Development of a fast, online three-phase electroextraction hyphenated to fast liquid chromatography–mass spectrometry for analysis of trace-level acid pharmaceuticals in plasma

Sample preparation is a challenge for high-throughput analysis, especially for volume-limited samples with low-abundant analytes. Ideally, sample preparation enriches the analytes of interest while removing the interferents to reduce the matrix effect and improve both sensitivity and quantification....

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Veröffentlicht in:	Analytica chimica acta 2022-02, Vol.1192, p.339364-339364, Article 339364
Hauptverfasser:	He, Yupeng, Drouin, Nicolas, Wouters, Bert, Miggiels, Paul, Hankemeier, Thomas, Lindenburg, Peter W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Bioanalysis Chromatography, Liquid Electroextraction Human plasma Mass Spectrometry Online fast LC-MS Pharmaceutical Preparations Proteins Sample preparation
Online-Zugang:	Volltext
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