The mediating role of coagulation function on the association of prenatal exposure to aflatoxin B1 and postpartum hemorrhage in Guangxi, China
Pregnant women are vulnerable to certain environmental agents, one of which is aflatoxin. As one of the most popular aflatoxins, Aflatoxin B1 (AFB1) has recently garnered increased attention concerning its potential association between exposure and adverse pregnancy outcomes. The aims of the study w...
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| Veröffentlicht in: | Environmental science and pollution research international 2022-05, Vol.29 (25), p.37543-37555 |
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| creator | Chen, Jiehua Ye, Ye Huang, Dongping Pan, Dongxiang Qiu, Xiaoqiang Lei, Lei Luo, Xingxi Li, Jinxiu Wu, Kaili Xiao, Suyang Liu, Shun Zeng, Xiaoyun |
| description | Pregnant women are vulnerable to certain environmental agents, one of which is aflatoxin. As one of the most popular aflatoxins, Aflatoxin B1 (AFB1) has recently garnered increased attention concerning its potential association between exposure and adverse pregnancy outcomes. The aims of the study were to examine the associations between prenatal exposure to AFB1 and postpartum hemorrhage (PPH), and whether coagulation function has a mediating effect on their relationship. A total of 379 mother-infant pairs were included in the present study. Prenatal serum AFB1 albumin (AFB1-Alb) adduct levels in peripheral venous blood were detected by using an ELISA kit. Multiple linear and logistics regression models were applied to analyze the relationship between AFB1-Alb levels and PPH. We found mothers with high levels of AFB1-Alb adduct levels had significantly increased postpartum blood loss (partial regression coefficient (β) = 50.71, 95% confidence interval (CI) 3.48, 97.95). Mothers with high levels of AFB1-Alb adduct levels also had significantly increased risk of PPH (odds ratio (OR) = 4.81, 95% CI 1.01, 22.98). Moreover, concentrations of AFB1-Alb were positively associated with activated partial thromboplastin time (APTT) while negatively associated with fibrinogen (FIB). One-unit increase in APTT was correlated with a 6.62-ml (95% CI 3.04, 10.20) increase in postpartum blood loss. Mediation analysis suggested that the maternal blood APTT levels had a positive mediating effect in the association between AFB1-Alb adduct levels and postpartum blood loss (β = 0.32, 95% CI 0.04, 0.68). These results indicated that prenatal exposure to AFB1 was associated with increased postpartum blood loss, possibly by interfering with maternal APTT levels. |
| doi_str_mv | 10.1007/s11356-021-18186-8 |
| format | Article |
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As one of the most popular aflatoxins, Aflatoxin B1 (AFB1) has recently garnered increased attention concerning its potential association between exposure and adverse pregnancy outcomes. The aims of the study were to examine the associations between prenatal exposure to AFB1 and postpartum hemorrhage (PPH), and whether coagulation function has a mediating effect on their relationship. A total of 379 mother-infant pairs were included in the present study. Prenatal serum AFB1 albumin (AFB1-Alb) adduct levels in peripheral venous blood were detected by using an ELISA kit. Multiple linear and logistics regression models were applied to analyze the relationship between AFB1-Alb levels and PPH. We found mothers with high levels of AFB1-Alb adduct levels had significantly increased postpartum blood loss (partial regression coefficient (β) = 50.71, 95% confidence interval (CI) 3.48, 97.95). Mothers with high levels of AFB1-Alb adduct levels also had significantly increased risk of PPH (odds ratio (OR) = 4.81, 95% CI 1.01, 22.98). Moreover, concentrations of AFB1-Alb were positively associated with activated partial thromboplastin time (APTT) while negatively associated with fibrinogen (FIB). One-unit increase in APTT was correlated with a 6.62-ml (95% CI 3.04, 10.20) increase in postpartum blood loss. Mediation analysis suggested that the maternal blood APTT levels had a positive mediating effect in the association between AFB1-Alb adduct levels and postpartum blood loss (β = 0.32, 95% CI 0.04, 0.68). These results indicated that prenatal exposure to AFB1 was associated with increased postpartum blood loss, possibly by interfering with maternal APTT levels.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-021-18186-8</identifier><identifier>PMID: 35066843</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aflatoxin B1 ; Aflatoxins ; Albumins ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Birth weight ; Blood ; Blood levels ; Coagulation ; Confidence intervals ; Earth and Environmental Science ; Ecotoxicology ; Electronic health records ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Exposure ; Fibrinogen ; Gestational age ; Hemorrhage ; Hypertension ; Logistics ; Medical records ; Mothers ; Postpartum ; Postpartum period ; Pregnancy ; Prenatal experience ; Prenatal exposure ; Public health ; Regression analysis ; Regression coefficients ; Regression models ; Research Article ; Statistical analysis ; Thromboplastin ; Waste Water Technology ; Water Management ; Water Pollution Control ; Womens health</subject><ispartof>Environmental science and pollution research international, 2022-05, Vol.29 (25), p.37543-37555</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-41130cf1e155589ddb044dfcc2088600515aa74762153fb01abce7538965106f3</citedby><cites>FETCH-LOGICAL-c375t-41130cf1e155589ddb044dfcc2088600515aa74762153fb01abce7538965106f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-021-18186-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-021-18186-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35066843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Jiehua</creatorcontrib><creatorcontrib>Ye, Ye</creatorcontrib><creatorcontrib>Huang, Dongping</creatorcontrib><creatorcontrib>Pan, Dongxiang</creatorcontrib><creatorcontrib>Qiu, Xiaoqiang</creatorcontrib><creatorcontrib>Lei, Lei</creatorcontrib><creatorcontrib>Luo, Xingxi</creatorcontrib><creatorcontrib>Li, Jinxiu</creatorcontrib><creatorcontrib>Wu, Kaili</creatorcontrib><creatorcontrib>Xiao, Suyang</creatorcontrib><creatorcontrib>Liu, Shun</creatorcontrib><creatorcontrib>Zeng, Xiaoyun</creatorcontrib><title>The mediating role of coagulation function on the association of prenatal exposure to aflatoxin B1 and postpartum hemorrhage in Guangxi, China</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Pregnant women are vulnerable to certain environmental agents, one of which is aflatoxin. As one of the most popular aflatoxins, Aflatoxin B1 (AFB1) has recently garnered increased attention concerning its potential association between exposure and adverse pregnancy outcomes. The aims of the study were to examine the associations between prenatal exposure to AFB1 and postpartum hemorrhage (PPH), and whether coagulation function has a mediating effect on their relationship. A total of 379 mother-infant pairs were included in the present study. Prenatal serum AFB1 albumin (AFB1-Alb) adduct levels in peripheral venous blood were detected by using an ELISA kit. Multiple linear and logistics regression models were applied to analyze the relationship between AFB1-Alb levels and PPH. We found mothers with high levels of AFB1-Alb adduct levels had significantly increased postpartum blood loss (partial regression coefficient (β) = 50.71, 95% confidence interval (CI) 3.48, 97.95). Mothers with high levels of AFB1-Alb adduct levels also had significantly increased risk of PPH (odds ratio (OR) = 4.81, 95% CI 1.01, 22.98). Moreover, concentrations of AFB1-Alb were positively associated with activated partial thromboplastin time (APTT) while negatively associated with fibrinogen (FIB). One-unit increase in APTT was correlated with a 6.62-ml (95% CI 3.04, 10.20) increase in postpartum blood loss. Mediation analysis suggested that the maternal blood APTT levels had a positive mediating effect in the association between AFB1-Alb adduct levels and postpartum blood loss (β = 0.32, 95% CI 0.04, 0.68). These results indicated that prenatal exposure to AFB1 was associated with increased postpartum blood loss, possibly by interfering with maternal APTT levels.</description><subject>Aflatoxin B1</subject><subject>Aflatoxins</subject><subject>Albumins</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Birth weight</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Coagulation</subject><subject>Confidence intervals</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Electronic health records</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Exposure</subject><subject>Fibrinogen</subject><subject>Gestational age</subject><subject>Hemorrhage</subject><subject>Hypertension</subject><subject>Logistics</subject><subject>Medical records</subject><subject>Mothers</subject><subject>Postpartum</subject><subject>Postpartum period</subject><subject>Pregnancy</subject><subject>Prenatal experience</subject><subject>Prenatal exposure</subject><subject>Public health</subject><subject>Regression analysis</subject><subject>Regression coefficients</subject><subject>Regression models</subject><subject>Research Article</subject><subject>Statistical analysis</subject><subject>Thromboplastin</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><subject>Womens 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mediating role of coagulation function on the association of prenatal exposure to aflatoxin B1 and postpartum hemorrhage in Guangxi, China</title><author>Chen, Jiehua ; Ye, Ye ; Huang, Dongping ; Pan, Dongxiang ; Qiu, Xiaoqiang ; Lei, Lei ; Luo, Xingxi ; Li, Jinxiu ; Wu, Kaili ; Xiao, Suyang ; Liu, Shun ; Zeng, Xiaoyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-41130cf1e155589ddb044dfcc2088600515aa74762153fb01abce7538965106f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aflatoxin B1</topic><topic>Aflatoxins</topic><topic>Albumins</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Birth weight</topic><topic>Blood</topic><topic>Blood levels</topic><topic>Coagulation</topic><topic>Confidence intervals</topic><topic>Earth and Environmental 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international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jiehua</au><au>Ye, Ye</au><au>Huang, Dongping</au><au>Pan, Dongxiang</au><au>Qiu, Xiaoqiang</au><au>Lei, Lei</au><au>Luo, Xingxi</au><au>Li, Jinxiu</au><au>Wu, Kaili</au><au>Xiao, Suyang</au><au>Liu, Shun</au><au>Zeng, Xiaoyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The mediating role of coagulation function on the association of prenatal exposure to aflatoxin B1 and postpartum hemorrhage in Guangxi, China</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>29</volume><issue>25</issue><spage>37543</spage><epage>37555</epage><pages>37543-37555</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Pregnant women are vulnerable to certain environmental agents, one of which is aflatoxin. As one of the most popular aflatoxins, Aflatoxin B1 (AFB1) has recently garnered increased attention concerning its potential association between exposure and adverse pregnancy outcomes. The aims of the study were to examine the associations between prenatal exposure to AFB1 and postpartum hemorrhage (PPH), and whether coagulation function has a mediating effect on their relationship. A total of 379 mother-infant pairs were included in the present study. Prenatal serum AFB1 albumin (AFB1-Alb) adduct levels in peripheral venous blood were detected by using an ELISA kit. Multiple linear and logistics regression models were applied to analyze the relationship between AFB1-Alb levels and PPH. We found mothers with high levels of AFB1-Alb adduct levels had significantly increased postpartum blood loss (partial regression coefficient (β) = 50.71, 95% confidence interval (CI) 3.48, 97.95). Mothers with high levels of AFB1-Alb adduct levels also had significantly increased risk of PPH (odds ratio (OR) = 4.81, 95% CI 1.01, 22.98). Moreover, concentrations of AFB1-Alb were positively associated with activated partial thromboplastin time (APTT) while negatively associated with fibrinogen (FIB). One-unit increase in APTT was correlated with a 6.62-ml (95% CI 3.04, 10.20) increase in postpartum blood loss. Mediation analysis suggested that the maternal blood APTT levels had a positive mediating effect in the association between AFB1-Alb adduct levels and postpartum blood loss (β = 0.32, 95% CI 0.04, 0.68). These results indicated that prenatal exposure to AFB1 was associated with increased postpartum blood loss, possibly by interfering with maternal APTT levels.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35066843</pmid><doi>10.1007/s11356-021-18186-8</doi><tpages>13</tpages></addata></record> |
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| subjects | Aflatoxin B1 Aflatoxins Albumins Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Birth weight Blood Blood levels Coagulation Confidence intervals Earth and Environmental Science Ecotoxicology Electronic health records Environment Environmental Chemistry Environmental Health Environmental science Exposure Fibrinogen Gestational age Hemorrhage Hypertension Logistics Medical records Mothers Postpartum Postpartum period Pregnancy Prenatal experience Prenatal exposure Public health Regression analysis Regression coefficients Regression models Research Article Statistical analysis Thromboplastin Waste Water Technology Water Management Water Pollution Control Womens health |
| title | The mediating role of coagulation function on the association of prenatal exposure to aflatoxin B1 and postpartum hemorrhage in Guangxi, China |
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