NUT carcinoma of the parotid gland: report of two cases, one with a rare ZNF532-NUTM1 fusion

Nuclear protein in testis (NUT) carcinoma (NC) is a rare aggressive tumor with a typical NUTM1 gene rearrangement. Herein, we aimed to investigate the morphological and genetic features of head and neck NC. Immunohistochemistry staining for NUT (C52B1) was performed for 118 samples of head and neck...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2022-04, Vol.480 (4), p.887-897
Hauptverfasser:	Chen, Min, Zhao, Sha, Liang, Zuoyu, Wang, Weiya, Zhou, Ping, Jiang, Lili
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Carcinoma - genetics CD34 antigen CD99 antigen Cell Cycle Proteins - genetics Exocrine glands Fatalities Female Fluorescence in situ hybridization Fusion protein Gene rearrangement Genotypes Head and neck carcinoma Humans Hybridization Immunohistochemistry In Situ Hybridization, Fluorescence Keratinization Male Medicine Medicine & Public Health Middle Aged Morphology Mutation Myc protein Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Next-generation sequencing Nuclear fusion Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncogene Proteins, Fusion - genetics Oral cancer Original Article Parotid gland Parotid Gland - metabolism Pathology PD-L1 protein Salivary glands Squamous cells Staining Synaptophysin Transcription Factors - genetics Transcription Factors - metabolism Trisomy Tumors Young Adult
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