The Pellino1-PKCθ Signaling Axis Is an Essential Target for Improving Antitumor CD8+ T-lymphocyte Function

CD8+ T cells play an important role in the elimination of tumors. However, the underlying mechanisms involved in eliciting and maintaining effector responses in CD8+ T cells remain to be elucidated. Pellino1 (Peli1) is a receptor signal-responsive ubiquitin E3 ligase, which acts as a critical mediat...

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Veröffentlicht in:	Cancer immunology research 2022-03, Vol.10 (3), p.327-342
Hauptverfasser:	Park, Jihyun, Lee, Si-Yeon, Jeon, Yoon, Kim, Kyung-Mo, Lee, Jin-Kwan, Ko, Jiwon, Park, Eun-Ji, Yoon, Joon-Sup, Kang, Baeki E, Ryu, Dongryeol, Lee, Ho, Shin, Su-Jin, Go, Heounjeong, Lee, Chang-Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	CD8-Positive T-Lymphocytes - metabolism Lymphocytes, Tumor-Infiltrating - metabolism Nuclear Proteins Protein Kinase C-theta - metabolism Signal Transduction Ubiquitin-Protein Ligases - metabolism
Online-Zugang:	Volltext
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