KCNQ channel PIP2 modulation: Two loose links, three rings, and a twist

In this issue of Neuron, structures by Zheng et al. (2022) provide a newly comprehensive view of KCNQ channel interaction with phosphatidyl inositol 4,5-bisphosphate (PIP2), yielding insights for modulatory mechanisms of channels implicated in deafness, epilepsy, autism, and intellectual disability....

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2022-01, Vol.110 (2), p.178-180
Hauptverfasser:	Cooper, Edward C., Abreo, Timothy, Tran, Baouyen
Format:	Artikel
Sprache:	eng
Schlagworte:	Epilepsy - genetics Humans Ion Channel Gating - physiology Neurons Phosphatidylinositol 4,5-Diphosphate
Online-Zugang:	Volltext
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Zusammenfassung:	In this issue of Neuron, structures by Zheng et al. (2022) provide a newly comprehensive view of KCNQ channel interaction with phosphatidyl inositol 4,5-bisphosphate (PIP2), yielding insights for modulatory mechanisms of channels implicated in deafness, epilepsy, autism, and intellectual disability. In this issue of Neuron, structures by Zheng et al. (2022) provide a newly comprehensive view of KCNQ channel interaction with phosphatidyl inositol 4,5-bisphosphate (PIP2), yielding insights for modulatory mechanisms of channels implicated in deafness, epilepsy, autism, and intellectual disability.
ISSN:	0896-6273 1097-4199
DOI:	10.1016/j.neuron.2021.12.026