The incidence and clinical features of familial pancreatic cancer in Korea

Background A history of familial pancreatic cancer (FPC) increases the incidence of pancreatic cancer (PC) among first‐degree relatives. We aimed to determine the incidence of FPC and analyze its clinical characteristics. Methods Between 2010 and 2014, 1159 patients with PC were included in the study. We evaluated the incidence of FPC, clinicopathological features, and survival prognosis between FPC and non‐FPC patients. We further analyzed the clinical outcomes of 389 patients with PC who underwent curative‐intent surgery. Results Familial pancreatic cancer incidence was 3.1% (n = 36) among all patients with PC (n = 1159). FPC was diagnosed at an advanced clinical stage compared to non‐FPC (P = .041). The tested variables and 5‐year survival rate (5YSR) between FPC and non‐FPC after propensity score matching had no differences (5YSR: 4.6% vs 2.6%, P = .834). Among PC patients who underwent curative‐intent surgery (n = 389), FPC incidence was 1.8% (n = 7). FPC patients were older than non‐FPC patients (75.3 ± 4.7 years vs 64.0 ± 9.9 years, P