A national longitudinal study evaluating the activity of cefditoren and other antibiotics against non-susceptible Streptococcus pneumoniae strains during the period 2004–20 in Spain
Abstract Background Surveillance studies including antibiotic resistance and evolution of pneumococcal serotypes are critical to evaluate the susceptibility of commonly used antibiotics and the contribution of conjugate vaccines against resistant strains. Objectives To determine the susceptibility o...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2022-03, Vol.77 (4), p.1045-1051 |
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| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 77 |
| creator | Sempere, Julio González-Camacho, Fernando Domenech, Mirian Llamosí, Mirella Del Río, Idoia López-Ruiz, Beatriz Gimeno, Mercedes Coronel, Pilar Yuste, Jose |
| description | Abstract
Background
Surveillance studies including antibiotic resistance and evolution of pneumococcal serotypes are critical to evaluate the susceptibility of commonly used antibiotics and the contribution of conjugate vaccines against resistant strains.
Objectives
To determine the susceptibility of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to penicillin to a panel of antibiotics during the period 2004–20 and characterize the impact of pneumococcal conjugate vaccines in the evolution of resistant serotypes.
Methods
We selected 3017 clinical isolates in order to determine the minimal inhibitory concentration to penicillin, amoxicillin, cefotaxime, erythromycin, levofloxacin and oral cephalosporins, including cefditoren, cefixime and cefpodoxime.
Results
The antibiotics with the lowest proportion of resistant strains from 2004 to 2020 were cefditoren ( |
| doi_str_mv | 10.1093/jac/dkab482 |
| format | Article |
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Background
Surveillance studies including antibiotic resistance and evolution of pneumococcal serotypes are critical to evaluate the susceptibility of commonly used antibiotics and the contribution of conjugate vaccines against resistant strains.
Objectives
To determine the susceptibility of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to penicillin to a panel of antibiotics during the period 2004–20 and characterize the impact of pneumococcal conjugate vaccines in the evolution of resistant serotypes.
Methods
We selected 3017 clinical isolates in order to determine the minimal inhibitory concentration to penicillin, amoxicillin, cefotaxime, erythromycin, levofloxacin and oral cephalosporins, including cefditoren, cefixime and cefpodoxime.
Results
The antibiotics with the lowest proportion of resistant strains from 2004 to 2020 were cefditoren (<0.4%), followed by cefotaxime (<5%), penicillin (<6.5%) and levofloxacin (<7%). Among oral cephalosporins, cefixime was the cephalosporin with the highest MIC90 (32 mg/L) and MIC50 (8–16 mg/L) throughout the study, followed by cefpodoxime with highest values of MIC90 (4 mg/L) and MIC50 (2 mg/L) for the majority of the study period. In contrast, cefditoren was the cephalosporin with the lowest MIC90 (1 mg/L) and MIC50 (0.25–0.5 mg/L).
Conclusions
Cefditoren was the antibiotic with the highest proportion of susceptible strains. Hence, more than 80% of the clinical strains were susceptible to cefditoren throughout the period 2004–20. The proportion of resistant isolates to cefditoren and cefotaxime was scarce, being less than 0.4% for cefditoren and lower than 5% for cefotaxime, despite the increased rates of serotypes not covered by the 13-valent pneumococcal conjugate vaccine.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkab482</identifier><identifier>PMID: 35045160</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Anti-Bacterial Agents - pharmacology ; Cephalosporins - pharmacology ; Humans ; Longitudinal Studies ; Microbial Sensitivity Tests ; Pneumococcal Infections - epidemiology ; Spain - epidemiology ; Streptococcus pneumoniae</subject><ispartof>Journal of antimicrobial chemotherapy, 2022-03, Vol.77 (4), p.1045-1051</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c250t-de0ac5237de015cc33c28dfee822beabdd618826068dedd4f19e516dfcd61a013</citedby><cites>FETCH-LOGICAL-c250t-de0ac5237de015cc33c28dfee822beabdd618826068dedd4f19e516dfcd61a013</cites><orcidid>0000-0001-7996-0837</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35045160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sempere, Julio</creatorcontrib><creatorcontrib>González-Camacho, Fernando</creatorcontrib><creatorcontrib>Domenech, Mirian</creatorcontrib><creatorcontrib>Llamosí, Mirella</creatorcontrib><creatorcontrib>Del Río, Idoia</creatorcontrib><creatorcontrib>López-Ruiz, Beatriz</creatorcontrib><creatorcontrib>Gimeno, Mercedes</creatorcontrib><creatorcontrib>Coronel, Pilar</creatorcontrib><creatorcontrib>Yuste, Jose</creatorcontrib><title>A national longitudinal study evaluating the activity of cefditoren and other antibiotics against non-susceptible Streptococcus pneumoniae strains during the period 2004–20 in Spain</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Abstract
Background
Surveillance studies including antibiotic resistance and evolution of pneumococcal serotypes are critical to evaluate the susceptibility of commonly used antibiotics and the contribution of conjugate vaccines against resistant strains.
Objectives
To determine the susceptibility of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to penicillin to a panel of antibiotics during the period 2004–20 and characterize the impact of pneumococcal conjugate vaccines in the evolution of resistant serotypes.
Methods
We selected 3017 clinical isolates in order to determine the minimal inhibitory concentration to penicillin, amoxicillin, cefotaxime, erythromycin, levofloxacin and oral cephalosporins, including cefditoren, cefixime and cefpodoxime.
Results
The antibiotics with the lowest proportion of resistant strains from 2004 to 2020 were cefditoren (<0.4%), followed by cefotaxime (<5%), penicillin (<6.5%) and levofloxacin (<7%). Among oral cephalosporins, cefixime was the cephalosporin with the highest MIC90 (32 mg/L) and MIC50 (8–16 mg/L) throughout the study, followed by cefpodoxime with highest values of MIC90 (4 mg/L) and MIC50 (2 mg/L) for the majority of the study period. In contrast, cefditoren was the cephalosporin with the lowest MIC90 (1 mg/L) and MIC50 (0.25–0.5 mg/L).
Conclusions
Cefditoren was the antibiotic with the highest proportion of susceptible strains. Hence, more than 80% of the clinical strains were susceptible to cefditoren throughout the period 2004–20. The proportion of resistant isolates to cefditoren and cefotaxime was scarce, being less than 0.4% for cefditoren and lower than 5% for cefotaxime, despite the increased rates of serotypes not covered by the 13-valent pneumococcal conjugate vaccine.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Cephalosporins - pharmacology</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Microbial Sensitivity Tests</subject><subject>Pneumococcal Infections - epidemiology</subject><subject>Spain - epidemiology</subject><subject>Streptococcus pneumoniae</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS1URIfCin11VxUSCr12Ek9mWVUFKlViUVhHjn0zuGTs1D-VZtd36MPwPjwJHs20S1Y-1vl8rnwPYx84fua4qs_vlD43v9XQdOIVW_BGYiVwxY_YAmtsq2XT1sfsbYx3iChb2b1hx3WLTcslLtifC3AqWe_UBJN3a5uysbtLLGIL9KCmXHy3hvSLQOlkH2zagh9B02hs8oEcKGfAFz8UlexgfbI6glor62IC510Vc9Q0F28iuE2hSK-91jnC7ChvvLOKysiwewEmh-eBMwXrDQjE5u_jk0CwDm7nQr1jr0c1RXp_OE_Yzy9XPy6_VTffv15fXtxUWrSYKkOodCvqZRG81bqutejMSNQJMZAajJG864RE2Rkyphn5ispizKiLoZDXJ-zjPncO_j5TTP3Glq9Mk3Lkc-yFFLwsVeKyoJ_2qA4-xkBjPwe7UWHbc-x3TfWlqf7QVKFPD8F52JB5YZ-rKcDZHvB5_m_SP4SAoxA</recordid><startdate>20220331</startdate><enddate>20220331</enddate><creator>Sempere, Julio</creator><creator>González-Camacho, Fernando</creator><creator>Domenech, Mirian</creator><creator>Llamosí, Mirella</creator><creator>Del Río, Idoia</creator><creator>López-Ruiz, Beatriz</creator><creator>Gimeno, Mercedes</creator><creator>Coronel, Pilar</creator><creator>Yuste, Jose</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7996-0837</orcidid></search><sort><creationdate>20220331</creationdate><title>A national longitudinal study evaluating the activity of cefditoren and other antibiotics against non-susceptible Streptococcus pneumoniae strains during the period 2004–20 in Spain</title><author>Sempere, Julio ; González-Camacho, Fernando ; Domenech, Mirian ; Llamosí, Mirella ; Del Río, Idoia ; López-Ruiz, Beatriz ; Gimeno, Mercedes ; Coronel, Pilar ; Yuste, Jose</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-de0ac5237de015cc33c28dfee822beabdd618826068dedd4f19e516dfcd61a013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Cephalosporins - pharmacology</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Microbial Sensitivity Tests</topic><topic>Pneumococcal Infections - epidemiology</topic><topic>Spain - epidemiology</topic><topic>Streptococcus pneumoniae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sempere, Julio</creatorcontrib><creatorcontrib>González-Camacho, Fernando</creatorcontrib><creatorcontrib>Domenech, Mirian</creatorcontrib><creatorcontrib>Llamosí, Mirella</creatorcontrib><creatorcontrib>Del Río, Idoia</creatorcontrib><creatorcontrib>López-Ruiz, Beatriz</creatorcontrib><creatorcontrib>Gimeno, Mercedes</creatorcontrib><creatorcontrib>Coronel, Pilar</creatorcontrib><creatorcontrib>Yuste, Jose</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sempere, Julio</au><au>González-Camacho, Fernando</au><au>Domenech, Mirian</au><au>Llamosí, Mirella</au><au>Del Río, Idoia</au><au>López-Ruiz, Beatriz</au><au>Gimeno, Mercedes</au><au>Coronel, Pilar</au><au>Yuste, Jose</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A national longitudinal study evaluating the activity of cefditoren and other antibiotics against non-susceptible Streptococcus pneumoniae strains during the period 2004–20 in Spain</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>2022-03-31</date><risdate>2022</risdate><volume>77</volume><issue>4</issue><spage>1045</spage><epage>1051</epage><pages>1045-1051</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><abstract>Abstract
Background
Surveillance studies including antibiotic resistance and evolution of pneumococcal serotypes are critical to evaluate the susceptibility of commonly used antibiotics and the contribution of conjugate vaccines against resistant strains.
Objectives
To determine the susceptibility of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to penicillin to a panel of antibiotics during the period 2004–20 and characterize the impact of pneumococcal conjugate vaccines in the evolution of resistant serotypes.
Methods
We selected 3017 clinical isolates in order to determine the minimal inhibitory concentration to penicillin, amoxicillin, cefotaxime, erythromycin, levofloxacin and oral cephalosporins, including cefditoren, cefixime and cefpodoxime.
Results
The antibiotics with the lowest proportion of resistant strains from 2004 to 2020 were cefditoren (<0.4%), followed by cefotaxime (<5%), penicillin (<6.5%) and levofloxacin (<7%). Among oral cephalosporins, cefixime was the cephalosporin with the highest MIC90 (32 mg/L) and MIC50 (8–16 mg/L) throughout the study, followed by cefpodoxime with highest values of MIC90 (4 mg/L) and MIC50 (2 mg/L) for the majority of the study period. In contrast, cefditoren was the cephalosporin with the lowest MIC90 (1 mg/L) and MIC50 (0.25–0.5 mg/L).
Conclusions
Cefditoren was the antibiotic with the highest proportion of susceptible strains. Hence, more than 80% of the clinical strains were susceptible to cefditoren throughout the period 2004–20. The proportion of resistant isolates to cefditoren and cefotaxime was scarce, being less than 0.4% for cefditoren and lower than 5% for cefotaxime, despite the increased rates of serotypes not covered by the 13-valent pneumococcal conjugate vaccine.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>35045160</pmid><doi>10.1093/jac/dkab482</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7996-0837</orcidid></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Anti-Bacterial Agents - pharmacology Cephalosporins - pharmacology Humans Longitudinal Studies Microbial Sensitivity Tests Pneumococcal Infections - epidemiology Spain - epidemiology Streptococcus pneumoniae |
| title | A national longitudinal study evaluating the activity of cefditoren and other antibiotics against non-susceptible Streptococcus pneumoniae strains during the period 2004–20 in Spain |
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