Optical genome mapping reveals additional prognostic information compared to conventional cytogenetics in AML/MDS patients

Cytogenetic diagnostics play a crucial role in risk stratification and classification of myeloid malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), thus influencing treatment decisions. Optical genome mapping (OGM) is a novel whole genome method for the detection o...

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Veröffentlicht in:	International journal of cancer 2022-06, Vol.150 (12), p.1998-2011
Hauptverfasser:	Gerding, Wanda M., Tembrink, Marco, Nilius‐Eliliwi, Verena, Mika, Thomas, Dimopoulos, Fotios, Ladigan‐Badura, Swetlana, Eckhardt, Matthias, Pohl, Michael, Wünnenberg, Max, Farshi, Pakhshan, Reimer, Peter, Schroers, Roland, Nguyen, Huu Phuc, Vangala, Deepak B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Cancer Chromosome Mapping - methods Cytogenetic Analysis - methods Cytogenetics Fluorescence in situ hybridization Gene mapping Genomes human genetic diagnostics Humans In Situ Hybridization, Fluorescence - methods Karyotypes Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - genetics Medical research Myelodysplastic syndrome Myelodysplastic syndromes Myelodysplastic Syndromes - diagnosis Myelodysplastic Syndromes - genetics optical genome mapping Patients Prognosis Tumors
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