CD30-targeted therapy induces apoptosis of inflammatory cytokine-stimulated synovial fibroblasts and ameliorates collagen antibody-induced arthritis in mice

Objective It has been reported that levels of soluble CD30 in serum and joint fluid are significantly elevated in patients with rheumatoid arthritis (RA). This study aimed to investigate whether CD30 could be a therapeutic target for RA. Methods The expression and localization of CD30 were examined...

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Veröffentlicht in:	Inflammation research 2022-02, Vol.71 (2), p.215-226
Hauptverfasser:	Matsuhashi, Minami, Nishida, Keiichiro, Sakamoto, Misa, Gion, Yuka, Yoshida, Aki, Katsuyama, Takayuki, Nakahara, Ryuichi, Nasu, Yoshihisa, Matsumoto, Yoshinori, Sato, Yasuharu, Ozaki, Toshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Allergology Antibodies Apoptosis Apoptosis - drug effects Arthritis Arthritis, Experimental - drug therapy Arthritis, Experimental - immunology Arthritis, Experimental - pathology Biomedical and Life Sciences Biomedical materials Biomedicine Brentuximab Vedotin - pharmacology Brentuximab Vedotin - therapeutic use CD20 antigen CD30 antigen Collagen Cytokines Cytokines - pharmacology Dermatology Female Fibroblasts Fibroblasts - drug effects Fibroblasts - pathology Flow cytometry Gene expression Humans IL-1β Immunofluorescence Immunology Immunotherapy Inflammation Interleukin 6 Joints (anatomy) Ki-1 Antigen - analysis Ki-1 Antigen - antagonists & inhibitors Ki-1 Antigen - genetics Localization Male Middle Aged Monoclonal antibodies Neurology Original Research Article Osteoarthritis Patients Pharmacology/Toxicology Polymerase chain reaction Rheumatoid arthritis Rheumatology Serum levels Stimulation Synoviocytes Synoviocytes - drug effects Synoviocytes - pathology Therapeutic targets Tumor necrosis factor-α
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