The significance of the SDF-1/CXCR4 signaling pathway in the normal development
Chemokines are chemoattractants that can regulate cell movement and adhesion. SDF-1 [stromal cell-derived factor-1 (SDF-1)] is a homeostatic CXC chemokine. SDF-1 and its receptors [CXC chemokine receptor 4 (CXCR4)] form a signaling pathway that plays critical roles in different pathological and phys...
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| Veröffentlicht in: | Molecular biology reports 2022-04, Vol.49 (4), p.3307-3320 |
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| creator | Sadri, Farzad Rezaei, Zohreh Fereidouni, Mohammad |
| description | Chemokines are chemoattractants that can regulate cell movement and adhesion. SDF-1 [stromal cell-derived factor-1 (SDF-1)] is a homeostatic CXC chemokine. SDF-1 and its receptors [CXC chemokine receptor 4 (CXCR4)] form a signaling pathway that plays critical roles in different pathological and physiological mechanisms, including embryogenesis, wound healing, angiogenesis, tumor growth, and proliferation. Therefore, the current review aimed to summarize the related studies that addressed the molecular signature of the SDF-1/CXCR4 pathway and to explain how this axis is involved in normal events. |
| doi_str_mv | 10.1007/s11033-021-07069-3 |
| format | Article |
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SDF-1 [stromal cell-derived factor-1 (SDF-1)] is a homeostatic CXC chemokine. SDF-1 and its receptors [CXC chemokine receptor 4 (CXCR4)] form a signaling pathway that plays critical roles in different pathological and physiological mechanisms, including embryogenesis, wound healing, angiogenesis, tumor growth, and proliferation. 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SDF-1 [stromal cell-derived factor-1 (SDF-1)] is a homeostatic CXC chemokine. SDF-1 and its receptors [CXC chemokine receptor 4 (CXCR4)] form a signaling pathway that plays critical roles in different pathological and physiological mechanisms, including embryogenesis, wound healing, angiogenesis, tumor growth, and proliferation. 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| subjects | Angiogenesis Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Cell Movement - physiology Chemokine CXCL12 Chemokine receptors Chemokines Chemotactic factors CXC chemokines CXCR4 protein Embryogenesis Histology Humans Life Sciences Morphology Neoplasms - metabolism Neovascularization, Pathologic Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism Review SDF-1 protein Signal Transduction Tumors Wound healing |
| title | The significance of the SDF-1/CXCR4 signaling pathway in the normal development |
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