Immunostimulation of tumor microenvironment by targeting tumor-associated macrophages with hypoxia-responsive nanocomplex for enhanced anti-tumor therapy

Tumor-associated macrophages (TAMs), which dampen the therapeutic efficacy of cancer immunotherapy, are the key players in the immunosuppressive tumor microenvironment (TME). Therefore, reprogramming TAMs into tumoricidal M1 macrophages possesses considerable potential as a novel immunotherapy. Howe...

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Veröffentlicht in:	Journal of controlled release 2022-03, Vol.343, p.78-88
Hauptverfasser:	Kang, Yeoul, Lim, Junha, Saravanakumar, Gurusamy, Kim, Jinseong, Park, Mihyeon, Im, Sooseok, Kim, Won Jong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer immunotherapy CD8-Positive T-Lymphocytes Hypoxia Hypoxia - therapy Immunization Mice Neoplasms - therapy Poly(I:C) Polyethylene Glycols - chemistry Tumor Microenvironment Tumor-Associated Macrophages
Online-Zugang:	Volltext
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