Development of naringenin-O-carbamate derivatives as multi-target-directed liagnds for the treatment of Alzheimer’s disease

[Display omitted] •3c was a good and balanced multifunctional agent.•3c was a good antioxidant agent and selective metal ions chelator.•3c presented good neuroprotective effect and hepatoprotective effect.•3c demonstrated favourable BBB penetration in vitro and drug-like property. In this work, a se...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2022-03, Vol.60, p.128574-128574, Article 128574
Hauptverfasser:	Mi, Jing, He, Ying, Yang, Jing, Zhou, Yi, Zhu, Gaofeng, Wu, Anguo, Liu, Wenmin, Sang, Zhipei
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease Blood-brain barrier penetration Multi-function agents Naringenin-O-carbamate derivatives
Online-Zugang:	Volltext
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