Guan, Ming-Mei</au><au>Liu, Guo-Long</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of circulating tumor cells and its association with the expression of cancer stem cells in nasopharyngeal carcinoma patients</atitle><jtitle>Neoplasma</jtitle><addtitle>Neoplasma</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>69</volume><issue>2</issue><spage>303</spage><epage>310</epage><pages>303-310</pages><issn>0028-2685</issn><issn>1338-4317</issn><eissn>1338-4317</eissn><abstract>The release of circulating tumor cells (CTCs) into vasculature is an early event in the metastatic process and the detection of CTCs has been widely used clinically. In addition, cancer stem cells (CSCs) are the source of distant metastasis. However, the relationship between CTCs and CSCs in nasopharyngeal carcinoma (NPC) patients was largely unknown. A total of 93 NPC patients were enrolled in this study. The CTCs in the peripheral blood were detected. The expression of ALDH1A1 in the tumor tissues of the corresponding patients was detected using immunohistochemistry (IHC). The prognostic value of CTCs level and the correlation with the expression of ALDH1A1 was evaluated. Data showed that the detection of CTCs was positively correlated with metastasis (p<0.001). The positive detection of CTCs was also associated with poor overall survival (p=0.025). CTCs ≥2 demonstrated good specificity and sensitivity in predicting distant metastasis, while CTCs ≥8 demonstrated better specificity and sensitivity in predicting prognosis than CTCs ≥2. Furthermore, we found that there was a positive relationship between the detection of CTCs and the expression of ALDH1A1 (p=0.001). The prognosis analysis also demonstrated that high ALDH1A1 expression was correlated with poor overall survival (p=0.006). Our study demonstrated a positive correlation between the CTCs and the expression of CSCs, both were positively correlated with metastasis and poor prognosis. These results indicated that the CTCs might indirectly reflect the expression of CSCs.</abstract><cop>Slovakia</cop><pmid>35068161</pmid><doi>10.4149/neo_2021_210707N906</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers, Tumor - metabolism Humans Nasopharyngeal Carcinoma - diagnosis Nasopharyngeal Neoplasms - pathology Neoplastic Cells, Circulating - metabolism Neoplastic Stem Cells - pathology Prognosis |
| title | Prognostic value of circulating tumor cells and its association with the expression of cancer stem cells in nasopharyngeal carcinoma patients |
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