Photonic Hydrogels for Synergistic Visual Bacterial Detection and On-Site Photothermal Disinfection
Rapid and sensitive diagnostics in the early stage of bacterial infection and immediate treatment play critical roles in the control of infectious diseases. However, it remains challenging to develop integrated systems with both rapid detection of bacterial infection and timely on-demand disinfectio...
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| Veröffentlicht in: | ACS applied materials & interfaces 2022-02, Vol.14 (4), p.5856-5866 |
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| container_title | ACS applied materials & interfaces |
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| creator | Xie, Ge Du, Shuo Huang, Qiuyi Mo, Min Gao, Yujie Li, Miaomiao Tao, Juan Zhang, Lianbin Zhu, Jintao |
| description | Rapid and sensitive diagnostics in the early stage of bacterial infection and immediate treatment play critical roles in the control of infectious diseases. However, it remains challenging to develop integrated systems with both rapid detection of bacterial infection and timely on-demand disinfection ability. Herein, we demonstrate a photonic hydrogel platform integrating visual diagnosis and on-site photothermal disinfection by incorporating Fe3O4@C nanoparticles into a poly(hydroxyethyl methacrylate)-co-polyacrylamide (PHEMA-co-PAAm) matrix. In vitro experiments demonstrate that such a hydrogel can respond to pH variation caused by bacterial metabolism and generate the corresponding color changes to realize naked-eye observation. Meanwhile, its excellent photothermal conversion ability enables it to effectively kill bacteria by destroying cell membranes under near-infrared irradiation. Moreover, the pigskin infection wound model also verifies the bacterial detection performance and disinfection ability of the hydrogel in vivo. Our strategy demonstrates a new approach for visual diagnosis and treatment of bacterial infections. |
| doi_str_mv | 10.1021/acsami.1c22586 |
| format | Article |
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However, it remains challenging to develop integrated systems with both rapid detection of bacterial infection and timely on-demand disinfection ability. Herein, we demonstrate a photonic hydrogel platform integrating visual diagnosis and on-site photothermal disinfection by incorporating Fe3O4@C nanoparticles into a poly(hydroxyethyl methacrylate)-co-polyacrylamide (PHEMA-co-PAAm) matrix. In vitro experiments demonstrate that such a hydrogel can respond to pH variation caused by bacterial metabolism and generate the corresponding color changes to realize naked-eye observation. Meanwhile, its excellent photothermal conversion ability enables it to effectively kill bacteria by destroying cell membranes under near-infrared irradiation. Moreover, the pigskin infection wound model also verifies the bacterial detection performance and disinfection ability of the hydrogel in vivo. 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Mater. Interfaces</addtitle><description>Rapid and sensitive diagnostics in the early stage of bacterial infection and immediate treatment play critical roles in the control of infectious diseases. However, it remains challenging to develop integrated systems with both rapid detection of bacterial infection and timely on-demand disinfection ability. Herein, we demonstrate a photonic hydrogel platform integrating visual diagnosis and on-site photothermal disinfection by incorporating Fe3O4@C nanoparticles into a poly(hydroxyethyl methacrylate)-co-polyacrylamide (PHEMA-co-PAAm) matrix. In vitro experiments demonstrate that such a hydrogel can respond to pH variation caused by bacterial metabolism and generate the corresponding color changes to realize naked-eye observation. Meanwhile, its excellent photothermal conversion ability enables it to effectively kill bacteria by destroying cell membranes under near-infrared irradiation. Moreover, the pigskin infection wound model also verifies the bacterial detection performance and disinfection ability of the hydrogel in vivo. 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| subjects | Acrylic Resins - chemistry Animals Disinfectants - chemistry Disinfectants - radiation effects Disinfectants - therapeutic use Escherichia coli - drug effects Functional Nanostructured Materials (including low-D carbon) Hydrogels - chemistry Infrared Rays Magnetite Nanoparticles - chemistry Magnetite Nanoparticles - radiation effects Magnetite Nanoparticles - therapeutic use Mice NIH 3T3 Cells Photothermal Therapy Polyhydroxyethyl Methacrylate - chemistry Staphylococcal Skin Infections - diagnostic imaging Staphylococcal Skin Infections - drug therapy Staphylococcus aureus - drug effects Swine |
| title | Photonic Hydrogels for Synergistic Visual Bacterial Detection and On-Site Photothermal Disinfection |
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