Hydrogel-based patient-friendly photodynamic therapy of oral potentially malignant disorders
Oral potentially malignant disorders (OPMDs) are precursor lesions with an increased risk of malignant transformation. Topical photodynamic therapy (PDT) mediated by 5-aminolevulinic acid (ALA) (ALA-PDT) is a promising therapeutic method in the treatment of OPMDs. However, the clinical application o...
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| Veröffentlicht in: | Biomaterials 2022-02, Vol.281, p.121377-121377, Article 121377 |
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| creator | Wang, Xing Yuan, Zuoying Tao, Anqi Wang, Pudi Xie, Wenyue Yang, Shuo Huang, Jianyong Wen, Ning |
| description | Oral potentially malignant disorders (OPMDs) are precursor lesions with an increased risk of malignant transformation. Topical photodynamic therapy (PDT) mediated by 5-aminolevulinic acid (ALA) (ALA-PDT) is a promising therapeutic method in the treatment of OPMDs. However, the clinical application of topical ALA-PDT is restricted by several limitations, including low delivery efficiency, poor comfort, and easy influence by saliva. Here, we designed a highly adhesion-strength dry polyacrylic acid (PAA)-chitosan (CHI)-ALA interpenetrating network hydrogel (PACA) patch after investigating the spatiotemporal dynamics of ALA drug delivery via diffusion-based finite-element models. The PACA patch could adhere to the moist oral mucosa fast and stably and deliver ALA. PACA hydrogel-mediated PDT (PACA-PDT) effectively improved OPMDs in vitro and in a hamster oral carcinogenesis model. In particular, we conducted a trial to recruit 60 OPMD volunteers to demonstrate the feasibility and comfort of the PACA hydrogel patch. This study provides evidence that PACA hydrogel-mediated PDT could be a patient-friendly treatment modality for OPMDs.
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| doi_str_mv | 10.1016/j.biomaterials.2022.121377 |
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[Display omitted]</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2022.121377</identifier><identifier>PMID: 35065330</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Aminolevulinic Acid - therapeutic use ; Animals ; Cricetinae ; Dry hydrogel patch ; Humans ; Hydrogels - therapeutic use ; Oral leukoplakia ; Oral potentially malignant disorders ; Patient-friendly treatment ; Photochemotherapy - methods ; Photodynamic therapy ; Photosensitizing Agents - therapeutic use ; Precancerous Conditions - drug therapy</subject><ispartof>Biomaterials, 2022-02, Vol.281, p.121377-121377, Article 121377</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-5d4c8fb57fe61a072bfe9097251595b9132c992496c07bc6c0b634a89edce36b3</citedby><cites>FETCH-LOGICAL-c380t-5d4c8fb57fe61a072bfe9097251595b9132c992496c07bc6c0b634a89edce36b3</cites><orcidid>0000-0002-6581-895X ; 0000-0001-9059-2406</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2022.121377$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35065330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xing</creatorcontrib><creatorcontrib>Yuan, Zuoying</creatorcontrib><creatorcontrib>Tao, Anqi</creatorcontrib><creatorcontrib>Wang, Pudi</creatorcontrib><creatorcontrib>Xie, Wenyue</creatorcontrib><creatorcontrib>Yang, Shuo</creatorcontrib><creatorcontrib>Huang, Jianyong</creatorcontrib><creatorcontrib>Wen, Ning</creatorcontrib><title>Hydrogel-based patient-friendly photodynamic therapy of oral potentially malignant disorders</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Oral potentially malignant disorders (OPMDs) are precursor lesions with an increased risk of malignant transformation. Topical photodynamic therapy (PDT) mediated by 5-aminolevulinic acid (ALA) (ALA-PDT) is a promising therapeutic method in the treatment of OPMDs. However, the clinical application of topical ALA-PDT is restricted by several limitations, including low delivery efficiency, poor comfort, and easy influence by saliva. Here, we designed a highly adhesion-strength dry polyacrylic acid (PAA)-chitosan (CHI)-ALA interpenetrating network hydrogel (PACA) patch after investigating the spatiotemporal dynamics of ALA drug delivery via diffusion-based finite-element models. The PACA patch could adhere to the moist oral mucosa fast and stably and deliver ALA. PACA hydrogel-mediated PDT (PACA-PDT) effectively improved OPMDs in vitro and in a hamster oral carcinogenesis model. In particular, we conducted a trial to recruit 60 OPMD volunteers to demonstrate the feasibility and comfort of the PACA hydrogel patch. This study provides evidence that PACA hydrogel-mediated PDT could be a patient-friendly treatment modality for OPMDs.
[Display omitted]</description><subject>Aminolevulinic Acid - therapeutic use</subject><subject>Animals</subject><subject>Cricetinae</subject><subject>Dry hydrogel patch</subject><subject>Humans</subject><subject>Hydrogels - therapeutic use</subject><subject>Oral leukoplakia</subject><subject>Oral potentially malignant disorders</subject><subject>Patient-friendly treatment</subject><subject>Photochemotherapy - methods</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Precancerous Conditions - drug therapy</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkElLxDAUgIMoOi5_QYonLx2zNG3jTdxB8KI3IWR51QxtU5OM0H9vZFQ8enmPB9_bPoROCF4STOqz1VI7P6gEwak-LimmdEkoYU2zhRakbdqSC8y30QKTipaiJnQP7ce4wrnGFd1Fe4zjmjOGF-jlbrbBv0JfahXBFpNKDsZUdiEn28_F9OaTt_OoBmeK9AZBTXPhu8IH1ReTTxnOV2RwUL17HdWYCuuiDxZCPEQ7Xb4Qjr7zAXq-uX66vCsfHm_vLy8eSsNanEpuK9N2mjcd1EThhuoOBBYN5YQLrgVh1AhBK1Eb3GiTo65ZpVoB1gCrNTtAp5u5U_Dva4hJDi4a6Hs1gl9HSWtKaYs5ERk936Am-BgDdHIKblBhlgTLL7tyJf_alV925cZubj7-3rPWA9jf1h-dGbjaAJC__XAQZDTZowHrApgkrXf_2fMJDlGUCA</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Wang, Xing</creator><creator>Yuan, Zuoying</creator><creator>Tao, Anqi</creator><creator>Wang, Pudi</creator><creator>Xie, Wenyue</creator><creator>Yang, Shuo</creator><creator>Huang, Jianyong</creator><creator>Wen, Ning</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6581-895X</orcidid><orcidid>https://orcid.org/0000-0001-9059-2406</orcidid></search><sort><creationdate>202202</creationdate><title>Hydrogel-based patient-friendly photodynamic therapy of oral potentially malignant disorders</title><author>Wang, Xing ; Yuan, Zuoying ; Tao, Anqi ; Wang, Pudi ; Xie, Wenyue ; Yang, Shuo ; Huang, Jianyong ; Wen, Ning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-5d4c8fb57fe61a072bfe9097251595b9132c992496c07bc6c0b634a89edce36b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aminolevulinic Acid - therapeutic use</topic><topic>Animals</topic><topic>Cricetinae</topic><topic>Dry hydrogel patch</topic><topic>Humans</topic><topic>Hydrogels - therapeutic use</topic><topic>Oral leukoplakia</topic><topic>Oral potentially malignant disorders</topic><topic>Patient-friendly treatment</topic><topic>Photochemotherapy - methods</topic><topic>Photodynamic therapy</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Precancerous Conditions - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xing</creatorcontrib><creatorcontrib>Yuan, Zuoying</creatorcontrib><creatorcontrib>Tao, Anqi</creatorcontrib><creatorcontrib>Wang, Pudi</creatorcontrib><creatorcontrib>Xie, Wenyue</creatorcontrib><creatorcontrib>Yang, Shuo</creatorcontrib><creatorcontrib>Huang, Jianyong</creatorcontrib><creatorcontrib>Wen, Ning</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xing</au><au>Yuan, Zuoying</au><au>Tao, Anqi</au><au>Wang, Pudi</au><au>Xie, Wenyue</au><au>Yang, Shuo</au><au>Huang, Jianyong</au><au>Wen, Ning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydrogel-based patient-friendly photodynamic therapy of oral potentially malignant disorders</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2022-02</date><risdate>2022</risdate><volume>281</volume><spage>121377</spage><epage>121377</epage><pages>121377-121377</pages><artnum>121377</artnum><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Oral potentially malignant disorders (OPMDs) are precursor lesions with an increased risk of malignant transformation. Topical photodynamic therapy (PDT) mediated by 5-aminolevulinic acid (ALA) (ALA-PDT) is a promising therapeutic method in the treatment of OPMDs. However, the clinical application of topical ALA-PDT is restricted by several limitations, including low delivery efficiency, poor comfort, and easy influence by saliva. Here, we designed a highly adhesion-strength dry polyacrylic acid (PAA)-chitosan (CHI)-ALA interpenetrating network hydrogel (PACA) patch after investigating the spatiotemporal dynamics of ALA drug delivery via diffusion-based finite-element models. The PACA patch could adhere to the moist oral mucosa fast and stably and deliver ALA. PACA hydrogel-mediated PDT (PACA-PDT) effectively improved OPMDs in vitro and in a hamster oral carcinogenesis model. In particular, we conducted a trial to recruit 60 OPMD volunteers to demonstrate the feasibility and comfort of the PACA hydrogel patch. This study provides evidence that PACA hydrogel-mediated PDT could be a patient-friendly treatment modality for OPMDs.
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aminolevulinic Acid - therapeutic use Animals Cricetinae Dry hydrogel patch Humans Hydrogels - therapeutic use Oral leukoplakia Oral potentially malignant disorders Patient-friendly treatment Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - therapeutic use Precancerous Conditions - drug therapy |
| title | Hydrogel-based patient-friendly photodynamic therapy of oral potentially malignant disorders |
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