Protective role of coffee supplementation in liver cirrhosis: Study in rats
Present study was designed to evaluate the effects of coffee on liver function tests and liver antioxidant enzymes in thioacetamide induced liver cirrhosis in rats. Experimental study period was consisted of eighteen weeks divided into two phases. Therefore 24 rats were distributed randomly into fou...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2021-03, Vol.34 (2), p.591-597 |
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| creator | Fatima Zaidi, Syeda Nuzhat Madni, Muhammad |
| description | Present study was designed to evaluate the effects of coffee on liver function tests and liver antioxidant enzymes in thioacetamide induced liver cirrhosis in rats. Experimental study period was consisted of eighteen weeks divided into two phases. Therefore 24 rats were distributed randomly into four groups (n=6). Group I served as control. In phase I, group II and III received thioacetamide (200mg/kg body weight intraperitoneally twice a week) and group IV received saline for 12 weeks. In phase II, group II received saline while group III and IV received an oral dose of coffee (0.4mg/Kg b.w) daily for 6 weeks. At the end of the study period rats were sacrificed and blood was collected to get serum and liver was homogenized for the determination of antioxidant enzymes. Marked increase in serum total and direct bilirubin, ALT, AST whereas reduced ALP was observed in test group. The reduced tissue SOD activity and increased tissue catalase and tissue MDA activity were also observed in test group. However, coffee consumption in group III in phase II significantly restored liver biomarkers and the tissue antioxidant enzymes SOD, catalase and MDA activities. In conclusion, thioacetamide induced liver cirrhosis can be prevented by coffee supplementation. |
| doi_str_mv | 10.36721/PJPS.2021.34.2.REG.591-597.1 |
| format | Article |
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Experimental study period was consisted of eighteen weeks divided into two phases. Therefore 24 rats were distributed randomly into four groups (n=6). Group I served as control. In phase I, group II and III received thioacetamide (200mg/kg body weight intraperitoneally twice a week) and group IV received saline for 12 weeks. In phase II, group II received saline while group III and IV received an oral dose of coffee (0.4mg/Kg b.w) daily for 6 weeks. At the end of the study period rats were sacrificed and blood was collected to get serum and liver was homogenized for the determination of antioxidant enzymes. Marked increase in serum total and direct bilirubin, ALT, AST whereas reduced ALP was observed in test group. The reduced tissue SOD activity and increased tissue catalase and tissue MDA activity were also observed in test group. However, coffee consumption in group III in phase II significantly restored liver biomarkers and the tissue antioxidant enzymes SOD, catalase and MDA activities. In conclusion, thioacetamide induced liver cirrhosis can be prevented by coffee supplementation.</description><identifier>ISSN: 1011-601X</identifier><identifier>DOI: 10.36721/PJPS.2021.34.2.REG.591-597.1</identifier><identifier>PMID: 34275834</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Alanine Transaminase - metabolism ; Alkaline Phosphatase - metabolism ; Animals ; Antioxidants ; Aspartate Aminotransferases - metabolism ; Bilirubin ; Bilirubin - metabolism ; Body weight ; Catalase - metabolism ; Coffee ; Dietary Supplements ; Enzymes ; Ethylenediaminetetraacetic acid ; Lipid Peroxidation ; Liver cirrhosis ; Liver Cirrhosis - chemically induced ; Liver Cirrhosis - metabolism ; Liver Cirrhosis, Experimental - chemically induced ; Liver Cirrhosis, Experimental - metabolism ; Malondialdehyde - metabolism ; Rats ; Superoxide Dismutase - metabolism ; Thioacetamide - toxicity</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2021-03, Vol.34 (2), p.591-597</ispartof><rights>COPYRIGHT 2021 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34275834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fatima Zaidi, Syeda Nuzhat</creatorcontrib><creatorcontrib>Madni, Muhammad</creatorcontrib><title>Protective role of coffee supplementation in liver cirrhosis: Study in rats</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>Present study was designed to evaluate the effects of coffee on liver function tests and liver antioxidant enzymes in thioacetamide induced liver cirrhosis in rats. Experimental study period was consisted of eighteen weeks divided into two phases. Therefore 24 rats were distributed randomly into four groups (n=6). Group I served as control. In phase I, group II and III received thioacetamide (200mg/kg body weight intraperitoneally twice a week) and group IV received saline for 12 weeks. In phase II, group II received saline while group III and IV received an oral dose of coffee (0.4mg/Kg b.w) daily for 6 weeks. At the end of the study period rats were sacrificed and blood was collected to get serum and liver was homogenized for the determination of antioxidant enzymes. Marked increase in serum total and direct bilirubin, ALT, AST whereas reduced ALP was observed in test group. The reduced tissue SOD activity and increased tissue catalase and tissue MDA activity were also observed in test group. However, coffee consumption in group III in phase II significantly restored liver biomarkers and the tissue antioxidant enzymes SOD, catalase and MDA activities. In conclusion, thioacetamide induced liver cirrhosis can be prevented by coffee supplementation.</description><subject>Alanine Transaminase - metabolism</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Aspartate Aminotransferases - metabolism</subject><subject>Bilirubin</subject><subject>Bilirubin - metabolism</subject><subject>Body weight</subject><subject>Catalase - metabolism</subject><subject>Coffee</subject><subject>Dietary Supplements</subject><subject>Enzymes</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Lipid Peroxidation</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - chemically induced</subject><subject>Liver Cirrhosis - metabolism</subject><subject>Liver Cirrhosis, Experimental - chemically induced</subject><subject>Liver Cirrhosis, Experimental - metabolism</subject><subject>Malondialdehyde - metabolism</subject><subject>Rats</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Thioacetamide - toxicity</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0EtLxDAQAOAcFB-rf0EKInhpzbNtvIms62PBxVXwVtJ0opG2qUkq-O_toh4EmcPAzDfDMAidEJyxvKDkbHW7WmcUU5IxntHsYb7IhCSpkEVGttAewYSkOSbPu2g_hDeMcy6l3EG7jNNClIzvobuVdxF0tB-QeNdC4kyinTEASRiHoYUO-qiidX1i-6SdmE-09f7VBRvOk3Ucm89Nx6sYDtC2UW2Aw588Q09X88fL63R5v7i5vFimL7QoYypBaa6aulQl4dxALhgpGIAQwJWEptaMi1prZRolmdBlYyhmWBOoa4VLzWbo9Hvv4N37CCFWnQ0a2lb14MZQ0ZxSWnDBxUSPv-mLaqGyvXHRK73h1UWek5LKgpNJZf-oKRrorHY9GDvV_wwc_Vww1h001eBtp_xn9ftX9gUJCHt6</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Fatima Zaidi, Syeda Nuzhat</creator><creator>Madni, Muhammad</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>202103</creationdate><title>Protective role of coffee supplementation in liver cirrhosis: Study in rats</title><author>Fatima Zaidi, Syeda Nuzhat ; Madni, Muhammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g278t-9eac4adb8a8144fe653173ee55e4a9edbc345bccafda935c8df2030c1ebba08c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alanine Transaminase - metabolism</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Aspartate Aminotransferases - metabolism</topic><topic>Bilirubin</topic><topic>Bilirubin - metabolism</topic><topic>Body weight</topic><topic>Catalase - metabolism</topic><topic>Coffee</topic><topic>Dietary Supplements</topic><topic>Enzymes</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Lipid Peroxidation</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - chemically induced</topic><topic>Liver Cirrhosis - metabolism</topic><topic>Liver Cirrhosis, Experimental - chemically induced</topic><topic>Liver Cirrhosis, Experimental - metabolism</topic><topic>Malondialdehyde - metabolism</topic><topic>Rats</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Thioacetamide - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fatima Zaidi, Syeda Nuzhat</creatorcontrib><creatorcontrib>Madni, Muhammad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fatima Zaidi, Syeda Nuzhat</au><au>Madni, Muhammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective role of coffee supplementation in liver cirrhosis: Study in rats</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2021-03</date><risdate>2021</risdate><volume>34</volume><issue>2</issue><spage>591</spage><epage>597</epage><pages>591-597</pages><issn>1011-601X</issn><abstract>Present study was designed to evaluate the effects of coffee on liver function tests and liver antioxidant enzymes in thioacetamide induced liver cirrhosis in rats. Experimental study period was consisted of eighteen weeks divided into two phases. Therefore 24 rats were distributed randomly into four groups (n=6). Group I served as control. In phase I, group II and III received thioacetamide (200mg/kg body weight intraperitoneally twice a week) and group IV received saline for 12 weeks. In phase II, group II received saline while group III and IV received an oral dose of coffee (0.4mg/Kg b.w) daily for 6 weeks. At the end of the study period rats were sacrificed and blood was collected to get serum and liver was homogenized for the determination of antioxidant enzymes. Marked increase in serum total and direct bilirubin, ALT, AST whereas reduced ALP was observed in test group. The reduced tissue SOD activity and increased tissue catalase and tissue MDA activity were also observed in test group. However, coffee consumption in group III in phase II significantly restored liver biomarkers and the tissue antioxidant enzymes SOD, catalase and MDA activities. In conclusion, thioacetamide induced liver cirrhosis can be prevented by coffee supplementation.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>34275834</pmid><doi>10.36721/PJPS.2021.34.2.REG.591-597.1</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Alanine Transaminase - metabolism Alkaline Phosphatase - metabolism Animals Antioxidants Aspartate Aminotransferases - metabolism Bilirubin Bilirubin - metabolism Body weight Catalase - metabolism Coffee Dietary Supplements Enzymes Ethylenediaminetetraacetic acid Lipid Peroxidation Liver cirrhosis Liver Cirrhosis - chemically induced Liver Cirrhosis - metabolism Liver Cirrhosis, Experimental - chemically induced Liver Cirrhosis, Experimental - metabolism Malondialdehyde - metabolism Rats Superoxide Dismutase - metabolism Thioacetamide - toxicity |
| title | Protective role of coffee supplementation in liver cirrhosis: Study in rats |
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